thrombosis prevention

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultDeep vein thrombosis non-fatal pulmonary embolism

anticoagulant  

not classified  
Borsgtrom, 1965   no treatment -
acenocoumarol  
Hamulyak, 1994   AcenocoumarolNadroparinnegative18%
Samama, 2001     AcenocoumarolReviparinnegative 35%
van Geloven, 1977   Acenocoumarolunfractionated heparinLow risk of bias -
apixaban  
ADVANCE 3, 2010    NCTapixabanenoxaparinhip surgeryLow risk of bias suggesting-68%-60%
ADVANCE 2, 2010      NCTapixabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting-40%
APROPOS 2.5mg, 2007    NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
ADVANCE-1, 2008      NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting-5%
dabigatran  
RE-NOVATE (150mg), 2007      NCTdabigatran 150mgenoxaparinhip surgeryLow risk of bias negative -67%
RE-NOVATE (220mg), 2007      NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative70%
RE-NOVATE 2    NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative
RE-MODEL (150mg), 2007     dabigatran 150mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative∞%
RE-MODEL (220mg), 2007   dabigatran 220mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative
RE-MOBILIZE (150mg), 2008     dabigatran 150mgenoxaparin (US regimen)knee surgeryLow risk of bias negative -100%
RE-MOBILIZE (220mg), 2008     dabigatran 220mgenoxaparin (US regimen)knee surgeryLow risk of bias negative
edoxaban  
STARS J-V    NCTedoxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting
phenindione  
Eskeland, 1966   Phenindioneno treatment -
Hamilton, 1970     Phenindioneno treatment -
rivaroxaban  
RECORD 1, 2008      NCTrivaroxabanenoxaparinhip surgeryLow risk of bias suggesting-77%291%
RECORD 3, 2008    NCTrivaroxabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting-47%-100%
ODIXa-HIP 10mg, 2006   rivaroxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting-58%
RECORD 2, 2008    NCTrivaroxaban (long duration)enoxaparin (short duration)hip surgeryLow risk of bias suggesting-80%-75%
ODIXa-KNEE, 2005   rivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
RECORD 4, 2009    NCTrivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting-51%
warfarin  
Pinto, 1970   Warfarinno treatment -
Hume, 1973   Warfarinno treatment -
Morris, 1976     Warfarinno treatment -
Powers, 1989   Warfarinno treatment -
Myrhe, 1969   WarfarinplaceboLow risk of bias -
RD Heparin, 1994   WarfarinArdeparinsuggesting44%
Heit, 1997   WarfarinArdeparinLow risk of bias suggesting31%
Powers, 1989   WarfarinAspirin -
Lotke, 1997     WarfarinAspirin -
Francis, 1997     WarfarinDalteparinsuggesting77%
Hull, 2000     WarfarinDalteparinLow risk of bias suggesting 102%
Gerhart, 1991   WarfarinDanaparoid -
van Comp, 1998   WarfarinDanaparoid -
Myrhe, 1969   WarfarinDextranLow risk of bias -
Harris, 1972   WarfarinDextran -
Barber, 1977   WarfarinDextran -
Francis, 1983   WarfarinDextran -
Leclerc, 1996     WarfarinEnoxaparinLow risk of bias suggesting40%
Colwell, 1999     WarfarinEnoxaparinsuggesting407%
Fitzgerald, 2001     WarfarinEnoxaparinsuggesting 51%
Paiement, 1987   WarfarinIntermittent pneumatic compression -
Bailey, 1991   WarfarinIntermittent pneumatic compression -
Kaempffe, 1991     WarfarinIntermittent pneumatic compression -
Francis, 1992   WarfarinIntermittent pneumatic compression -
Hull, 1993     WarfarinLogiparinLow risk of bias suggesting19%
Hume, 1973   WarfarinSudoxicam -
Hume, 1973   Warfarinunfractionated heparin -
Barber, 1977   Warfarinunfractionated heparin -

antiplatelets drug  

not classified  
Veth, 1985   spcontrolRisk of bias -
Mocris-C , 1977   Flurbiprofenno treatmentExploratory negative8%
Massachusetts-I , 1981   Hydroxychloroquineno treatmentExploratory negative-100%
Denver-Il , 1980   dipyridamol + ASAplaceboLow risk of bias negative-86%-100%
Carter IA, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter IB, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter II, 1974   hydroxychloroquineplaceboLow risk of bias -
New York, 1977   hydroxychloroquineplaceboLow risk of bias -
Vermont, 1975   hydroxychloroquineplaceboLow risk of bias -
Massachusetts-II, 1976   HydroxychloroquineplaceboExploratory suggesting-88%-100%
Cooke, 1977   HydroxychloroquineplaceboExploratory negative-17%150%
Hume-A, 1977   HydroxychloroquineplaceboExploratory negative0%
Stockholm-II, 1981   HydroxychloroquineplaceboExploratory negative3%
Danish-A , 1976   HydroxychloroquineplaceboExploratory negative-24%-65%
Danish-B , 1976   HydroxychloroquineplaceboExploratory suggesting-60%∞%
Wood , 1973   RA233placeboExploratory negative43%
Athens, 1981   spplaceboLow risk of bias -
aspirin  
Clagett, 1975   aspirincontrolRisk of bias -
Zekert VI, 1982   aspirincontrolRisk of bias -
Pasteyer, 1977   Aspirinno treatmentExploratory negative0%-100%
Rocha, 1986   Aspirinno treatmentExploratory suggesting-86%-100%
Stockholm-I, 1975   AspirinplaceboExploratory negative68%
Harris-I, 1977   AspirinplaceboLow risk of bias suggesting-51%-100%
McKenna-I, 1980   AspirinplaceboExploratory suggesting-56%-63%
Sautter, 1983   AspirinplaceboExploratory suggesting-28%-55%
McBride, 1983   AspirinplaceboExploratory negative5%
Zekert-I , 1974   AspirinplaceboExploratory suggesting-58%-66%
Powers , 1976   AspirinplaceboExploratory suggesting-11%-100%
Erfurt-B , 1979   AspirinplaceboExploratory negative-20%
PEP hip-fracture, 2000     aspirinplaceboLow risk of bias suggesting -29%-26%
MRC, 1972   aspirinplaceboLow risk of bias negative25%
Loew DVT, 1974   aspirinplaceboLow risk of bias -
Erfurt-A, 1979   aspirinplaceboLow risk of bias -
Zekert V, 1980   aspirinplaceboLow risk of bias -
Vinazzer I, 1980   aspirinplaceboLow risk of bias -
Vinazzer II, 1977   aspirinplaceboLow risk of bias -
PEP elective arthroplasty, 2000   aspirinplaceboLow risk of bias -
dipyridamol  
Chicago, 1982   aspirin + dipyridamolcontrolExploratory negative-38%
Parodi I, 1973   dipyridamol + aspirincontrolExploratory suggesting-63%
Parodi II, 1973   dipyridamol + aspirincontrolRisk of bias -
Zekert-III, 1977   dipyridamol + aspirincontrolRisk of bias -
Australian I, 1975   dipyridamol + aspirincontrolRisk of bias -
Australian II, 1976   dipyridamol + aspirincontrolRisk of bias -
Toulouse I, 1979   dipyridamol + aspirincontrolRisk of bias -
Harjola DVT, 1982   dipyridamol + aspirincontrolRisk of bias -
Weiss, 1977   dipyridamol + aspirincontrolExploratory -
Lyon-I, 1975   aspirin + dipyridamolno treatmentExploratory suggesting-88%
Morris-B , 1977   aspirin + dipyridamolno treatmentExploratory negative-5%
Morris-A , 1977   dipyridamolno treatmentExploratory negative-6%
Hamburg, 1976   aspirin + dipyridamolplaceboExploratory negative-61%
Encke-II , 1976   aspirin + dipyridamolplaceboExploratory negative29%-26%
Frankfurt, 1981   aspirin + dipyridamolplaceboLow risk of bias negative100%
Encke IA, 1976   dipyridamol + aspirinplaceboLow risk of bias -
Encke IB, 1976   dipyridamol + aspirinplaceboLow risk of bias -
suloctidil  
Turpie, 1985   SuloctidilplaceboLow risk of bias -
ticlopidine  
Lasierra, 1982   ticlopidineplaceboLow risk of bias -
Walker, 1974   ticlopidineplaceboLow risk of bias -
McKenna-II , 1983   ticlopidineplaceboLow risk of bias negative100%-100%
McKenna-II, 1983   TiclopidineplaceboExploratory negative-13%-33%
Lyon-II   TiclopidineplaceboExploratory negative-38%∞%
Gardecki   TiclopidineplaceboExploratory negative-12%-68%
UFH  
Morris, 1974     UFHno treatmentsuggesting-81%
Welin-Berger, 1982   UFHno treatmentnegative33%
Bergqvist , 1979   UFHno treatmentsuggesting-29%38%
VTCSG, 1975   UFHno treatmentnegative
Mannucci , 1976   UFHno treatmentsuggesting-69%
Dechavanne, 1974   UFHno treatmentsuggesting-85%∞%
Dechavanne, 1975   UFHno treatmentsuggesting-87%
Bergqvist, 1979   UFHno treatmentsuggesting-35%
Galasko , 1976   UFHno treatmentsuggesting-64%
Gallus , 1973   UFHno treatmentsuggesting-73%
Morris , 1977   UFHno treatmentnegative-25%
Williams , 1978   UFHplacebonegative 280%
Abraham-Inpijn , 1975   UFHplacebonegative-78%-100%
Hampson, 1974     UFHplacebonegative-35%
Moskovitz, 1978   UFHplacebosuggesting-62%174%
Lahnborg, 1980   UFHplacebosuggesting-47%∞%
Xabregas , 1977   UFHplacebonegative-100%
Moskovitz, 1978   UFHplacebonegative-1%∞%
Svend-Hansen, 1981   UFHplacebosuggesting-46%

