New P2Y12 Inhibitors

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathMajor bleeding

acute coronary syndrome  

cangrelor  
CHAMPION-PCI, 2009      NCTcangrelor up frontclopidogrel up frontLow risk of bias negative59%
CHAMPION-PLATFORM, 2009    NCTcangrelor up frontdelayed clopidogrelLow risk of bias negative
elinogrel  
ERASE-MI, 2009     elinogrelplaceboLow risk of bias negative
prasugrel  
JUMBO-TIMI 26, 2005   prasugrelclopidogrelLow risk of bias negative
TRITON-TIMI 38, 2007      NCTprasugrelclopidogrelLow risk of bias suggesting -5%31%
ticagrelor  
PLATO, 2009      NCTticagrelorclopidogrelLow risk of bias suggesting-22%3%
DISPERSE-2 (90mg), 2007       ticagrelorclopidogrelLow risk of bias negative37%-2%