Edoxaban antithrombotics  

     

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Trial Studied trt Control trt patientstagsROB Trial resultCoronary eventmajor or clinically relevant non-major bleeding

atrial fibrillation  

Weitz (edoxaban phase 2)    NCTedoxabanwarfarin standard doseExploratory -
phase 2 edoxaban    NCTedoxabanwarfarin standard doseExploratory -
ENGAGE-AF TIMI 48 High dose, 2013    NCTedoxaban high dosewarfarin standard doseLow risk of bias suggesting -14%

thrombosis prevention  

STARS J-V    NCTedoxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting

venous thrombosis  

Hokusai-VTE Cancer, 2017      NCTedoxabandalteparinpatients with cancerRisk of bias negative
Edoxaban Hokusai VTE, 2013      NCTheparin/edoxabanheparin/VKA heparin - DOAC Low risk of bias suggesting-17%