Enoxaparin LMWH
systematic review meta-analysis network meta-analysis
 

Clexane - Lovenox      

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Trial Studied trt Control trt patientstagsROB Trial resultMajor bleedingAll cause death

acute coronary syndrome  

RESCUE    NCTenoxaparinunfractionated heparin -
EVET, 2005     enoxaparintinzaparinsuggesting-50%
TIMI 11 B (short term), 1998   enoxaparinUFH (on top of aspirin)Low risk of bias suggesting 52%-17%
SYNERGY, 2005          NCTenoxaparinUFH (on top of aspirin)negative 19%4%
ESSENCE, 1997     enoxaparinUFH (on top of aspirin)Low risk of bias suggesting -7%-3%
INTERACT, 2006       enoxaparinUFH (on top of aspirin)suggesting -60%-42%
TIMI 11 B (long term), 1998   enoxaparinUFH (on top of aspirin)Low risk of bias negative 90%-4%

acute myocardial infarction  

AMI-SK, 2002     EnoxaparinplaceboLow risk of bias -
ASSENT 3, 2001     EnoxaparinUFHsuggesting
ASSENT 3 Plus, 2003     EnoxaparinUFHnegative
ENTIRE-TIMI 2, 2002     EnoxaparinUFHsuggesting
Baird, 2002     EnoxaparinUFHnegative
HART II, 2001     EnoxaparinUFHnegative

heart failure  

THE-PRINCE (Kleber), 2003     enoxaparinUFH -

percutaneous coronary intervention  

Drozd, 2001   enoxaparinUFHnegative
Dudek b (enox alone), 2000   enoxaparinUFH -
Dudek, 2000   enoxaparinUFHnegative
STEEPLE, 2006      NCTenoxaparinUFHRisk of bias -
Galeote, 2001   enoxaparinUFHnegative
CRUISE, 2003     enoxaparinUFHExploratory negative
Rabah, 1999     enoxaparinUFHExploratory negative
ATOLL, 2010   enoxaparinUFHRisk of bias -
Dubek b (+abciximal), 2001   enoxaparin+abciximabUFH -

pulmonary embolism  

PREPIC, 1998     Enoxaparinunfractionated heparinRisk of bias negative
Merli sub group, 2001     Enoxaparinunfractionated heparinExploratory negative

superficial thrombophlebitis  

STENOX (enoxaparin 1.5mg/hg), 2003   enoxaparinplacebo -
Stenox (enoxaparin 40mg), 2003     enoxaparinplacebo -

thrombosis prevention  

Canata, 2003   enoxaparincontrolExploratory negative
Warwick, 1995     enoxaparinno treatmenthip surgerynegative
Ho [43]   enoxaparinno treatmentnegative
Samama, 1997     enoxaparinplacebohip surgeryLow risk of bias suggesting
Kalodiki, 1996   enoxaparinplacebohip surgeryLow risk of bias -
MEDENOX, 1999     Enoxaparinplacebomedical patientsLow risk of bias suggesting48%-26%
Lederle, 2006     Enoxaparinplacebomedical patientsLow risk of bias negative-60%
Agnelli, 1998     enoxaparinplacebosuggesting
Melon, 1987   enoxaparinplacebonegative
LIFENOX, 2011      NCTenoxaparinplacebomedical patientsLow risk of bias negative40%0%
LeGagneux , 1987   enoxaparinplacebonegative36%
Turpie, 1986   enoxaparinplacebohip surgeryLow risk of bias suggesting-100%
Leclerc, 1991   enoxaparinplaceboknee surgeryLow risk of bias suggesting
DES Group , 1991   enoxaparinDextranhip surgerysuggesting∞%
Comp, 2001     out of hospital Enoxaparinstandard prophylaxissuggesting-100%-100%
Planes, 1996     out of hospital Enoxaparinstandard prophylaxisnegative
Bergqvist, 1996     out of hospital Enoxaparinstandard prophylaxissuggesting
Bergmann and Neuhart, 1996   enoxaparinUFHmedical patientsLow risk of bias negative-10%
Lechler, 1996   enoxaparinUFHmedical patientsLow risk of bias negative-36%
Kleber, 2003     enoxaparinUFHmedical patientsnegative-40%
Nurmohamed, 1995   enoxaparinunfractionated heparingeneral surgery -
ENOXACAN, 1997   enoxaparinunfractionated heparinabdominal surgery -
Gonzalez, 1996   enoxaparinunfractionated heparinabdominal surgery -
McLeod (Canadian), 1995   enoxaparinunfractionated heparinabdominal surgery -
Gazzaniga (ISG), 1993   enoxaparinunfractionated heparingeneral surgery -
Kaaja, 1992   enoxaparinunfractionated heparingynaecological surgery -
Samama 3, 1988   enoxaparinunfractionated heparingeneral surgerynegative-8%∞%
Samama 2, 1988   enoxaparinunfractionated heparingeneral surgerynegative∞%∞%
Samama 1, 1988   enoxaparinunfractionated heparingeneral surgerynegative-1%∞%
Planes , 1988   enoxaparinUnfractionated heparinhip surgerysuggesting
Levine , 1991   enoxaparinUnfractionated heparinhip surgerynegative

venous thrombosis  

Veiga, 2000     EnoxaparinacenocoumarolRisk of bias negative
González-Fajardo, 2008     EnoxaparincoumarinRisk of bias -
Cesarone, 2003   extended enoxaparinstandard treatmentnegative-33%
Deitcher, 2006     extended enoxaparinstandard treatmentnegative204%1%
Meyer, 2002     extended enoxaparinstandard treatmentnegative-56%-20%
Pini, 1994   EnoxaparinwarfarinRisk of bias negative
Gonzalez-Fajardo, 1999     EnoxaparinwarfarinRisk of bias suggesting
Meyer, 2002     EnoxaparinwarfarinRisk of bias negative
Deitcher, 2003   EnoxaparinwarfarinRisk of bias negative
Merli, 2001     once daily enoxaparintwice daily enoxaparinLow risk of bias negative65%
Merli (once daily vs UFH), 2001   once daily enoxaparinUFHLow risk of bias negative19%
Simonneau et al , 1993   Enoxaparinunfractionated heparinnegative50%



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