antithrombotics  

not classified  
Veth, 1985   spcontrolRisk of bias -
Cohen (L8405), 2007     compression stocking groupcontrol (on top fondaparinux)hip surgeryRisk of bias negative
SAVE-HIP1, 2012      NCTsemuloparinenoxaparinhip surgerysuggesting-43%
SAVE-KNEE, 2012      NCTsemuloparinenoxaparinknee surgerynegative-13%
SAVE-HIP 2, 2012      NCTsemuloparinenoxaparinhip surgerynegative-23%
EXCLAIM, 2010      NCTExtended-duration prophylaxiserrormedical patientsLow risk of bias suggesting
Borsgtrom, 1965   no treatment -
Mocris-C , 1977   Flurbiprofenno treatmentExploratory negative8%
Massachusetts-I , 1981   Hydroxychloroquineno treatmentExploratory negative-100%
Denver-Il , 1980   dipyridamol + ASAplaceboLow risk of bias negative-86%-100%
Valle , 1988   fluxumplacebonegative
Massachusetts-II, 1976   HydroxychloroquineplaceboExploratory suggesting-88%-100%
Cooke, 1977   HydroxychloroquineplaceboExploratory negative-17%150%
Hume-A, 1977   HydroxychloroquineplaceboExploratory negative0%
Stockholm-II, 1981   HydroxychloroquineplaceboExploratory negative3%
Danish-A , 1976   HydroxychloroquineplaceboExploratory negative-24%-65%
Danish-B , 1976   HydroxychloroquineplaceboExploratory suggesting-60%∞%
Carter IA, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter IB, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter II, 1974   hydroxychloroquineplaceboLow risk of bias -
New York, 1977   hydroxychloroquineplaceboLow risk of bias -
Vermont, 1975   hydroxychloroquineplaceboLow risk of bias -
Dahan, 1986   Pharmukaplacebomedical patientsLow risk of bias suggesting-67%
Wood , 1973   RA233placeboExploratory negative43%
Athens, 1981   spplaceboLow risk of bias -
Marlovits, 2007     extended-duration thromboprophylaxisstandard-duration thromboprophylaxisRisk of bias suggesting
DRIVE, 2008    NCTSR123781Aenoxaparinhip surgeryLow risk of bias -
PENTHIFRA–PLUS (Eriksson), 2003     extended prophylaxisstandard prophylaxiship surgeryLow risk of bias -
Lausen, 1998   extended prophylaxisstandard prophylaxisnegative
ENOXACAN II (Bergqvist), 2002     extended prophylaxisstandard prophylaxisLow risk of bias suggesting
FAME (Rasmussen), 2006     extended prophylaxisstandard prophylaxissuggesting
Limmer, 1994   antixarinunfractionated heparingeneral surgery -
Chiapuzzo , 1988   fluxumUnfractionated heparinhip surgerynegative-29%
Pini , 1989   fluxumUnfractionated heparinhip surgerynegative-31%
Catania, 1988   parnaparinunfractionated heparinabdominal surgerynegative
Salcuni, 1988   parnaparinunfractionated heparinabdominal surgerynegative
Verardi, 1989   parnaparinunfractionated heparinabdominal surgerynegative
Garcea, 1992   parnaparinunfractionated heparinabdominal surgery -
ToÈrngren, 1984   SSHAunfractionated heparingeneral surgerynegative
acenocoumarol  
Hamulyak, 1994   AcenocoumarolNadroparinnegative18%
Samama, 2001     AcenocoumarolReviparinnegative 35%
van Geloven, 1977   Acenocoumarolunfractionated heparinLow risk of bias -
apixaban  
ADOPT, 2011      NCTapixabanenoxaparinmedical patientsLow risk of bias suggesting
ADVANCE 3, 2010    NCTapixabanenoxaparinhip surgeryLow risk of bias suggesting-68%-60%
ADVANCE 2, 2010      NCTapixabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting-40%
APROPOS 2.5mg, 2007    NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
ardeparin  
Levine, 1996   ardeparinplaceboknee surgeryLow risk of bias suggesting
Heit, 2000     out of hospital Ardeparinstandard prophylaxisnegative
Godwin, 1993   ardeparinunfractionated heparinabdominal surgery -
aspirin  
Clagett, 1975   aspirincontrolRisk of bias -
Zekert VI, 1982   aspirincontrolRisk of bias -
Pasteyer, 1977   Aspirinno treatmentExploratory negative0%-100%
Rocha, 1986   Aspirinno treatmentExploratory suggesting-86%-100%
PEP hip-fracture, 2000     aspirinplaceboLow risk of bias suggesting -29%-26%
Stockholm-I, 1975   AspirinplaceboExploratory negative68%
Harris-I, 1977   AspirinplaceboLow risk of bias suggesting-51%-100%
McKenna-I, 1980   AspirinplaceboExploratory suggesting-56%-63%
Sautter, 1983   AspirinplaceboExploratory suggesting-28%-55%
McBride, 1983   AspirinplaceboExploratory negative5%
Zekert-I , 1974   AspirinplaceboExploratory suggesting-58%-66%
Powers , 1976   AspirinplaceboExploratory suggesting-11%-100%
Erfurt-B , 1979   AspirinplaceboExploratory negative-20%
MRC, 1972   aspirinplaceboLow risk of bias negative25%
Loew DVT, 1974   aspirinplaceboLow risk of bias -
Erfurt-A, 1979   aspirinplaceboLow risk of bias -
Zekert V, 1980   aspirinplaceboLow risk of bias -
Vinazzer I, 1980   aspirinplaceboLow risk of bias -
Vinazzer II, 1977   aspirinplaceboLow risk of bias -
PEP elective arthroplasty, 2000   aspirinplaceboLow risk of bias -
betrixaban  
APEX, 2016    NCTbetrixabanenoxaparinmedical patientsLow risk of bias suggesting
candesartan  
Ericksson, 1997     desirudinenoxaparinLow risk of bias -
REVASC, 1997     desirudinUFH -
Eriksson, 1996   desirudinUFHLow risk of bias -
Certoparin  
Kock, 1995   certoparincontrolRisk of bias negative
CERTIFY, 2010   certoparinUFHmedical patients -
Schmitz-Huebner, 1984   certoparinunfractionated heparinabdominal surgerynegative
Sasahara, 1986   certoparinunfractionated heparinabdominal surgerysuggesting
Voigt, 1986   certoparinunfractionated heparinabdominal surgerynegative
Welzel, 1988   certoparinunfractionated heparinabdominal surgerysuggesting
Kakkar, 1989   certoparinunfractionated heparinabdominal surgerynegative
Adolf, 1989   certoparinunfractionated heparinabdominal surgerynegative
Heilmann, 1989   certoparinunfractionated heparingynaecological surgerynegative
Baumgartner, 1989   certoparinunfractionated heparinabdominal surgerynegative
Hoffmann and Largiade, 1990   certoparinunfractionated heparinabdominal surgerynegative
Koppenhagen, 1990   certoparinunfractionated heparinabdominal surgery -
Schielke, 1991   certoparinunfractionated heparinabdominal surgery -
Koppenhagen, 1992   certoparinunfractionated heparinabdominal surgery -
Hoffmann and Largiader, 1992   certoparinunfractionated heparinabdominal surgery -
Heilmann, 1997   certoparinunfractionated heparingynaecological surgery -
Haas, 1999   certoparinunfractionated heparingeneral surgery -
Haas , 1987   certoparine + DHEUnfractionated heparinhip surgerynegative 0%
Lassen, 1988   certoparine + DHEUnfractionated heparinhip surgeryLow risk of bias suggesting6%
Lassen, 1989   certoparine + DHEUnfractionated heparinhip surgeryLow risk of bias negative-36%
dabigatran  
RE-NOVATE (150mg), 2007      NCTdabigatran 150mgenoxaparinhip surgeryLow risk of bias negative -67%
RE-NOVATE (220mg), 2007      NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative70%
RE-NOVATE 2    NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative
RE-MODEL (150mg), 2007     dabigatran 150mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative∞%
RE-MODEL (220mg), 2007   dabigatran 220mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative
RE-MOBILIZE (150mg), 2008     dabigatran 150mgenoxaparin (US regimen)knee surgeryLow risk of bias negative -100%
RE-MOBILIZE (220mg), 2008     dabigatran 220mgenoxaparin (US regimen)knee surgeryLow risk of bias negative
dalteparin  
Jorgensen, 1989   dalteparinplacebohip surgeryLow risk of bias suggesting-48%
Torholm, 1991     dalteparinplacebohip surgeryLow risk of bias suggesting-56%
Leizorovicz, 2004     dalteparinplacebomedical patientsLow risk of bias suggesting-51%
