post stroke

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultstroke (fatal and non fatal) All cause death

anti hypertensive agents  

telmisartan  
PROFESS, 2008   telmisartanplacebo -

anticoagulant  

not classified  
Baker, 1964   anticoagulantno anticoagulantnegative
Bradshaw, 1975   anticoagulantno anticoagulantnegative
LHSPS, 1999   anticoagulantno anticoagulantnegative
VA Study, 1961   anticoagulantno anticoagulantnegative
Wallace, 1964   anticoagulantno anticoagulantsuggesting
McDevitt, 1959     anticoagulantplacebonegative
dicoumarol  
Howard, 1963   dicoumarolplacebonegative
Nat-Coop, 1962   dicoumarolplacebosuggesting
phenindione  
Enger, 1965   phenindioneplacebonegative
Thygesen, 1964   phenindioneplacebonegative
rivaroxaban  
NAVIGATE ESUS, 2018      NCTrivaroxabanaspirin -
warfarin  
SWAT, 1998   warfarinaspirinnegative

antiplatelets drug  

aspirin  
Canadian study (CCSG), 1978   aspirinplaceboLow risk of bias negative-21%
Swedish study , 1987   aspirinplacebonegative22%-8%
UK-TIA low dose , 1988   aspirinplacebonegative-23%-10%
UK-TIA high dose , 1988   aspirinplacebosuggesting-24%-8%
SALT , 1991   aspirinplacebonegative-24%-11%
Reuther , 1976   aspirinplacebonegative0%-100%
AITA, 1975   aspirinplacebonegative-42%-39%
DCS, 1980   aspirinplacebonegative18%11%
AICLA, 1981   aspirinplacebonegative-34%9%
Lindblad , 1991   aspirinplacebosuggesting-39%-61%
Danish low-dose, 1986   aspirinplacebonegative-33%41%
ESPS 2 , 1996   aspirinplacebosuggesting-18%-10%

cholesterol lowering intervention  

atorvastatin  
SPARCL, 2006      NCTatorvastatinplacebopost stroke cerebral vascular disease Low risk of bias suggesting-15%2%
simvastatin  
HPS (post troke sub group), 2004     simvastatinplacebopost stroke cerebral vascular disease Low risk of bias suggesting-1%

foramen ovale closure  

not classified  
CLOSURE I, 2010      NCTStarflexmedical treatmentRisk of bias negative

prevention  

folic acid  
VITATOPS, 2010    NCTfolic acid, vit B12 and vit B6placeboLow risk of bias suggesting
VISP (Toole), 2004   high dose - folic acid, vit B12 and vit B6low dose - folic acid, vit B12 and vit B6Low risk of bias negative4%-14%