Sirolimus eluting stent Drug eluting stent  

CYPHER      

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Trial Studied trt Control trt patientstagsROB Trial result2 yr MACE All cause death

acute myocardial infarction  

TYPHOON, 2006      NCTsirolimus eluting stentbare-metal stentsuggesting1%
SESAMI, 2007        NCTsirolimus eluting stentbare-metal stentRisk of bias suggesting-57%
MISSION, 2008   sirolimus eluting stentbare-metal stentRisk of bias suggesting-52%
Díaz de la Llera, 2007     sirolimus eluting stentbare-metal stent -
DEBATER (SES vs BMS), 2009   sirolimus eluting stentbare-metal stentsuggesting-35%
PROSIT, 2006   sirolimus eluting stentpaclitaxel eluting stentnegative-18%
Di Lorenzo et al., 2005     sirolimus eluting stentpaclitaxel eluting stentnegative-25%
Juwana, 2009     sirolimus eluting stentpaclitaxel eluting stentnegative44%

coronary artery disease  

ISAR-DESIRE (SES vs PTCA), 2005     sirolimus eluting stentballoon angioplastysuggesting-33%
Kochiadakis, 2007     sirolimus eluting stentbare-metal stentExploratory -
RAVEL, 2002      NCTsirolimus eluting stentbare-metal stentLow risk of bias suggesting-2%
SIRIUS, 2003            NCTsirolimus eluting stentbare-metal stentLow risk of bias suggesting64%
C-SIRIUS, 2004      NCTsirolimus eluting stentbare-metal stentLow risk of bias suggesting
E-SIRIUS, 2003      NCTsirolimus eluting stentbare-metal stentsuggesting102%
SES-SMART, 2004     sirolimus eluting stentbare-metal stentsuggesting-100%
DIABETES, 2005       sirolimus eluting stentbare-metal stentsuggesting-69%
Pache et al, 2005     sirolimus eluting stentbare-metal stentsuggesting40%
PRISON II, 2006      NCTsirolimus eluting stentbare-metal stentRisk of bias suggesting
SCANDSTENT, 2006      NCTsirolimus eluting stentbare-metal stentsuggesting-3%
TYPHOON, 2006      NCTsirolimus eluting stentbare-metal stentsuggesting1%
SESAMI, 2007        NCTsirolimus eluting stentbare-metal stentRisk of bias suggesting-57%
DECODE, 2005      NCTsirolimus eluting stentbare-metal stentsuggesting-100%
SCORPIUS, 2007    NCTsirolimus eluting stentbare-metal stentsuggesting
RRISC, 2006    NCTsirolimus eluting stentbare-metal stentRisk of bias suggesting43%∞%
MISSION, 2008   sirolimus eluting stentbare-metal stentRisk of bias suggesting-52%
Ortolani et al, 2007     sirolimus eluting stentbare-metal stent -
Pasceri, 2003   sirolimus eluting stentbare-metal stent -
Ravel (diabetics), 2004     sirolimus eluting stentbare-metal stentsuggesting
SES-SMARt (diabetics), 2005     sirolimus eluting stentbare-metal stentsuggesting-100%
GISSOC II, 2010      NCTsirolimus eluting stentbare-metal stentExploratory suggesting
Díaz de la Llera, 2007     sirolimus eluting stentbare-metal stent -
DESSERT, 2008   sirolimus eluting stentbare-metal stentExploratory suggesting54%
SIRIUS (diabetics), 2003     sirolimus eluting stentbare-metal stentLow risk of bias -
DEBATER (SES vs BMS), 2009   sirolimus eluting stentbare-metal stentsuggesting-35%
SCANDSTENT (subgroup), 2006     sirolimus eluting stentbare-metal stentExploratory suggesting
BASKET-PROVE (SES), 2010   sirolimus eluting stentbare-metal stentRisk of bias suggesting-47%-19%
CRISTAL    NCTsirolimus eluting stentPTCA -
RIBS-II, 2008   sirolimus eluting stentPTCAsuggesting-3%
SISR, 2007        NCTsirolimus eluting stentbrachytherapyRisk of bias suggesting
PRECOMBAT, 2011    NCTsirolimus eluting stentCABG -
Thiele, 2009    NCTPCI withsirolimus ESMIDCABRisk of bias -
Tomai, 2008     sirolimus eluting stentpaclitaxel eluting stent -
TAXi, 2005     sirolimus eluting stentpaclitaxel eluting stentRisk of bias negative
ISAR-DESIRE (SES vs PES), 2005     sirolimus eluting stentpaclitaxel eluting stentsuggesting100%
ISAR-DIABETES, 2005     sirolimus eluting stentpaclitaxel eluting stentnegative-33%
SIRTAX (Windecker), 2005     sirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting-54%
CORPAL, 2005   sirolimus eluting stentpaclitaxel eluting stentnegative-21%
REALITY, 2006      NCTsirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting74%
ISAR-SMART 3, 2006      NCTsirolimus eluting stentpaclitaxel eluting stentnegative-23%
Zhang (SES vs PES), 2006     sirolimus eluting stentpaclitaxel eluting stentExploratory negative-6%
LONG DES II, 2006     sirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting∞%
PROSIT, 2006   sirolimus eluting stentpaclitaxel eluting stentnegative-18%
SORT OUT II, 2008      NCTsirolimus eluting stentpaclitaxel eluting stentnegative
Cervinka, 2006     sirolimus eluting stentpaclitaxel eluting stentnegative∞%
Petronio et al, 2007     sirolimus eluting stentpaclitaxel eluting stentnegative-50%
Han, 2006   sirolimus eluting stentpaclitaxel eluting stentnegative-26%
BASKET (vs paclitaxel), 2005     sirolimus eluting stentpaclitaxel eluting stentnegative-3%
Di Lorenzo et al., 2005     sirolimus eluting stentpaclitaxel eluting stentnegative-25%
ISAR-TEST-1, 2006      NCTsirolimus eluting stentpaclitaxel eluting stentRisk of bias negative-33%
ISAR-DESIRE-2, 2010    NCTsirolimus eluting stentpaclitaxel eluting stentRisk of bias -
ISAR-LEFT-MAIN, 2009      NCTsirolimus eluting stentpaclitaxel eluting stentnegative-24%
SIRTAX (small vessels subgroup), 2005     sirolimus eluting stentpaclitaxel eluting stentsuggesting12%
Wessely, 2008     sirolimus eluting stentpaclitaxel eluting stentExploratory -
SIRTAX diabetics, 2005        NCTsirolimus eluting stentpaclitaxel eluting stentnegative
Kim, 2008   sirolimus eluting stentpaclitaxel eluting stentnegative-1%
TAxi (diabetics)   sirolimus eluting stentpaclitaxel eluting stent -
REALITY (diabetics), 2006   sirolimus eluting stentpaclitaxel eluting stentnegative
Pan, 2007   sirolimus eluting stentpaclitaxel eluting stentExploratory suggesting-34%
DES-DIABETES, 2008     sirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting-100%