Ockelford , 1989   dalteparinplacebosuggesting
Lapidus, 2007     dalteparinplaceboLow risk of bias negative
Lapidus, 2007     dalteparinplaceboLow risk of bias negative
D-KAf (Selby), 2007      NCTdalteparinplacebonegative
Eriksson , 1988   dalteparinDextranhip surgerysuggesting-55%
Matzsch , 1988   dalteparinDextranhip surgerynegative-26%
Matzsch , 1991   dalteparinDextranhip surgerysuggesting-37%
Dahl, 1997   out of hospital Dalteparinstandard prophylaxissuggesting
Lassen, 1998     out of hospital Dalteparinstandard prophylaxisnegative
Hull, 2000     out of hospital Dalteparinstandard prophylaxissuggesting
PROTECT, 2011    NCTdalteparinUFHmedical patientsLow risk of bias suggesting-14%
Scala, 1990   dalteparinUFHRisk of bias negative
Haas , 1985   dalteparinUnfractionated heparinhip surgerynegative-14%
Binsack , 1986   dalteparinUnfractionated heparinhip surgerynegative-18%
Barre , 1987   dalteparinUnfractionated heparinhip surgerynegative75%
Dechavanne , 1989   dalteparinUnfractionated heparinhip surgerynegative-39%
Eriksson , 1989   dalteparinUnfractionated heparinhip surgerysuggesting-22%
Monreal , 1989   dalteparinUnfractionated heparinhip surgerynegative123%
Bergqvist, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Onarheim, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Koller, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Koller, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Fricker, 1988   dalteparinunfractionated heparinabdominal surgerynegative
Bergqvist, 1988   dalteparinunfractionated heparinabdominal surgerynegative
Caen, 1988   dalteparinunfractionated heparinabdominal surgerynegative
Borstad, 1988   dalteparinunfractionated heparingynaecological surgerynegative
Briel, 1988   dalteparinunfractionated heparinnon orthopedic surgerynegative
Creperio, 1990   dalteparinunfractionated heparingeneral surgerynegative
Hartl, 1990   dalteparinunfractionated heparinabdominal surgerysuggesting
Borstad, 1992   dalteparinunfractionated heparingynaecological surgery -
Kakkar, 1993   dalteparinunfractionated heparinabdominal surgery -
deltaparin  
Michot, 2002     deltaparincontrolRisk of bias suggesting
dipyridamol  
Chicago, 1982   aspirin + dipyridamolcontrolExploratory negative-38%
Parodi I, 1973   dipyridamol + aspirincontrolExploratory suggesting-63%
Parodi II, 1973   dipyridamol + aspirincontrolRisk of bias -
Zekert-III, 1977   dipyridamol + aspirincontrolRisk of bias -
Australian I, 1975   dipyridamol + aspirincontrolRisk of bias -
Australian II, 1976   dipyridamol + aspirincontrolRisk of bias -
Toulouse I, 1979   dipyridamol + aspirincontrolRisk of bias -
Harjola DVT, 1982   dipyridamol + aspirincontrolRisk of bias -
Weiss, 1977   dipyridamol + aspirincontrolExploratory -
Lyon-I, 1975   aspirin + dipyridamolno treatmentExploratory suggesting-88%
Morris-B , 1977   aspirin + dipyridamolno treatmentExploratory negative-5%
Morris-A , 1977   dipyridamolno treatmentExploratory negative-6%
Hamburg, 1976   aspirin + dipyridamolplaceboExploratory negative-61%
Encke-II , 1976   aspirin + dipyridamolplaceboExploratory negative29%-26%
Frankfurt, 1981   aspirin + dipyridamolplaceboLow risk of bias negative100%
Encke IA, 1976   dipyridamol + aspirinplaceboLow risk of bias -
Encke IB, 1976   dipyridamol + aspirinplaceboLow risk of bias -
edoxaban  
STARS J-V    NCTedoxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting
enoxaparin  
Canata, 2003   enoxaparincontrolExploratory negative
Warwick, 1995     enoxaparinno treatmenthip surgerynegative
Ho [43]   enoxaparinno treatmentnegative
Turpie, 1986   enoxaparinplacebohip surgeryLow risk of bias suggesting-71%
Leclerc, 1991   enoxaparinplaceboknee surgeryLow risk of bias suggesting-71%
Samama, 1997     enoxaparinplacebohip surgeryLow risk of bias suggesting
Kalodiki, 1996   enoxaparinplacebohip surgeryLow risk of bias -
MEDENOX, 1999     Enoxaparinplacebomedical patientsLow risk of bias suggesting-28%
Lederle, 2006     Enoxaparinplacebomedical patientsLow risk of bias negative
LIFENOX, 2011      NCTenoxaparinplacebomedical patientsLow risk of bias negative
LeGagneux , 1987   enoxaparinplacebonegative
Agnelli, 1998     enoxaparinplacebosuggesting
Melon, 1987   enoxaparinplacebonegative
DES Group , 1991   enoxaparinDextranhip surgerysuggesting-69%
Bergqvist, 1996     out of hospital Enoxaparinstandard prophylaxissuggesting
Planes, 1996     out of hospital Enoxaparinstandard prophylaxisnegative
Comp, 2001     out of hospital Enoxaparinstandard prophylaxissuggesting
Bergmann and Neuhart, 1996   enoxaparinUFHmedical patientsLow risk of bias negative-6%
Lechler, 1996   enoxaparinUFHmedical patientsLow risk of bias negative-75%
Kleber, 2003     enoxaparinUFHmedical patientsnegative-23%
Planes , 1988   enoxaparinUnfractionated heparinhip surgerysuggesting-49%
Levine , 1991   enoxaparinUnfractionated heparinhip surgerynegative-10%
Samama 1, 1988   enoxaparinunfractionated heparingeneral surgerynegative
Samama 2, 1988   enoxaparinunfractionated heparingeneral surgerynegative
Samama 3, 1988   enoxaparinunfractionated heparingeneral surgerynegative
Kaaja, 1992   enoxaparinunfractionated heparingynaecological surgery -
Gazzaniga (ISG), 1993   enoxaparinunfractionated heparingeneral surgery -
Nurmohamed, 1995   enoxaparinunfractionated heparingeneral surgery -
McLeod (Canadian), 1995   enoxaparinunfractionated heparinabdominal surgery -
Gonzalez, 1996   enoxaparinunfractionated heparinabdominal surgery -
ENOXACAN, 1997   enoxaparinunfractionated heparinabdominal surgery -
fondaparinux  
DRI4757   fondaparinuxplaceboknee surgeryLow risk of bias -
ARTEMIS (Cohen), 2006     fondaparinuxplacebomedical patientsLow risk of bias negative
APOLLO (Turpie), 2007     fondaparinuxplacebo (on top intermittent pneumatic comp.)abdominal surgeryLow risk of bias suggesting -69%
PENTAMAKS (Bauer), 2001     fondaparinuxenoxaparinknee surgeryLow risk of bias suggesting -54%-75%
PENTHIFRA (Eriksson), 2001     fondaparinuxenoxaparinhip surgeryLow risk of bias suggesting-58%1%
PENTATHLON (Turpie), 2002     fondaparinuxenoxaparinhip surgeryLow risk of bias suggesting -31%∞%
EPHESUS (Lassen), 2002     fondaparinuxenoxaparinhip surgeryLow risk of bias suggesting-56%-34%
Turpie, 2001     fondaparinuxenoxaparinhip surgeryLow risk of bias -
L8541   fondaparinuxenoxaparinorthopaedic surgeryLow risk of bias negative-75%
L8635   fondaparinuxenoxaparinknee surgeryExploratory negative
BRiEF    NCTfondaparinuxenoxaparinmedical patients -
PEGASUS, 2005     fondaparinuxenoxaparinabdominal surgeryLow risk of bias negative-28%∞%
fraxiparin  
Roth, 1995   nadroparincontrolnegative
Pezzuoli, 1989   nadroparinplacebosuggesting
Leyvraz, 1991   nadroparinUnfractionated heparinhip surgerynegative-20%
LMWH  
Harenberg, 1990     LMWHUFHmedical patientsLow risk of bias negative-30%
Harenberg, 1996   LMWHUFHmedical patientsLow risk of bias negative 189%
nadroparin  
KANT (7 days), 2008   nadroparincontrolRisk of bias suggesting
Kujath, 1993   nadroparincontrolRisk of bias suggesting
KANT (14 days), 2008   nadroparin 14dcontrolRisk of bias suggesting
Yoo, 1997     nadroparinno treatmenthip surgerynegative
Marassi [41]   nadroparinno treatmentnegative
Sourmelis, 1995   nadroparinplacebohip surgeryLow risk of bias suggesting
Fraisse, 2000     Nadroparinplacebomedical patientsLow risk of bias negative-45%
