antiplatelets drug

systematic review meta-analysis network meta-analysis

Select acute coronary syndromeacute myocardial infarctionCABG surgerycardiovascular preventiondiabetes type 2hypertensionpercutaneous coronary interventionperipheral vascular diseasespost myocardial infarctionpost strokethrombosis prevention ACS (excluding AMI)All type of patientuncoded clinical condition ***Diabetic patientsgeneral surgerymedical patientsorthopedic surgerypatients with scheduled percutaneous coronary interventionpatients without cardiovascular diseaseprimary preventionsecondary prevention in patients with CADsecondary preventionsecondary prevention in patients with intermittent claudication       6 months DAPTantiplatelet drugsaspirinclopidogreldipyridamoldual antiplatelet therapyP2Y12 receptor antagonistP2Y12 receptor-antagonistPAR-1 inhibitorplatelet aggregation inhibitorsprolonged dual antiplatelet therapyselective PAR-1 thrombin receptor antagonistthienopyridineticlopidinetriple antiplateletunfractionated heparin variousaspirinatopaxarcangrelorcilostazolclopidogreldipyridamolelinogrelketanserinepicotamideprasugrelsulfinpyrazonesuloctidilsulotrobanticagrelorticlopidinetrapidiltriflusalUFHvorapaxar vs placebo or controlvs placebo or no treatmentvs anticoagulant + antiplateletvs antiplatelet drugsvs aspirinvs clopidogrelvs short antiplatelet drugvs standard clopidogrel      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	Non fatal MI (212)cardiovascular events (196)All cause death (193)Cardiovascular death (166)Deep vein thrombosis (144)fatal pulmonary embolism (142)Non fatal stroke (139)non-fatal pulmonary embolism (131)Major bleeding (130)Vascular death (94)myocardial infarction (fatal and non fatal) (93)stroke (fatal and non fatal) (92)Bleeding (78)Fatal bleeding (71)non pulmonary embolism death (65)Non vascular death (53)Vascular events (46)Coronary event (45)Fatal MI (45)Fatal stroke (40)Coronary death (35)wound haematoma / infection (33)Non cerebral major bleeding (30)non cardiovascular death (30)MACE (22)Haemmorhagic stroke (19)Major gastrointestinal bleeding (19)ischemic stroke (17)proximal DVT (17)fatal bleeding (16)intracranial hemorrhage (14)cardiovascular death, MI, stroke (13)Peripheral vascular events (11)stable angina (11)Gastrointestinal Bleeding (10)Revascularization (8)Amputation (8)stent thrombosis (8)all cause death, MI, stroke (7)Peptic ulcer (6)refractory ischemia (4)fatal hemorrhagic stroke (4)unstable angina (4)non fatal hemorrhagic stroke (3)Hematuria (3)major bleeding TIMI (2)death, MI, unplanned revascularization (2)Stent thrombosis (any, end of follow up) (2)Major or minor TIMI bleeding (2)Urgent target-vessel revascularization (2)target lesion revascularisation (1)Cardiovascular death/MI/stent thrombosis (1)GUSTO severe/moderate bleeding (1)any bleedings (1)net benefit (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	Non fatal MI	cardiovascular events
acute coronary syndrome
aspirin
ATACS-pilot, 1990	aspirin	control				negative
Huddinge, 1988	aspirin	control				negative
Frankfurt, 1976	aspirin	control				negative
VA-pilot	aspirin	placebo				negative
VA-main, 1983	aspirin	placebo			Low risk of bias	suggesting
RISC, 1990	aspirin	placebo			Low risk of bias	suggesting
ALDUSA-pilot	aspirin	placebo				negative
Théroux, 1988	aspirin	placebo			Low risk of bias	suggesting
Canadian (Aspirin vs PBO), 1985	aspirin	placebo			Low risk of bias	-
Dutch-aspirin, 1990	aspirin	placebo			Low risk of bias	negative
ISIS-pilot, 1987	aspirin	placebo			Low risk of bias	negative
ISIS-2, 1988	aspirin	placebo			Low risk of bias	suggesting
APRICOT, 1993	aspirin	placebo			Low risk of bias	suggesting
Canadian (Aspirin + sulfinpyrazone), 1985	aspirin + sulfinpyrazone	placebo			Low risk of bias	negative
atopaxar
J-LANCELOT, 2010	atopaxar	placebo			Exploratory	-
LANCELOT ACS	atopaxar	placebo			Exploratory	-
clopidogrel
COMMIT, 2005      NCT	clopidogrel	placebo			Low risk of bias	suggesting
CLARITY-TIMI 28, 2005	clopidogrel	placebo			Low risk of bias	-
CURE, 2001	clopidogrel + aspirin	aspirin			Low risk of bias	suggesting
