thrombosis prevention

systematic review meta-analysis network meta-analysis

Select graduated compression stockingsmechanical devices for thromboprophylaxisanticoagulantantiplatelets drugantithromboticsdirect antithrombinsdirect factor Xa inhibitorsdirect oral anticoagulant (DAO)heparin (UFH or LMWH)LMWHpentasaccharideUFH abdominal surgeryAll type of patientall type of surgeryarthroscopyelective hip replacementelective major knee surgerygeneral surgerygynaecological surgeryhip Fracturemedical patientsneurosurgeryorthopaedic surgeryorthopedic surgeryuncoded clinical condition ***urologic surgery       antivitamins Kdirect factor Xa inhibitorsextended prophylaxisExtended-duration prophylaxisFootpump as adjunctive therapyFootpump monotherapyGCS (adjunctive therapy)Graduated compression stockings IPCIPC adjunctive therapyIPC monotherapyLMWHLow molecular weight heparinmechanicalNOACoral direct thrombin inhibitorplatelet aggregation inhibitorsrecombinant hirudinsynthetic oligosaccharideUFHunfractionated heparin candesartanLMWHacenocoumarolapixabanardeparinaspirinbetrixaban CertoparindabigatrandalteparindeltaparindipyridamoledoxabanenoxaparinfondaparinuxfraxiparinnadroparinphenindionereviparinrivaroxabansuloctidilticlopidinetinzaparinUFHwarfarinximelagatran vs controlvs control or placebovs LMWHvs pentascharidevs placebo or controlvs placebo or no treatmentvs antiplatelet drugsvs aspirinvs Danaparoidvs Dextranvs DHEvs fondaparinuxvs GCSvs heparinvs intermittent pneumatic compressionvs IPCvs Low molecular weight heparinvs oral anticoagulantvs UFHvs Unfractionated heparin      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	Deep vein thrombosis (711)non-fatal pulmonary embolism (476)Major bleeding (462)Bleeding (436)fatal pulmonary embolism (429)All cause death (310)asymptomatic DVT (263)Symptomatic pulmonary embolism (256)wound haematoma / infection (243)Fatal bleeding (203)Symptomatic venous thromboembolism (DVT, PE) (189)proximal DVT (173)total VTE and all-cause mortality (123)Symptomatic deep-vein thrombosis (107)transfusion (107)non pulmonary embolism death (104)distal DVT (98)major VTE (fatal and non fatal DVT,PE) (98)pulmonary embolism (symptomatic and asymptomatic) (77)major or clinically relevant non-major bleeding (75)Coronary event (75)Venous thromboembolism (64)myocardial infarction (fatal and non fatal) (33)Minor bleeding (14)Venous thromboembolism or death (8)any bleedings (7)proximal deep-vein thrombosis (6)net benefit (2) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	Deep vein thrombosis	non-fatal pulmonary embolism
anticoagulant
not classified
Borsgtrom, 1965		no treatment				-
acenocoumarol
Hamulyak, 1994	Acenocoumarol	Nadroparin				negative
Samama, 2001	Acenocoumarol	Reviparin				negative
van Geloven, 1977	Acenocoumarol	unfractionated heparin			Low risk of bias	-
apixaban
ADVANCE 3, 2010    NCT	apixaban	enoxaparin	hip surgery		Low risk of bias	suggesting
ADVANCE 2, 2010      NCT	apixaban	enoxaparin (europe regimen)	knee surgery		Low risk of bias	suggesting
APROPOS 2.5mg, 2007    NCT	apixaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