Mahe, 2005   Nadroparinplacebomedical patientsLow risk of bias negative
Bergmann, 1996   nadroparinplacebomedical patientsnegative
Balas [40]   nadroparinplacebonegative
Nurmohamed, 1996   nadroparinplacebonegative
NPHDO, 1998   out of hospital Nadroparinstandard prophylaxisnegative
Kakkar and Murray, 1985   nadroparinunfractionated heparingeneral surgerysuggesting
EFS, 1988   nadroparinunfractionated heparinabdominal surgerysuggesting
Dahan, 1989   nadroparinunfractionated heparinthoracic surgerynegative
Barbui, 1990   nadroparinunfractionated heparingeneral surgery -
Eurin, 1994   nadroparinunfractionated heparinabdominal surgery -
phenindione  
Eskeland, 1966   Phenindioneno treatment -
Hamilton, 1970     Phenindioneno treatment -
reviparin  
Wirth, 2001     reviparincontrolLow risk of bias negative
Lassen, 2002     reviparinplaceboLow risk of bias suggesting
Kakkar, 1993   reviparinunfractionated heparingeneral surgery -
rivaroxaban  
MARINER, 2018        NCTrivaroxabanplacebomedical patientsLow risk of bias suggesting
RECORD 1, 2008      NCTrivaroxabanenoxaparinhip surgeryLow risk of bias suggesting-77%291%
RECORD 3, 2008    NCTrivaroxabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting-47%-100%
ODIXa-HIP 10mg, 2006   rivaroxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting-58%
RECORD 2, 2008    NCTrivaroxaban (long duration)enoxaparin (short duration)hip surgeryLow risk of bias suggesting-80%-75%
ODIXa-KNEE, 2005   rivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
RECORD 4, 2009    NCTrivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting-51%
suloctidil  
Turpie, 1985   SuloctidilplaceboLow risk of bias -
ticlopidine  
McKenna-II, 1983   TiclopidineplaceboExploratory negative-13%-33%
Lyon-II   TiclopidineplaceboExploratory negative-38%∞%
Gardecki   TiclopidineplaceboExploratory negative-12%-68%
McKenna-II , 1983   ticlopidineplaceboLow risk of bias negative100%-100%
Lasierra, 1982   ticlopidineplaceboLow risk of bias -
Walker, 1974   ticlopidineplaceboLow risk of bias -
tinzaparin  
Jorgensen, 2002     tinzaparincontrolRisk of bias negative
Lassen, 1991   tinzaparinplacebohip surgeryLow risk of bias suggesting-32%
Bergqvist [42]   tinzaparinplacebonegative
Leizorovicz, 1991   tinzaparinunfractionated heparinabdominal surgery -
UFH  
Blech, 1981   UFHcontrolmedical patientssuggesting-85%
Cade   UFHcontrolmedical patients -
Gardlund, 1996   UFHcontrolmedical patientssuggesting34%
Handley (low dose), 1972   UFHcontrolRisk of bias negative-100%
Handley, 1972   UFHcontrolRisk of bias negative
Gallus, 1973   UFHcontrolRisk of bias negative
Emerson, 1973   UFHcontrolRisk of bias suggesting-84%
Zawilska, 1989   UFHcontrolRisk of bias suggesting-79%
Warlow, 1973     UFHcontrolLow risk of bias suggesting-84%
Morris, 1974     UFHno treatmentsuggesting-81%
Welin-Berger, 1982   UFHno treatmentnegative33%
Bergqvist , 1979   UFHno treatmentsuggesting-29%38%
VTCSG, 1975   UFHno treatmentnegative
Mannucci , 1976   UFHno treatmentsuggesting-69%
Dechavanne, 1974   UFHno treatmentsuggesting-85%∞%
Dechavanne, 1975   UFHno treatmentsuggesting-87%
Bergqvist, 1979   UFHno treatmentsuggesting-35%
Galasko , 1976   UFHno treatmentsuggesting-64%
Gallus , 1973   UFHno treatmentsuggesting-73%
Morris , 1977   UFHno treatmentnegative-25%
Kakkar (IMT)     UFHno treatment -
Gruber     UFHno treatment -
Gordon-Smith, 1972   UFHno treatment -
Nicolaides, 1972     UFHno treatment -
Multiunit, 1974   UFHno treatment -
Abernethy, 1974   UFHno treatment -
Clarke-Pearson, 1983   UFHno treatment -
Plante, 1979     UFHno treatment -
Abraham-Inpijn, 1979   UFHno treatment -
Spebar, 1981   UFHno treatment -
Sagar, 1974     UFHno treatment -
Koppenhagen, 1982   UFHno treatment -
Bergqvist, 1980   UFHno treatment -
Gallus, 1973   UFHno treatment -
Gallus, 1976   UFHno treatment -
Groote Schuur, 1979   UFHno treatment -
Kraytman, 1976   UFHno treatment -
Kraytman, 1977   UFHno treatment -
Kettunen, 1974   UFHno treatment -
Caloghera, 1984   UFHno treatment -
Marchelli, 1983   UFHno treatment -
Ziemski, 1979   UFHno treatment -
Coe, 1978   UFHno treatment -
Sebeseri, 1975   UFHno treatment -
Allen, 1978   UFHno treatment -
Cerrato, 1978   UFHno treatmentsuggesting
Williams , 1978   UFHplacebonegative 280%
Abraham-Inpijn , 1975   UFHplacebonegative-78%-100%
Lowe , 1981     UFHplacebosuggesting-58%-62%
Hampson, 1974     UFHplacebonegative-35%
Moskovitz, 1978   UFHplacebosuggesting-62%174%
Lahnborg, 1980   UFHplacebosuggesting-47%∞%
Xabregas , 1977   UFHplacebonegative-100%
Moskovitz, 1978   UFHplacebonegative-1%∞%
Svend-Hansen, 1981   UFHplacebosuggesting-46%
Kakkar, 1972     UFHplacebo -
Kiil, 1978     UFHplacebo -
Torngren, 1978   UFHplacebo -
Torngren   UFHplacebo -
Lahnborg, 1975   UFHplacebo -
Lahnborg, 1976     UFHplacebo -
Covey, 1975   UFHplacebo -
Belch, 1980   UFHplacebo -
Taberner, 1978   UFHplacebo -
Strand, 1975   UFHplacebo -
Roberts, 1975   UFHplacebo -
Ribaudo, 1975   UFHplacebo -
Wu, 1977   UFHplacebo -
Lawrence, 1977   UFHplacebo -
Muiticentre, 1984   UFHplacebo -
Jourdan, 1984   UFHplacebo -
Torngren, 1978   UFHplacebo -
Kruse-Blinkenberg, 1980   UFHplacebo -
Kraytman, 1977   UFHplacebo -
Marchetti, 1982   UFHplacebo -
Bejjani, 1983   UFHplacebo -
Hedlund, 1979   UFHplacebo -
Kutnowski, 1977   UFHplacebo -
Vandendris, 1980   UFHplacebo -
Pitt, 1980   UFHplaceboRisk of bias negative-53%
Loew, 1977   UFHaspirin -
Vinazzer, 1980   UFHaspirin -
Muiticentre 53,S4, 1984   UFHDHE -
Muiticentre, 1984   UFHDHE -
van Geloven, 1977   UFHoral anticoagulant -
Manganelli, 1998     out of hospital UFHstandard prophylaxisnegative
warfarin  
Pinto, 1970   Warfarinno treatment -
Hume, 1973   Warfarinno treatment -
Morris, 1976     Warfarinno treatment -
Powers, 1989   Warfarinno treatment -
Myrhe, 1969   WarfarinplaceboLow risk of bias -
RD Heparin, 1994   WarfarinArdeparinsuggesting44%
Heit, 1997   WarfarinArdeparinLow risk of bias suggesting31%
Powers, 1989   WarfarinAspirin -
Lotke, 1997     WarfarinAspirin -
Francis, 1997     WarfarinDalteparinsuggesting77%
Hull, 2000     WarfarinDalteparinLow risk of bias suggesting 102%
Gerhart, 1991   WarfarinDanaparoid -
van Comp, 1998   WarfarinDanaparoid -
Myrhe, 1969   WarfarinDextranLow risk of bias -
Harris, 1972   WarfarinDextran -
Barber, 1977   WarfarinDextran -
Francis, 1983   WarfarinDextran -
Leclerc, 1996     WarfarinEnoxaparinLow risk of bias suggesting40%
Colwell, 1999     WarfarinEnoxaparinsuggesting407%
Fitzgerald, 2001     WarfarinEnoxaparinsuggesting 51%
Paiement, 1987   WarfarinIntermittent pneumatic compression -
Bailey, 1991   WarfarinIntermittent pneumatic compression -
Kaempffe, 1991     WarfarinIntermittent pneumatic compression -
Francis, 1992   WarfarinIntermittent pneumatic compression -
Hull, 1993     WarfarinLogiparinLow risk of bias suggesting19%
Hume, 1973   WarfarinSudoxicam -
Hume, 1973   Warfarinunfractionated heparin -
Barber, 1977   Warfarinunfractionated heparin -
ximelagatran  
METHRO I, 2002   ximelagatranDalteparinnegative
METHRO II, 2002     ximelagatranDalteparinLow risk of bias suggesting
Phase II (Heit), 2001     ximelagatranEnoxaparinLow risk of bias negative
Platinum (Colwell), 2003   ximelagatranEnoxaparinLow risk of bias negative
METHRO III, 2002         ximelagatranEnoxaparinLow risk of bias negative
EXPRESS, 2003     ximelagatranEnoxaparinLow risk of bias suggesting

