plasma homocysteine lowering intervention

systematic review meta-analysis network meta-analysis

Select cardiovascular prevention All type of patient       plasma homocysteine lowering intervention folic acid vs placebo or controlvs folic acid, vit B12 and vit B6      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	Non fatal MI (24)stroke (fatal and non fatal) (20)cardiovascular events (16)All cause death (15)Cancer (9)Cardiovascular death (6)cardiac death (5)Death from cancer (2) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	Non fatal MI	stroke (fatal and non fatal)
cardiovascular prevention
folic acid
FOLARDA (Liem), 2004	folic acid	control			Exploratory	negative
GOES (Liem), 2003	folic acid	control			Risk of bias	negative
NORVIT (folic acid + B12) (Bonaa), 2006    NCT	folic acid, B12	control			Low risk of bias	negative
NORVIT (folic acid, B12 and vit B6) (Bonaa), 2006    NCT	folic acid, vit B12 and vit B6	control			Low risk of bias	negative
CHAOS-2, 2002	folic acid	placebo			Low risk of bias	negative
CSPPT, 2015      NCT	folic acid	placebo			Low risk of bias	suggesting
SEARCH, 2007      NCT	folic acid, B12	placebo			Low risk of bias	negative
WENBIT (folic ac,B12), 2008    NCT	folic acid, B12	placebo			Low risk of bias	negative
WAFACS, 2008    NCT	folic acid, vit B12 and vit B6	placebo			Low risk of bias	negative
HOPE-2 (Lonn), 2006        NCT	folic acid, vit B12 and vit B6	placebo			Low risk of bias	suggesting
VITATOPS, 2010    NCT	folic acid, vit B12 and vit B6	placebo			Low risk of bias	suggesting
SU.FOL.OM3	folic acid, vit B12 and vit B6	placebo			Low risk of bias	negative
VISP (Toole), 2004	high dose - folic acid, vit B12 and vit B6	low dose - folic acid, vit B12 and vit B6			Low risk of bias	negative