stable angina  

Kochiadakis, 2007     sirolimus eluting stentbare-metal stentExploratory -
RAVEL, 2002      NCTsirolimus eluting stentbare-metal stentLow risk of bias suggesting-2%
SIRIUS, 2003            NCTsirolimus eluting stentbare-metal stentLow risk of bias suggesting64%
C-SIRIUS, 2004      NCTsirolimus eluting stentbare-metal stentLow risk of bias suggesting
E-SIRIUS, 2003      NCTsirolimus eluting stentbare-metal stentsuggesting102%
SES-SMART, 2004     sirolimus eluting stentbare-metal stentsuggesting-100%
DIABETES, 2005       sirolimus eluting stentbare-metal stentsuggesting-69%
Pache et al, 2005     sirolimus eluting stentbare-metal stentsuggesting40%
PRISON II, 2006      NCTsirolimus eluting stentbare-metal stentRisk of bias suggesting
SCANDSTENT, 2006      NCTsirolimus eluting stentbare-metal stentsuggesting-3%
DECODE, 2005      NCTsirolimus eluting stentbare-metal stentsuggesting-100%
SCORPIUS, 2007    NCTsirolimus eluting stentbare-metal stentsuggesting
Ortolani et al, 2007     sirolimus eluting stentbare-metal stent -
Pasceri, 2003   sirolimus eluting stentbare-metal stent -
GISSOC II, 2010      NCTsirolimus eluting stentbare-metal stentExploratory suggesting
DESSERT, 2008   sirolimus eluting stentbare-metal stentExploratory suggesting54%
Thiele, 2009    NCTPCI withsirolimus ESMIDCABRisk of bias -
Tomai, 2008     sirolimus eluting stentpaclitaxel eluting stent -
TAXi, 2005     sirolimus eluting stentpaclitaxel eluting stentRisk of bias negative
ISAR-DESIRE (SES vs PES), 2005     sirolimus eluting stentpaclitaxel eluting stentsuggesting100%
ISAR-DIABETES, 2005     sirolimus eluting stentpaclitaxel eluting stentnegative-33%
SIRTAX (Windecker), 2005     sirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting-54%
CORPAL, 2005   sirolimus eluting stentpaclitaxel eluting stentnegative-21%
REALITY, 2006      NCTsirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting74%
ISAR-SMART 3, 2006      NCTsirolimus eluting stentpaclitaxel eluting stentnegative-23%
Zhang (SES vs PES), 2006     sirolimus eluting stentpaclitaxel eluting stentExploratory negative-6%
LONG DES II, 2006     sirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting∞%
Cervinka, 2006     sirolimus eluting stentpaclitaxel eluting stentnegative∞%
Petronio et al, 2007     sirolimus eluting stentpaclitaxel eluting stentnegative-50%
Han, 2006   sirolimus eluting stentpaclitaxel eluting stentnegative-26%
BASKET (vs paclitaxel), 2005     sirolimus eluting stentpaclitaxel eluting stentnegative-3%
Di Lorenzo et al., 2005     sirolimus eluting stentpaclitaxel eluting stentnegative-25%
ISAR-TEST-1, 2006      NCTsirolimus eluting stentpaclitaxel eluting stentRisk of bias negative-33%
ISAR-LEFT-MAIN, 2009      NCTsirolimus eluting stentpaclitaxel eluting stentnegative-24%
Kim, 2008   sirolimus eluting stentpaclitaxel eluting stentnegative-1%