direct antithrombins  

dabigatran  
RE-NOVATE (150mg), 2007      NCTdabigatran 150mgenoxaparinhip surgeryLow risk of bias negative -67%
RE-NOVATE (220mg), 2007      NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative70%
RE-NOVATE 2    NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative
RE-MODEL (150mg), 2007     dabigatran 150mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative∞%
RE-MODEL (220mg), 2007   dabigatran 220mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative
RE-MOBILIZE (150mg), 2008     dabigatran 150mgenoxaparin (US regimen)knee surgeryLow risk of bias negative -100%
RE-MOBILIZE (220mg), 2008     dabigatran 220mgenoxaparin (US regimen)knee surgeryLow risk of bias negative
ximelagatran  
METHRO I, 2002   ximelagatranDalteparinnegative
METHRO II, 2002     ximelagatranDalteparinLow risk of bias suggesting
Phase II (Heit), 2001     ximelagatranEnoxaparinLow risk of bias negative
Platinum (Colwell), 2003   ximelagatranEnoxaparinLow risk of bias negative
METHRO III, 2002         ximelagatranEnoxaparinLow risk of bias negative
EXPRESS, 2003     ximelagatranEnoxaparinLow risk of bias suggesting

direct factor Xa inhibitors  

apixaban  
ADVANCE 3, 2010    NCTapixabanenoxaparinhip surgeryLow risk of bias suggesting-68%-60%
ADVANCE 2, 2010      NCTapixabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting-40%
APROPOS 2.5mg, 2007    NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
ADVANCE-1, 2008      NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting-5%
edoxaban  
STARS J-V    NCTedoxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting
rivaroxaban  
RECORD 1, 2008      NCTrivaroxabanenoxaparinhip surgeryLow risk of bias suggesting-77%291%
RECORD 3, 2008    NCTrivaroxabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting-47%-100%
ODIXa-HIP 10mg, 2006   rivaroxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting-58%
RECORD 2, 2008    NCTrivaroxaban (long duration)enoxaparin (short duration)hip surgeryLow risk of bias suggesting-80%-75%
ODIXa-KNEE, 2005   rivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
RECORD 4, 2009    NCTrivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting-51%

direct oral anticoagulant (DAO)  

apixaban  
ADOPT, 2011      NCTapixabanenoxaparinmedical patientsLow risk of bias suggesting
ADVANCE 3, 2010    NCTapixabanenoxaparinhip surgeryLow risk of bias suggesting-68%-60%
ADVANCE 2, 2010      NCTapixabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting-40%
APROPOS 2.5mg, 2007    NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
ADVANCE-1, 2008      NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting-5%
betrixaban  
APEX, 2016    NCTbetrixabanenoxaparinmedical patientsLow risk of bias suggesting
dabigatran  
RE-NOVATE (150mg), 2007      NCTdabigatran 150mgenoxaparinhip surgeryLow risk of bias negative -67%
RE-NOVATE (220mg), 2007      NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative70%
RE-NOVATE 2    NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative
RE-MODEL (150mg), 2007     dabigatran 150mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative∞%
RE-MODEL (220mg), 2007   dabigatran 220mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative
RE-MOBILIZE (150mg), 2008     dabigatran 150mgenoxaparin (US regimen)knee surgeryLow risk of bias negative -100%
RE-MOBILIZE (220mg), 2008     dabigatran 220mgenoxaparin (US regimen)knee surgeryLow risk of bias negative
edoxaban  
STARS J-V    NCTedoxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting
rivaroxaban  
MARINER, 2018        NCTrivaroxabanplacebomedical patientsLow risk of bias suggesting
RECORD 1, 2008      NCTrivaroxabanenoxaparinhip surgeryLow risk of bias suggesting-77%291%
RECORD 3, 2008    NCTrivaroxabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting-47%-100%
ODIXa-HIP 10mg, 2006   rivaroxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting-58%
RECORD 2, 2008    NCTrivaroxaban (long duration)enoxaparin (short duration)hip surgeryLow risk of bias suggesting-80%-75%
ODIXa-KNEE, 2005   rivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
RECORD 4, 2009    NCTrivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting-51%

graduated compression stockings  

not classified  
Cohen (L8405), 2007     compression stocking groupcontrol (on top fondaparinux)hip surgeryRisk of bias negative
*Scurr, 1977   GCSno prophylaxissuggesting-69%
Holford, 1976   GCSno prophylaxissuggesting-53%
Turner, 1984   GCSno prophylaxisnegative-100%
Turpie (GCS vs crtl), 1989   GCSno prophylaxisnegative-56%
Allan, 1983   GCSno prophylaxissuggesting-57%
*Tsapogas, 1971   GCSno prophylaxis -
Barnes, 1978     GCSno prophylaxisnegative∞%
*Ohlund, 1983   GCSno prophylaxis -
*Wille-Jorgensen, 1989     GCSno prophylaxis -
*Inada, 1983   GCSno prophylaxis -
CLOTS, 2009     GCSno prophylaxisRisk of bias negative-8%
Rosengarten, 1970   GCSno prophylaxisnegative0%
Turpie (IPD or GCS), 1989   IPD or GCSno prophylaxisnegative-55%
Muir, 2000     GCS + aspaspirinnegative-51%
Kierkegaard, 1993     GCS + aspaspirinnegative-100%
*Bergqvist, 1984   GCS + dextrandextrannegative-100%
Fredin, 1989   GCS + dextrandextrannegative-35%
Scurr (GCS+IPC vs IPC), 1987   GCS +IPCIPCnegative-86%
Mellbring, 1986   GCS +IPCIPCnegative17%
Camporese, 2008   GCSLMWHnegative 193%
Kalodiki (GCS+LMWH vs LMWH), 1996   GCS + LMWHLMWHnegative-35%
Porteous, 1989   Knee length GCSThigh length GCS -
Williams, 1988   Knee length GCSThigh length GCS -
Hui THR, 1996     Knee length GCSThigh length GCS -
Hui TKR, 1996     Knee length GCSThigh length GCS -
Howard, 2004     Knee length GCSThigh length GCS -
William, 1996   Knee length GCSThigh length GCS -
Rasmussen (GCS vs UFH), 1998   GCSUFHnegative1%
Fasting, 1985   GCSUFHnegative-6%
Hansberry (vs UFH), 1991   GCSUFHnegative150%
UFH  
Wille-Jorgensen, 1991   GCS + UFHUFHsuggesting-83%
Wille-Jorgensen, 1985   GCS + UFHUFHsuggesting-81%
*Rasmussen (adj), 1988   GCS + UFHUFHnegative-12%
Torngren, 1980   GCS + UFHUFHsuggesting-67%

heparin (UFH or LMWH)  