CURRENT OASIS 7 (clopidogrel), 2010    NCT	clopidogrel high-dose regimen	clopidogrel standard-dose			Low risk of bias	negative
dipyridamol
Prandoni, 1991	aspirin + dipyridamol	placebo			Low risk of bias	negative
elinogrel
ERASE-MI, 2009	elinogrel	placebo			Low risk of bias	negative
prasugrel
TRILOGY ACS (overall population), 2012        NCT	prasugrel	clopidogrel			Low risk of bias	negative
TRITON-TIMI 38, 2007      NCT	prasugrel	clopidogrel			Low risk of bias	suggesting
sulfinpyrazone
Dutch sulphinpyrazone, 1986	sulfinpyrazone	control				negative
Canadian (sulfinpyrazone alone), 1985	sulfinpyrazone	placebo			Low risk of bias	-
Wilcox, 1980	sulfinpyrazone	placebo				negative
Louvain sulphinpyrazone, 1983	sulfinpyrazone	placebo			Low risk of bias	negative
ticagrelor
PLATO, 2009      NCT	ticagrelor	clopidogrel			Low risk of bias	suggesting
DISPERSE-2 (90mg), 2007	ticagrelor	clopidogrel			Low risk of bias	negative
ticlopidine
STAI, 1990	ticlopidine	control				suggesting
Knudsen-A, 1985	ticlopidine	control				negative
Florida UA	ticlopidine	placebo				negative
trapidil
Modena	trapidil	placebo				suggesting
triflusal
Plaza, 1993	triflusal	placebo			Low risk of bias	suggesting
vorapaxar
TRACER, 2011      NCT	vorapaxar	placebo (on top standard therapy)			Low risk of bias	-
acute myocardial infarction
aspirin
Huddinge, 1988	aspirin	control				negative
Frankfurt, 1976	aspirin	control				negative
Dutch-aspirin, 1990	aspirin	placebo			Low risk of bias	negative
ISIS-pilot, 1987	aspirin	placebo			Low risk of bias	negative
ISIS-2, 1988	aspirin	placebo			Low risk of bias	suggesting
APRICOT, 1993	aspirin	placebo			Low risk of bias	suggesting
clopidogrel
COMMIT, 2005      NCT	clopidogrel	placebo			Low risk of bias	suggesting
CLARITY-TIMI 28, 2005	clopidogrel	placebo			Low risk of bias	-
elinogrel
ERASE-MI, 2009	elinogrel	placebo			Low risk of bias	negative
sulfinpyrazone
Dutch sulphinpyrazone, 1986	sulfinpyrazone	control				negative
Wilcox, 1980	sulfinpyrazone	placebo				negative
Louvain sulphinpyrazone, 1983	sulfinpyrazone	placebo			Low risk of bias	negative
ticlopidine
Knudsen-A, 1985	ticlopidine	control				negative
CABG surgery
aspirin
McEnany, 1982	aspirin	placebo			Low risk of bias	negative
Lorenz, 1984	aspirin	placebo			Low risk of bias	negative
GESIC (aspirin), 1990	aspirin	placebo			Low risk of bias	negative
Sydney, 1991	aspirin	placebo			Low risk of bias	-
Hockings, 1993	aspirin	placebo			Low risk of bias	-
clopidogrel
CASCADE, 2009      NCT	clopidogrel+aspirin	aspirin			Low risk of bias	-
dipyridamol
Pantely, 1979	aspirin + dipyridamol	control				negative
Brussels, 1987	aspirin + dipyridamol	control				negative
Czech, 1986	aspirin + dipyridamol	control				-
Des Moines, 1980	aspirin + dipyridamol	control				-
Toronto dipyridamole, 1987	dipyridamol	control				-
Brooks, 1985	aspirin + dipyridamol	placebo			Low risk of bias	negative
Mayo-A, 1984	aspirin + dipyridamol	placebo			Low risk of bias	negative
Wadsworth, 1985	aspirin + dipyridamol	placebo			Low risk of bias	negative
Basel, 1989	aspirin + dipyridamol	placebo			Low risk of bias	negative
Leeds-B, 1985	aspirin + dipyridamol	placebo			Low risk of bias	-
Thaulow, 1987	aspirin + dipyridamol	placebo			Low risk of bias	-
GESIC (aspirin+dipyridamol), 1990	aspirin + dipyridamol	placebo			Low risk of bias	negative
Ekestrom, 1990	dipyridamol	placebo			Low risk of bias	-
sulfinpyrazone
Baur, 1982	sulfinpyrazone	placebo			Low risk of bias	-
sulotroban
German sulotroban, 1989	sulotroban	control				-
ticlopidine
Zurich, 1982	ticlopidine	control				-
Knudsen-B, 1983	ticlopidine	control				-
Romeo, 1983	ticlopidine	control				-
Kohn, 1990	ticlopidine	control				-
Liège-I, 1984	ticlopidine	placebo			Low risk of bias	negative
Liège-II, 1987	ticlopidine	placebo			Low risk of bias	negative
cardiovascular prevention
aspirin
JPAD, 2008      NCT	aspirin	no treatment			Risk of bias	suggesting
PPP (diabetics sub group), 2003	aspirin	no treatment			Exploratory	negative
British Doctor’s Trial, 1988	aspirin	no treatment	primary prevention		Risk of bias	negative