ADVANCE-1, 2008      NCT	apixaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	suggesting
dabigatran
RE-NOVATE (150mg), 2007      NCT	dabigatran 150mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-NOVATE (220mg), 2007      NCT	dabigatran 220mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-NOVATE 2    NCT	dabigatran 220mg	enoxaparin	hip surgery		Low risk of bias	negative
RE-MODEL (150mg), 2007	dabigatran 150mg	enoxaparin (europe regimen)	knee surgery		Low risk of bias	negative
RE-MODEL (220mg), 2007	dabigatran 220mg	enoxaparin (europe regimen)	knee surgery		Low risk of bias	negative
RE-MOBILIZE (150mg), 2008	dabigatran 150mg	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
RE-MOBILIZE (220mg), 2008	dabigatran 220mg	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
edoxaban
STARS J-V    NCT	edoxaban	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
phenindione
Eskeland, 1966	Phenindione	no treatment				-
Hamilton, 1970	Phenindione	no treatment				-
rivaroxaban
RECORD 1, 2008      NCT	rivaroxaban	enoxaparin	hip surgery		Low risk of bias	suggesting
RECORD 3, 2008    NCT	rivaroxaban	enoxaparin (europe regimen)	knee surgery		Low risk of bias	suggesting
ODIXa-HIP 10mg, 2006	rivaroxaban	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
RECORD 2, 2008    NCT	rivaroxaban (long duration)	enoxaparin (short duration)	hip surgery		Low risk of bias	suggesting
ODIXa-KNEE, 2005	rivaroxaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	negative
RECORD 4, 2009    NCT	rivaroxaban	enoxaparin (US regimen)	knee surgery		Low risk of bias	suggesting
warfarin
Pinto, 1970	Warfarin	no treatment				-
Hume, 1973	Warfarin	no treatment				-
Morris, 1976	Warfarin	no treatment				-
Powers, 1989	Warfarin	no treatment				-
Myrhe, 1969	Warfarin	placebo			Low risk of bias	-
RD Heparin, 1994	Warfarin	Ardeparin				suggesting
Heit, 1997	Warfarin	Ardeparin			Low risk of bias	suggesting
Powers, 1989	Warfarin	Aspirin				-
Lotke, 1997	Warfarin	Aspirin				-
Francis, 1997	Warfarin	Dalteparin				suggesting
Hull, 2000	Warfarin	Dalteparin			Low risk of bias	suggesting
Gerhart, 1991	Warfarin	Danaparoid				-
van Comp, 1998	Warfarin	Danaparoid				-
Myrhe, 1969	Warfarin	Dextran			Low risk of bias	-
Harris, 1972	Warfarin	Dextran				-
Barber, 1977	Warfarin	Dextran				-
Francis, 1983	Warfarin	Dextran				-
Leclerc, 1996	Warfarin	Enoxaparin			Low risk of bias	suggesting
Colwell, 1999	Warfarin	Enoxaparin				suggesting
Fitzgerald, 2001	Warfarin	Enoxaparin				suggesting
Paiement, 1987	Warfarin	Intermittent pneumatic compression				-
Bailey, 1991	Warfarin	Intermittent pneumatic compression				-
Kaempffe, 1991	Warfarin	Intermittent pneumatic compression				-
Francis, 1992	Warfarin	Intermittent pneumatic compression				-
Hull, 1993	Warfarin	Logiparin			Low risk of bias	suggesting
Hume, 1973	Warfarin	Sudoxicam				-
Hume, 1973	Warfarin	unfractionated heparin				-
Barber, 1977	Warfarin	unfractionated heparin				-
antiplatelets drug
not classified
Veth, 1985	sp	control			Risk of bias	-
Mocris-C , 1977	Flurbiprofen	no treatment			Exploratory	negative
Massachusetts-I , 1981	Hydroxychloroquine	no treatment			Exploratory	negative