not classified  
FX140, Simonneau G, 2006     nadroparinenoxaparinknee surgery -
SAVE-HIP1, 2012      NCTsemuloparinenoxaparinhip surgerysuggesting-43%
SAVE-KNEE, 2012      NCTsemuloparinenoxaparinknee surgerynegative-13%
SAVE-HIP 2, 2012      NCTsemuloparinenoxaparinhip surgerynegative-23%
Valle , 1988   fluxumplacebonegative
Limmer, 1994   antixarinunfractionated heparingeneral surgery -
Chiapuzzo , 1988   fluxumUnfractionated heparinhip surgerynegative-29%
Pini , 1989   fluxumUnfractionated heparinhip surgerynegative-31%
Catania, 1988   parnaparinunfractionated heparinabdominal surgerynegative
Salcuni, 1988   parnaparinunfractionated heparinabdominal surgerynegative
Verardi, 1989   parnaparinunfractionated heparinabdominal surgerynegative
Garcea, 1992   parnaparinunfractionated heparinabdominal surgery -
ToÈrngren, 1984   SSHAunfractionated heparingeneral surgerynegative
ardeparin  
Levine, 1996   ardeparinplaceboknee surgeryLow risk of bias suggesting
Godwin, 1993   ardeparinunfractionated heparinabdominal surgery -
Certoparin  
Schmitz-Huebner, 1984   certoparinunfractionated heparinabdominal surgerynegative
Sasahara, 1986   certoparinunfractionated heparinabdominal surgerysuggesting
Voigt, 1986   certoparinunfractionated heparinabdominal surgerynegative
Welzel, 1988   certoparinunfractionated heparinabdominal surgerysuggesting
Kakkar, 1989   certoparinunfractionated heparinabdominal surgerynegative
Adolf, 1989   certoparinunfractionated heparinabdominal surgerynegative
Heilmann, 1989   certoparinunfractionated heparingynaecological surgerynegative
Baumgartner, 1989   certoparinunfractionated heparinabdominal surgerynegative
Hoffmann and Largiade, 1990   certoparinunfractionated heparinabdominal surgerynegative
Koppenhagen, 1990   certoparinunfractionated heparinabdominal surgery -
Schielke, 1991   certoparinunfractionated heparinabdominal surgery -
Koppenhagen, 1992   certoparinunfractionated heparinabdominal surgery -
Hoffmann and Largiader, 1992   certoparinunfractionated heparinabdominal surgery -
Heilmann, 1997   certoparinunfractionated heparingynaecological surgery -
Haas, 1999   certoparinunfractionated heparingeneral surgery -
Haas , 1987   certoparine + DHEUnfractionated heparinhip surgerynegative 0%
Lassen, 1988   certoparine + DHEUnfractionated heparinhip surgeryLow risk of bias suggesting6%
Lassen, 1989   certoparine + DHEUnfractionated heparinhip surgeryLow risk of bias negative-36%
dalteparin  
Jorgensen, 1989   dalteparinplacebohip surgeryLow risk of bias suggesting-48%
Torholm, 1991     dalteparinplacebohip surgeryLow risk of bias suggesting-56%
Ockelford , 1989   dalteparinplacebosuggesting
Eriksson , 1988   dalteparinDextranhip surgerysuggesting-55%
Matzsch , 1988   dalteparinDextranhip surgerynegative-26%
Matzsch , 1991   dalteparinDextranhip surgerysuggesting-37%
Haas , 1985   dalteparinUnfractionated heparinhip surgerynegative-14%
Binsack , 1986   dalteparinUnfractionated heparinhip surgerynegative-18%
Barre , 1987   dalteparinUnfractionated heparinhip surgerynegative75%
Dechavanne , 1989   dalteparinUnfractionated heparinhip surgerynegative-39%
Eriksson , 1989   dalteparinUnfractionated heparinhip surgerysuggesting-22%
Monreal , 1989   dalteparinUnfractionated heparinhip surgerynegative123%
Bergqvist, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Onarheim, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Koller, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Koller, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Fricker, 1988   dalteparinunfractionated heparinabdominal surgerynegative
Bergqvist, 1988   dalteparinunfractionated heparinabdominal surgerynegative
Caen, 1988   dalteparinunfractionated heparinabdominal surgerynegative
Borstad, 1988   dalteparinunfractionated heparingynaecological surgerynegative
Briel, 1988   dalteparinunfractionated heparinnon orthopedic surgerynegative
Creperio, 1990   dalteparinunfractionated heparingeneral surgerynegative
Hartl, 1990   dalteparinunfractionated heparinabdominal surgerysuggesting
Borstad, 1992   dalteparinunfractionated heparingynaecological surgery -
Kakkar, 1993   dalteparinunfractionated heparinabdominal surgery -
enoxaparin  
Ho [43]   enoxaparinno treatmentnegative
Warwick, 1995     enoxaparinno treatmenthip surgerynegative
Turpie, 1986   enoxaparinplacebohip surgeryLow risk of bias suggesting-71%
Leclerc, 1991   enoxaparinplaceboknee surgeryLow risk of bias suggesting-71%
Samama, 1997     enoxaparinplacebohip surgeryLow risk of bias suggesting
Kalodiki, 1996   enoxaparinplacebohip surgeryLow risk of bias -
Agnelli, 1998     enoxaparinplacebosuggesting
Melon, 1987   enoxaparinplacebonegative
DES Group , 1991   enoxaparinDextranhip surgerysuggesting-69%
Planes , 1988   enoxaparinUnfractionated heparinhip surgerysuggesting-49%
Levine , 1991   enoxaparinUnfractionated heparinhip surgerynegative-10%
Samama 1, 1988   enoxaparinunfractionated heparingeneral surgerynegative
Samama 2, 1988   enoxaparinunfractionated heparingeneral surgerynegative
Samama 3, 1988   enoxaparinunfractionated heparingeneral surgerynegative
Kaaja, 1992   enoxaparinunfractionated heparingynaecological surgery -
Gazzaniga (ISG), 1993   enoxaparinunfractionated heparingeneral surgery -
Nurmohamed, 1995   enoxaparinunfractionated heparingeneral surgery -
McLeod (Canadian), 1995   enoxaparinunfractionated heparinabdominal surgery -
Gonzalez, 1996   enoxaparinunfractionated heparinabdominal surgery -
ENOXACAN, 1997   enoxaparinunfractionated heparinabdominal surgery -
fraxiparin  
Pezzuoli, 1989   nadroparinplacebosuggesting
Leyvraz, 1991   nadroparinUnfractionated heparinhip surgerynegative-20%
nadroparin  
Yoo, 1997     nadroparinno treatmenthip surgerynegative
Marassi [41]   nadroparinno treatmentnegative
Balas [40]   nadroparinplacebonegative
Nurmohamed, 1996   nadroparinplacebonegative
Sourmelis, 1995   nadroparinplacebohip surgeryLow risk of bias suggesting
Kakkar and Murray, 1985   nadroparinunfractionated heparingeneral surgerysuggesting
EFS, 1988   nadroparinunfractionated heparinabdominal surgerysuggesting
Dahan, 1989   nadroparinunfractionated heparinthoracic surgerynegative
Barbui, 1990   nadroparinunfractionated heparingeneral surgery -
Eurin, 1994   nadroparinunfractionated heparinabdominal surgery -
reviparin  
Kakkar, 1993   reviparinunfractionated heparingeneral surgery -
tinzaparin  
Bergqvist [42]   tinzaparinplacebonegative
Lassen, 1991   tinzaparinplacebohip surgeryLow risk of bias suggesting-32%
Leizorovicz, 1991   tinzaparinunfractionated heparinabdominal surgery -
UFH  
Cerrato, 1978   UFHno treatmentsuggesting