Primary Prevention Project, 2001	aspirin	no treatment	primary prevention		Risk of bias	negative
POPADAD aspirin, 2008	aspirin	placebo			Low risk of bias	negative
DAMAD, 1989	aspirin	placebo			Low risk of bias	negative
ETDRS, 1992	aspirin	placebo			Low risk of bias	suggesting
PHS (diabetics sub group), 1989	aspirin	placebo			Low risk of bias	suggesting
WHS (diabetics sub group), 2005	aspirin	placebo			Low risk of bias	suggesting
Physicians Health Study, 1989    NCT	aspirin	placebo	primary prevention		Low risk of bias	suggesting
Thrombosis Prevention Trial, 1998        NCT	aspirin	placebo	primary prevention		Low risk of bias	suggesting
HOT, 1998	aspirin	placebo	primary prevention		Low risk of bias	suggesting
Women’s Health Study, 2005	aspirin	placebo	primary prevention		Low risk of bias	suggesting
AAA, 2009	aspirin	placebo	secondary prevention		Low risk of bias	negative
ASPREE, 2018    NCT	aspirin	placebo				-
ASCEND, 2018      NCT	aspirin	placebo				suggesting
Schoop, 1983	aspirin	placebo			Low risk of bias	-
Hess, 1985	aspirin	placebo				-
Munich A, 1975	aspirin	placebo			Low risk of bias	-
Munich B, 1975	aspirin	placebo			Low risk of bias	-
CLIPS, 2007	aspirin	placebo			Low risk of bias	suggesting
CDPA, 1976	aspirin	placebo			Low risk of bias	negative
Cardiff I, 1974	aspirin	placebo			Low risk of bias	negative
Cardiff II, 1979	aspirin	placebo			Low risk of bias	negative
Vogel, 1979	aspirin	placebo			Low risk of bias	suggesting
AMIS, 1980    NCT	aspirin	placebo			Low risk of bias	suggesting
GAMIS, 1980	aspirin	placebo			Low risk of bias	negative
PARIS, 1980	aspirin	placebo			Low risk of bias	negative
JAMIS, 1999	aspirin	placebo				suggesting
SAPAT, 1992	aspirin	placebo			Low risk of bias	suggesting
clopidogrel
CAPRIE, 1996	clopidogrel	aspirin	secondary prevention		Low risk of bias	suggesting
CAPRIE (PAD subgroup), 1996	clopidogrel	aspirin			Low risk of bias	suggesting
ASCET    NCT	clopidogrel	aspirin			Risk of bias	negative
CHARISMA, 2006      NCT	clopidogrel	placebo (on top aspirin)	secondary prevention		Low risk of bias	suggesting
dipyridamol
Atlanta (Sbar), 1967	dipyridamol	control			Low risk of bias	negative
Becker, 1967	dipyridamol	control			Low risk of bias	negative
Wirecki, 1967	dipyridamol	control			Low risk of bias	negative
Hess (2), 1985	aspirin + dipyridamol	placebo			Low risk of bias	-
Schoop (2), 1983	aspirin + dipyridamol	placebo			Low risk of bias	-
VA study, 1986	aspirin + dipyridamol	placebo			Low risk of bias	-
Igloe, 1970	dipyridamol	placebo			Low risk of bias	-
Zion, 1961	dipyridamol	placebo			Low risk of bias	-
Kinsella, 1962	dipyridamol	placebo			Low risk of bias	-
Leiberman, 1964	dipyridamol	placebo			Low risk of bias	-
Dewar, 1961	dipyridamol	placebo			Low risk of bias	-
Neumann, 1964	dipyridamol	placebo			Low risk of bias	-
Foulds, 1960	dipyridamol	placebo			Low risk of bias	-
PARIS, 1980	dipyridamol + aspirin	placebo			Low risk of bias	negative
PARIS-II, 1986	dipyridamol + aspirin	placebo			Low risk of bias	negative
PARIS, 1980	dipyridamol + aspirin	aspirin			Low risk of bias	negative
ketanserine
PACK, 1996	ketanserine	placebo			Low risk of bias	-
Walden, 1991	ketanserine	placebo			Low risk of bias	-
Thulesius, 1987	ketanserine	placebo			Low risk of bias	-
picotamide
Cocozza, 1995	picotamide	placebo			Low risk of bias	negative
ADEP, 1993	picotamide	placebo			Low risk of bias	-
Neirotti, 1994	picotamide	placebo			Low risk of bias	-
Coto, 1989	picotamide	placebo			Low risk of bias	-
sulfinpyrazone
Dutch, 1980	sulfinyrazone	placebo				negative
suloctidil
Adriaensen, 1976	suloctidil	placebo			Low risk of bias	-
Verhaeghe, 1981	suloctidil	placebo			Low risk of bias	-
Jones, 1982	suloctidil	placebo			Low risk of bias	-
Holm, 1984	suloctidil	placebo			Low risk of bias	-
ticagrelor
EUCLID, 2016        NCT	ticagrelor	clopidogrel			Low risk of bias	-
PEGASUS 60mg, 2015        NCT	ticagrelor	placebo (on top aspirin)	secondary prevention		Low risk of bias	suggesting
PEGASUS 90mg, 2015        NCT	ticagrelor	placebo (on top aspirin)	secondary prevention		Low risk of bias	suggesting