Denver-Il , 1980	dipyridamol + ASA	placebo			Low risk of bias	negative
Carter IA, 1971	hydroxychloroquine	placebo			Low risk of bias	-
Carter IB, 1971	hydroxychloroquine	placebo			Low risk of bias	-
Carter II, 1974	hydroxychloroquine	placebo			Low risk of bias	-
New York, 1977	hydroxychloroquine	placebo			Low risk of bias	-
Vermont, 1975	hydroxychloroquine	placebo			Low risk of bias	-
Massachusetts-II, 1976	Hydroxychloroquine	placebo			Exploratory	suggesting
Cooke, 1977	Hydroxychloroquine	placebo			Exploratory	negative
Hume-A, 1977	Hydroxychloroquine	placebo			Exploratory	negative
Stockholm-II, 1981	Hydroxychloroquine	placebo			Exploratory	negative
Danish-A , 1976	Hydroxychloroquine	placebo			Exploratory	negative
Danish-B , 1976	Hydroxychloroquine	placebo			Exploratory	suggesting
Wood , 1973	RA233	placebo			Exploratory	negative
Athens, 1981	sp	placebo			Low risk of bias	-
aspirin
Clagett, 1975	aspirin	control			Risk of bias	-
Zekert VI, 1982	aspirin	control			Risk of bias	-
Pasteyer, 1977	Aspirin	no treatment			Exploratory	negative
Rocha, 1986	Aspirin	no treatment			Exploratory	suggesting
Stockholm-I, 1975	Aspirin	placebo			Exploratory	negative
Harris-I, 1977	Aspirin	placebo			Low risk of bias	suggesting
McKenna-I, 1980	Aspirin	placebo			Exploratory	suggesting
Sautter, 1983	Aspirin	placebo			Exploratory	suggesting
McBride, 1983	Aspirin	placebo			Exploratory	negative
Zekert-I , 1974	Aspirin	placebo			Exploratory	suggesting
Powers , 1976	Aspirin	placebo			Exploratory	suggesting
Erfurt-B , 1979	Aspirin	placebo			Exploratory	negative
PEP hip-fracture, 2000	aspirin	placebo			Low risk of bias	suggesting
MRC, 1972	aspirin	placebo			Low risk of bias	negative
Loew DVT, 1974	aspirin	placebo			Low risk of bias	-
Erfurt-A, 1979	aspirin	placebo			Low risk of bias	-
Zekert V, 1980	aspirin	placebo			Low risk of bias	-
Vinazzer I, 1980	aspirin	placebo			Low risk of bias	-
Vinazzer II, 1977	aspirin	placebo			Low risk of bias	-
PEP elective arthroplasty, 2000	aspirin	placebo			Low risk of bias	-
dipyridamol
Chicago, 1982	aspirin + dipyridamol	control			Exploratory	negative
Parodi I, 1973	dipyridamol + aspirin	control			Exploratory	suggesting
Parodi II, 1973	dipyridamol + aspirin	control			Risk of bias	-
Zekert-III, 1977	dipyridamol + aspirin	control			Risk of bias	-
Australian I, 1975	dipyridamol + aspirin	control			Risk of bias	-
Australian II, 1976	dipyridamol + aspirin	control			Risk of bias	-
Toulouse I, 1979	dipyridamol + aspirin	control			Risk of bias	-
Harjola DVT, 1982	dipyridamol + aspirin	control			Risk of bias	-
Weiss, 1977	dipyridamol + aspirin	control			Exploratory	-
Lyon-I, 1975	aspirin + dipyridamol	no treatment			Exploratory	suggesting
Morris-B , 1977	aspirin + dipyridamol	no treatment			Exploratory	negative
Morris-A , 1977	dipyridamol	no treatment			Exploratory	negative
Hamburg, 1976	aspirin + dipyridamol	placebo			Exploratory	negative
Encke-II , 1976	aspirin + dipyridamol	placebo			Exploratory	negative
Frankfurt, 1981	aspirin + dipyridamol	placebo			Low risk of bias	negative
Encke IA, 1976	dipyridamol + aspirin	placebo			Low risk of bias	-
Encke IB, 1976	dipyridamol + aspirin	placebo			Low risk of bias	-