LMWH  

not classified  
FX140, Simonneau G, 2006     nadroparinenoxaparinknee surgery -
SAVE-HIP1, 2012      NCTsemuloparinenoxaparinhip surgerysuggesting-43%
SAVE-KNEE, 2012      NCTsemuloparinenoxaparinknee surgerynegative-13%
SAVE-HIP 2, 2012      NCTsemuloparinenoxaparinhip surgerynegative-23%
Valle , 1988   fluxumplacebonegative
Dahan, 1986   Pharmukaplacebomedical patientsLow risk of bias suggesting-67%
Limmer, 1994   antixarinunfractionated heparingeneral surgery -
Chiapuzzo , 1988   fluxumUnfractionated heparinhip surgerynegative-29%
Pini , 1989   fluxumUnfractionated heparinhip surgerynegative-31%
Catania, 1988   parnaparinunfractionated heparinabdominal surgerynegative
Salcuni, 1988   parnaparinunfractionated heparinabdominal surgerynegative
Verardi, 1989   parnaparinunfractionated heparinabdominal surgerynegative
Garcea, 1992   parnaparinunfractionated heparinabdominal surgery -
ToÈrngren, 1984   SSHAunfractionated heparingeneral surgerynegative
ardeparin  
Levine, 1996   ardeparinplaceboknee surgeryLow risk of bias suggesting
Godwin, 1993   ardeparinunfractionated heparinabdominal surgery -
Certoparin  
CERTIFY, 2010   certoparinUFHmedical patients -
Schmitz-Huebner, 1984   certoparinunfractionated heparinabdominal surgerynegative
Sasahara, 1986   certoparinunfractionated heparinabdominal surgerysuggesting
Voigt, 1986   certoparinunfractionated heparinabdominal surgerynegative
Welzel, 1988   certoparinunfractionated heparinabdominal surgerysuggesting
Kakkar, 1989   certoparinunfractionated heparinabdominal surgerynegative
Adolf, 1989   certoparinunfractionated heparinabdominal surgerynegative
Heilmann, 1989   certoparinunfractionated heparingynaecological surgerynegative
Baumgartner, 1989   certoparinunfractionated heparinabdominal surgerynegative
Hoffmann and Largiade, 1990   certoparinunfractionated heparinabdominal surgerynegative
Koppenhagen, 1990   certoparinunfractionated heparinabdominal surgery -
Schielke, 1991   certoparinunfractionated heparinabdominal surgery -
Koppenhagen, 1992   certoparinunfractionated heparinabdominal surgery -
Hoffmann and Largiader, 1992   certoparinunfractionated heparinabdominal surgery -
Heilmann, 1997   certoparinunfractionated heparingynaecological surgery -
Haas, 1999   certoparinunfractionated heparingeneral surgery -
Haas , 1987   certoparine + DHEUnfractionated heparinhip surgerynegative 0%
Lassen, 1988   certoparine + DHEUnfractionated heparinhip surgeryLow risk of bias suggesting6%
Lassen, 1989   certoparine + DHEUnfractionated heparinhip surgeryLow risk of bias negative-36%
dalteparin  
Jorgensen, 1989   dalteparinplacebohip surgeryLow risk of bias suggesting-48%
Torholm, 1991     dalteparinplacebohip surgeryLow risk of bias suggesting-56%
Ockelford , 1989   dalteparinplacebosuggesting
Leizorovicz, 2004     dalteparinplacebomedical patientsLow risk of bias suggesting-51%
Eriksson , 1988   dalteparinDextranhip surgerysuggesting-55%
Matzsch , 1988   dalteparinDextranhip surgerynegative-26%
Matzsch , 1991   dalteparinDextranhip surgerysuggesting-37%
PROTECT, 2011    NCTdalteparinUFHmedical patientsLow risk of bias suggesting-14%
Bergqvist, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Onarheim, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Koller, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Koller, 1986   dalteparinunfractionated heparinabdominal surgerynegative
Fricker, 1988   dalteparinunfractionated heparinabdominal surgerynegative
Bergqvist, 1988   dalteparinunfractionated heparinabdominal surgerynegative
Caen, 1988   dalteparinunfractionated heparinabdominal surgerynegative
Borstad, 1988   dalteparinunfractionated heparingynaecological surgerynegative
Briel, 1988   dalteparinunfractionated heparinnon orthopedic surgerynegative
Creperio, 1990   dalteparinunfractionated heparingeneral surgerynegative
Hartl, 1990   dalteparinunfractionated heparinabdominal surgerysuggesting
Borstad, 1992   dalteparinunfractionated heparingynaecological surgery -
Kakkar, 1993   dalteparinunfractionated heparinabdominal surgery -
Haas , 1985   dalteparinUnfractionated heparinhip surgerynegative-14%
Binsack , 1986   dalteparinUnfractionated heparinhip surgerynegative-18%
Barre , 1987   dalteparinUnfractionated heparinhip surgerynegative75%
Dechavanne , 1989   dalteparinUnfractionated heparinhip surgerynegative-39%
Eriksson , 1989   dalteparinUnfractionated heparinhip surgerysuggesting-22%
Monreal , 1989   dalteparinUnfractionated heparinhip surgerynegative123%
enoxaparin  
Warwick, 1995     enoxaparinno treatmenthip surgerynegative
Ho [43]   enoxaparinno treatmentnegative
Agnelli, 1998     enoxaparinplacebosuggesting
Melon, 1987   enoxaparinplacebonegative
MEDENOX, 1999     Enoxaparinplacebomedical patientsLow risk of bias suggesting-28%
Lederle, 2006     Enoxaparinplacebomedical patientsLow risk of bias negative
LIFENOX, 2011      NCTenoxaparinplacebomedical patientsLow risk of bias negative
Turpie, 1986   enoxaparinplacebohip surgeryLow risk of bias suggesting-71%
Leclerc, 1991   enoxaparinplaceboknee surgeryLow risk of bias suggesting-71%
Samama, 1997     enoxaparinplacebohip surgeryLow risk of bias suggesting
Kalodiki, 1996   enoxaparinplacebohip surgeryLow risk of bias -
DES Group , 1991   enoxaparinDextranhip surgerysuggesting-69%
Bergmann and Neuhart, 1996   enoxaparinUFHmedical patientsLow risk of bias negative-6%
Lechler, 1996   enoxaparinUFHmedical patientsLow risk of bias negative-75%
Kleber, 2003     enoxaparinUFHmedical patientsnegative-23%
Samama 1, 1988   enoxaparinunfractionated heparingeneral surgerynegative
Samama 2, 1988   enoxaparinunfractionated heparingeneral surgerynegative
Samama 3, 1988   enoxaparinunfractionated heparingeneral surgerynegative
Kaaja, 1992   enoxaparinunfractionated heparingynaecological surgery -
Gazzaniga (ISG), 1993   enoxaparinunfractionated heparingeneral surgery -
Nurmohamed, 1995   enoxaparinunfractionated heparingeneral surgery -
McLeod (Canadian), 1995   enoxaparinunfractionated heparinabdominal surgery -
Gonzalez, 1996   enoxaparinunfractionated heparinabdominal surgery -
ENOXACAN, 1997   enoxaparinunfractionated heparinabdominal surgery -
Planes , 1988   enoxaparinUnfractionated heparinhip surgerysuggesting-49%
Levine , 1991   enoxaparinUnfractionated heparinhip surgerynegative-10%
fraxiparin  
Pezzuoli, 1989   nadroparinplacebosuggesting
Leyvraz, 1991   nadroparinUnfractionated heparinhip surgerynegative-20%
LMWH  
Harenberg, 1990     LMWHUFHmedical patientsLow risk of bias negative-30%
Harenberg, 1996   LMWHUFHmedical patientsLow risk of bias negative 189%
nadroparin  
Marassi [41]   nadroparinno treatmentnegative
Yoo, 1997     nadroparinno treatmenthip surgerynegative
Sourmelis, 1995   nadroparinplacebohip surgeryLow risk of bias suggesting
Balas [40]   nadroparinplacebonegative
Nurmohamed, 1996   nadroparinplacebonegative
Fraisse, 2000     Nadroparinplacebomedical patientsLow risk of bias negative-45%
Mahe, 2005   Nadroparinplacebomedical patientsLow risk of bias negative
Bergmann, 1996   nadroparinplacebomedical patientsnegative
Kakkar and Murray, 1985   nadroparinunfractionated heparingeneral surgerysuggesting
EFS, 1988   nadroparinunfractionated heparinabdominal surgerysuggesting
Dahan, 1989   nadroparinunfractionated heparinthoracic surgerynegative
Barbui, 1990   nadroparinunfractionated heparingeneral surgery -
Eurin, 1994   nadroparinunfractionated heparinabdominal surgery -
reviparin  
Kakkar, 1993   reviparinunfractionated heparingeneral surgery -
tinzaparin  
Bergqvist [42]   tinzaparinplacebonegative
Lassen, 1991   tinzaparinplacebohip surgeryLow risk of bias suggesting-32%
Leizorovicz, 1991   tinzaparinunfractionated heparinabdominal surgery -
UFH  
Cerrato, 1978   UFHno treatmentsuggesting

mechanical devices for thromboprophylaxis  

not classified  
Schirai, 1985   GCS???suggesting-71%
HAAS I, 1990   IPCaspirinsuggesting-53%
HAAS II, 1990   IPCaspirinnegative-32%
McKenna (vs aspirin), 1980   IPCaspirinnegative-74%
Soderdahl, 1997     thigh Length IPCDcalf Length IPCDRisk of bias negative-100%
Scurr, 1981     Footpump (monotherapy)controlsuggesting-60%
Wilson, 1992     Footpump (monotherapy)controlsuggesting-70%
Turpie, 1989     IPC + GCScontrolnegative-55%
Blackshear à exclure, 1987   IPC – sequential compressioncontrolExploratory negative
Fisher, 1995   IPC – sequential compressioncontrolRisk of bias negative-51%
Hull II, 1990   IPC – sequential compressioncontrolsuggesting-51%
Knudson, 1994   IPC – sequential compressioncontrolnegative-100%
Kosir, 1996     IPC – sequential compressioncontrolExploratory negative
Turple II, 1979     IPC – sequential compressioncontrolsuggesting-62%
Bachmann, 1976   IPC – single compressioncontrolRisk of bias suggesting-67%
Butson, 1981     IPC – single compressioncontrolnegative-8%
Bynke, 1987   IPC – single compressioncontrolnegative-100%
Clark, 1974     IPC – single compressioncontrolnegative-100%
Clarke-Pearson I, 1984   IPC – single compressioncontrolsuggesting-72%
Clarke-Pearson II, 1984   IPC – single compressioncontrolnegative28%
Coe, 1978   IPC – single compressioncontrolnegative-85%
Gallus, 1983   IPC – single compressioncontrolRisk of bias negative-34%
Hills, 1972   IPC – single compressioncontrolsuggesting-70%
Hull I, 1979   IPC – single compressioncontrolsuggesting-90%
Skillman, 1978   IPC – single compressioncontrolExploratory suggesting-66%
Turpie I, 1977   IPC – single compressioncontrolnegative-41%
Prasad, 1982     IPC – single compressioncontrolnegative0%
Weitz, 1986   IPC – unknown typecontrolExploratory negative-100%
McKenna, 1980   IPCDcontrolExploratory negative20%
Smith (D), 1978   IPC + dextrandextrannegative-14%
Mellbring, 1986   IPCDHE + low dose heparin -
Elliott, 1999     IPC – sequential compressionFootpumpExploratory -
Fordyce, 1992     IPC + GCSGCSsuggesting-74%
Caprini, 1983   IPC + GCSGCSnegative-79%
Turpie, 1989     IPC + GCSGCSnegative5%
Wautrecht, 1996   IPC + GCSGCSnegative-100%
Rokito, 1996     IPC + GCSGCSnegative
Lacut, 2005     IPC + GCSGCSRisk of bias negative-71%
Pambianco, 1995     IPC + GCSGCSnegative31%
Goldhaber, 1995     IPC + GCSGCSnegative-13%
Dickinson, 1998     IPC + GCS +LMWHGCS +LMWHnegative265%
Hansberry, 1991   IPC/FIDGESnegative-30%
Murakami, 2003     CECTIPCExploratory -
Stone, 1996   FootpumpLMWHExploratory -
Warwick, 1998   FootpumpLMWHRisk of bias negative35%
Blanchard, 1999     FootpumpLMWHExploratory - 126%
Warwick à exclure, 2002   IPCLMWH - 43%
Ginzburg, 2003     IPCLMWHExploratory negative484%
Kurtoglu, 2004     IPCLMWHExploratory negative
Norgren, 1998   IPC + GCSLMWHnegative∞%
*Scurr, 1977   GCSno prophylaxissuggesting-69%
Holford, 1976   GCSno prophylaxissuggesting-53%
Turner, 1984   GCSno prophylaxisnegative-100%
Turpie (GCS vs crtl), 1989   GCSno prophylaxisnegative-56%
Allan, 1983   GCSno prophylaxissuggesting-57%
*Tsapogas, 1971   GCSno prophylaxis -
Barnes, 1978     GCSno prophylaxisnegative∞%
*Ohlund, 1983   GCSno prophylaxis -
*Wille-Jorgensen, 1989     GCSno prophylaxis -
*Inada, 1983   GCSno prophylaxis -
CLOTS, 2009     GCSno prophylaxisRisk of bias negative-8%
Rosengarten, 1970   GCSno prophylaxisnegative0%
Turpie (IPD or GCS), 1989   IPD or GCSno prophylaxisnegative-55%
Clarke Pearson, 1993   IPCUFHnegative-47%
Coe (vs UFH), 1978   IPCUFHnegative-84%
Kosir, 1998     IPCUFHnegative0%
Hansberry (vs UFH), 1991   IPCUFHnegative4%
Niolaides, 1983   IPC + GCSUFHnegative-57%
Santori, 1994     IPC + GCSUFHsuggesting-62%
Stannard (vs UFH+asp), 1996   Footpump (adjunctive therapy)UFH then aspirinExploratory negative-100%
Chandhoke, 1992   IPCvitamin K antagonistsnegative∞%
paiement, 1987   IPCvitamin K antagonistsnegative0%
Kaempffe, 1991   IPCvitamin K antagonistsnegative0%
Muir, 2000     GCS + aspaspirinnegative-51%
Kierkegaard, 1993     GCS + aspaspirinnegative-100%
*Bergqvist, 1984   GCS + dextrandextrannegative-100%
Fredin, 1989   GCS + dextrandextrannegative-35%
Scurr (GCS+IPC vs IPC), 1987   GCS +IPCIPCnegative-86%
Mellbring, 1986   GCS +IPCIPCnegative17%
Camporese, 2008   GCSLMWHnegative 193%
Kalodiki (GCS+LMWH vs LMWH), 1996   GCS + LMWHLMWHnegative-35%
Porteous, 1989   Knee length GCSThigh length GCS -
Williams, 1988   Knee length GCSThigh length GCS -
Hui THR, 1996     Knee length GCSThigh length GCS -
Hui TKR, 1996     Knee length GCSThigh length GCS -
Howard, 2004     Knee length GCSThigh length GCS -
William, 1996   Knee length GCSThigh length GCS -
Rasmussen (GCS vs UFH), 1998   GCSUFHnegative1%
Fasting, 1985   GCSUFHnegative-6%
Hansberry (vs UFH), 1991   GCSUFHnegative150%
aspirin  
Lieberman (A), 1994   IPC + aspirinaspirinnegative-19%
Hull (+asp), 1979   IPC + aspirinaspirinnegative-73%
Hull 2 (+asp), 1979   IPC + aspirinaspirin -
Gelfer, 2006   CECT + aspirinLMWH -
UFH  
Killewich, 1997     IPC + UFHcontrolnegative-60%
Siragusa (H), 1994   IPC + UFHUFHnegative-40%
Ramos, 1996     IPC + UFHUFHsuggesting
Wille-Jorgensen, 1991   GCS + UFHUFHsuggesting-83%
Wille-Jorgensen, 1985   GCS + UFHUFHsuggesting-81%
*Rasmussen (adj), 1988   GCS + UFHUFHnegative-12%
Torngren, 1980   GCS + UFHUFHsuggesting-67%

