inhibition of the renin-angiotensin system (ACEI or ARB)

systematic review meta-analysis network meta-analysis

Select heart failurepatients at high risk for cardiovascular events All type of patientpatients with preserved-LVEF heart failure       angiotensin receptor blockerangiotensin-converting enzyme inhibitors enalaprilperindoprilquinaprilramipriltrandolaprilirbesartantelmisartancandesartan vs placebo or controlvs placebo or no treatment      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (11)Cardiovascular death (11)cardiovascular events (9)Revascularization (9)stroke (fatal and non fatal) (8)Coronary event (7)Adverse events leading to treatment discontinuation (6)Cough (6)Hypotension (6)Non fatal MI (5)angiodema (5)cardiovascular death, MI, stroke (3)hospitalisation for heart failure (3)Cardiovascular death or hospital admission for CHF (2)Coronary death (1)Hospitalization for any reason (1)death or cardiovascular hospitalization (1)Death from any cause or hospitalization for any reason (1)Long term death (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	Cardiovascular death
heart failure
candesartan
CHARM preserved, 2003	candesartan	placebo			Low risk of bias	-
irbesartan
I-PRESERVE (McMurray), 2008      NCT	ibesartan	placebo			Low risk of bias	negative
perindopril
PEP CHF, 2006	perindopril	placebo			Low risk of bias	negative
patients at high risk for cardiovascular events
enalapril
CAMELOT (enalapril), 2004	enalapril	placebo			Low risk of bias	negative
perindopril
EUROPA, 2003	perindopril	placebo			Low risk of bias	suggesting
quinapril
QUIET, 2001	quinapril	placebo			Low risk of bias	negative
ramipril
HOPE, 2000	ramipril	placebo			Low risk of bias	suggesting
ONTARGET (association vs ramipril), 2008    NCT	telmisartan + ramipril	ramipril			Low risk of bias	negative
ONTARGET (association vs telmisartan), 2008    NCT	telmisartan + ramipril	telmisartan			Low risk of bias	suggesting
telmisartan
TRANSCEND, 2008    NCT	telmisartan	placebo			Low risk of bias	suggesting
ONTARGET (telmisartan alone), 2008      NCT	telmisartan	ramipril			Low risk of bias	suggesting
trandolapril
PEACE, 2004      NCT	trandolapril	placebo			Low risk of bias	suggesting