suloctidil
Turpie, 1985	Suloctidil	placebo			Low risk of bias	-
ticlopidine
Lasierra, 1982	ticlopidine	placebo			Low risk of bias	-
Walker, 1974	ticlopidine	placebo			Low risk of bias	-
McKenna-II , 1983	ticlopidine	placebo			Low risk of bias	negative
McKenna-II, 1983	Ticlopidine	placebo			Exploratory	negative
Lyon-II	Ticlopidine	placebo			Exploratory	negative
Gardecki	Ticlopidine	placebo			Exploratory	negative
UFH
Morris, 1974	UFH	no treatment				suggesting
Welin-Berger, 1982	UFH	no treatment				negative
Bergqvist , 1979	UFH	no treatment				suggesting
VTCSG, 1975	UFH	no treatment				negative
Mannucci , 1976	UFH	no treatment				suggesting
Dechavanne, 1974	UFH	no treatment				suggesting
Dechavanne, 1975	UFH	no treatment				suggesting
Bergqvist, 1979	UFH	no treatment				suggesting
Galasko , 1976	UFH	no treatment				suggesting
Gallus , 1973	UFH	no treatment				suggesting
Morris , 1977	UFH	no treatment				negative
Williams , 1978	UFH	placebo				negative
Abraham-Inpijn , 1975	UFH	placebo				negative
Hampson, 1974	UFH	placebo				negative
Moskovitz, 1978	UFH	placebo				suggesting
Lahnborg, 1980	UFH	placebo				suggesting
Xabregas , 1977	UFH	placebo				negative
Moskovitz, 1978	UFH	placebo				negative
Svend-Hansen, 1981	UFH	placebo				suggesting
antithrombotics
not classified
Veth, 1985	sp	control			Risk of bias	-
Cohen (L8405), 2007	compression stocking group	control (on top fondaparinux)	hip surgery		Risk of bias	negative
SAVE-HIP1, 2012      NCT	semuloparin	enoxaparin	hip surgery			suggesting
SAVE-KNEE, 2012      NCT	semuloparin	enoxaparin	knee surgery			negative
SAVE-HIP 2, 2012      NCT	semuloparin	enoxaparin	hip surgery			negative
EXCLAIM, 2010      NCT	Extended-duration prophylaxis	error	medical patients		Low risk of bias	suggesting
Borsgtrom, 1965		no treatment				-
Mocris-C , 1977	Flurbiprofen	no treatment			Exploratory	negative
Massachusetts-I , 1981	Hydroxychloroquine	no treatment			Exploratory	negative
Denver-Il , 1980	dipyridamol + ASA	placebo			Low risk of bias	negative
Valle , 1988	fluxum	placebo				negative
Massachusetts-II, 1976	Hydroxychloroquine	placebo			Exploratory	suggesting
Cooke, 1977	Hydroxychloroquine	placebo			Exploratory	negative
Hume-A, 1977	Hydroxychloroquine	placebo			Exploratory	negative
Stockholm-II, 1981	Hydroxychloroquine	placebo			Exploratory	negative
Danish-A , 1976	Hydroxychloroquine	placebo			Exploratory	negative
Danish-B , 1976	Hydroxychloroquine	placebo			Exploratory	suggesting
Carter IA, 1971	hydroxychloroquine	placebo			Low risk of bias	-
Carter IB, 1971	hydroxychloroquine	placebo			Low risk of bias	-
Carter II, 1974	hydroxychloroquine	placebo			Low risk of bias	-
New York, 1977	hydroxychloroquine	placebo			Low risk of bias	-
Vermont, 1975	hydroxychloroquine	placebo			Low risk of bias	-
Dahan, 1986	Pharmuka	placebo	medical patients		Low risk of bias	suggesting
Wood , 1973	RA233	placebo			Exploratory	negative
Athens, 1981	sp	placebo			Low risk of bias	-
Marlovits, 2007	extended-duration thromboprophylaxis	standard-duration thromboprophylaxis			Risk of bias	suggesting
DRIVE, 2008    NCT	SR123781A	enoxaparin	hip surgery		Low risk of bias	-