pentasaccharide  

not classified  
DRIVE, 2008    NCTSR123781Aenoxaparinhip surgeryLow risk of bias -
PENTHIFRA–PLUS (Eriksson), 2003     extended prophylaxisstandard prophylaxiship surgeryLow risk of bias -
fondaparinux  
DRI4757   fondaparinuxplaceboknee surgeryLow risk of bias -
ARTEMIS (Cohen), 2006     fondaparinuxplacebomedical patientsLow risk of bias negative
APOLLO (Turpie), 2007     fondaparinuxplacebo (on top intermittent pneumatic comp.)abdominal surgeryLow risk of bias suggesting -69%
PEGASUS, 2005     fondaparinuxenoxaparinabdominal surgeryLow risk of bias negative-28%∞%
PENTAMAKS (Bauer), 2001     fondaparinuxenoxaparinknee surgeryLow risk of bias suggesting -54%-75%
PENTHIFRA (Eriksson), 2001     fondaparinuxenoxaparinhip surgeryLow risk of bias suggesting-58%1%
PENTATHLON (Turpie), 2002     fondaparinuxenoxaparinhip surgeryLow risk of bias suggesting -31%∞%
EPHESUS (Lassen), 2002     fondaparinuxenoxaparinhip surgeryLow risk of bias suggesting-56%-34%
Turpie, 2001     fondaparinuxenoxaparinhip surgeryLow risk of bias -
L8541   fondaparinuxenoxaparinorthopaedic surgeryLow risk of bias negative-75%
L8635   fondaparinuxenoxaparinknee surgeryExploratory negative

UFH  

enoxaparin  
LeGagneux , 1987   enoxaparinplacebonegative
UFH  
Kettunen, 1974   UFHno treatment -
Caloghera, 1984   UFHno treatment -
Marchelli, 1983   UFHno treatment -
Ziemski, 1979   UFHno treatment -
Morris, 1974     UFHno treatmentsuggesting-81%
Welin-Berger, 1982   UFHno treatmentnegative33%
Bergqvist , 1979   UFHno treatmentsuggesting-29%38%
Gallus , 1973   UFHno treatmentnegative-63%
VTCSG, 1975   UFHno treatmentnegative
Mannucci , 1976   UFHno treatmentsuggesting-69%
Dechavanne, 1974   UFHno treatmentsuggesting-85%∞%
Dechavanne, 1975   UFHno treatmentsuggesting-87%
Bergqvist, 1979   UFHno treatmentsuggesting-35%
Galasko , 1976   UFHno treatmentsuggesting-64%
Gallus , 1973   UFHno treatmentsuggesting-73%
Morris , 1977   UFHno treatmentnegative-25%
Coe, 1978   UFHno treatment -
Sebeseri, 1975   UFHno treatment -
Allen, 1978   UFHno treatment -
Kakkar (IMT)     UFHno treatment -
Gruber     UFHno treatment -
Gordon-Smith, 1972   UFHno treatment -
Nicolaides, 1972     UFHno treatment -
Multiunit, 1974   UFHno treatment -
Abernethy, 1974   UFHno treatment -
Clarke-Pearson, 1983   UFHno treatment -
Plante, 1979     UFHno treatment -
Abraham-Inpijn, 1979   UFHno treatment -
Spebar, 1981   UFHno treatment -
Sagar, 1974     UFHno treatment -
Koppenhagen, 1982   UFHno treatment -
Bergqvist, 1980   UFHno treatment -
Gallus, 1973   UFHno treatment -
Gallus, 1976   UFHno treatment -
Groote Schuur, 1979   UFHno treatment -
Kraytman, 1976   UFHno treatment -
Kraytman, 1977   UFHno treatment -
Kakkar, 1972     UFHplacebo -
Kiil, 1978     UFHplacebo -
Torngren, 1978   UFHplacebo -
Torngren   UFHplacebo -
Lahnborg, 1975   UFHplacebo -
Lahnborg, 1976     UFHplacebo -
Covey, 1975   UFHplacebo -
Belch, 1980   UFHplacebo -
Taberner, 1978   UFHplacebo -
Strand, 1975   UFHplacebo -
Roberts, 1975   UFHplacebo -
Ribaudo, 1975   UFHplacebo -
Wu, 1977   UFHplacebo -
Lawrence, 1977   UFHplacebo -
Muiticentre, 1984   UFHplacebo -
Jourdan, 1984   UFHplacebo -
Torngren, 1978   UFHplacebo -
Kruse-Blinkenberg, 1980   UFHplacebo -
Kraytman, 1977   UFHplacebo -
Marchetti, 1982   UFHplacebo -
Williams , 1978   UFHplacebonegative 280%
Abraham-Inpijn , 1975   UFHplacebonegative-78%-100%
Lowe , 1981     UFHplacebosuggesting-58%-62%
Hampson, 1974     UFHplacebonegative-35%
Moskovitz, 1978   UFHplacebosuggesting-62%174%
Lahnborg, 1980   UFHplacebosuggesting-47%∞%
Xabregas , 1977   UFHplacebonegative-100%
Moskovitz, 1978   UFHplacebonegative-1%∞%
Svend-Hansen, 1981   UFHplacebosuggesting-46%
Bejjani, 1983   UFHplacebo -
Hedlund, 1979   UFHplacebo -
Kutnowski, 1977   UFHplacebo -
Vandendris, 1980   UFHplacebo -
Loew, 1977   UFHaspirin -
Vinazzer, 1980   UFHaspirin -
Muiticentre 53,S4, 1984   UFHDHE -
Muiticentre, 1984   UFHDHE -
van Geloven, 1977   UFHoral anticoagulant -