Clopidogrel antiplatelets drug  

Iscover - Plavix      

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathMajor bleeding

acute coronary syndrome  

COMMIT, 2005      NCTclopidogrelplaceboLow risk of bias suggesting
CURE (PCI sub study), 2001     clopidogrelplaceboLow risk of bias -
CLARITY-TIMI 28, 2005   clopidogrelplaceboLow risk of bias -
CURE, 2001     clopidogrel + aspirinaspirinLow risk of bias suggesting 38%
CURRENT OASIS 7 (clopidogrel), 2010    NCTclopidogrel high-dose regimenclopidogrel standard-doseLow risk of bias negative -4%24%

acute myocardial infarction  

COMMIT, 2005      NCTclopidogrelplaceboLow risk of bias suggesting
CLARITY-TIMI 28, 2005   clopidogrelplaceboLow risk of bias -

atrial fibrillation  

ACTIVE W, 2006    NCTaspirin + clopidogrelanticoagulantRisk of bias suggesting 2%10%
ACTIVE A, 2009      NCTaspirin + clopidogrelaspirinLow risk of bias suggesting -2%57%

CABG surgery  

CASCADE, 2009      NCTclopidogrel+aspirinaspirinLow risk of bias -

cardiovascular prevention  

CAPRIE (PAD subgroup), 1996   clopidogrelaspirinLow risk of bias suggesting-19%
CAPRIE, 1996   clopidogrelaspirinsecondary preventionLow risk of bias suggesting-2%-12%
ASCET    NCTclopidogrelaspirinRisk of bias negative
CHARISMA, 2006      NCTclopidogrelplacebo (on top aspirin)secondary preventionLow risk of bias suggesting -1%25%

coronary artery disease  

CAPRIE, 1996     clopidogrelaspirinLow risk of bias -
ASCET    NCTclopidogrelaspirinRisk of bias negative

percutaneous coronary intervention  

REAL-LATE, ZEST-LATE, 2010      NCTclopidogrel+aspirinaspirinnegative52%197%
GRAVITAS, 2011      NCThigh-dose clopidogrelnormal-dose clopidogrelRisk of bias negative-30%
Müller, 2000     clopidogrel + aspirinticlopidine + aspirinnegative
CLASSICS, 2000     clopidogrel + aspirinticlopidine + aspirinnegative
TOPPS, 2001     clopidogrel + aspirinticlopidine + aspirinnegative
Piamsomboon, 2001   clopidogrel + aspirinticlopidine + aspirinnegative

peripheral vascular diseases  

CAPRIE (PAD subgroup), 1996   clopidogrelaspirinLow risk of bias suggesting-19%

post myocardial infarction  

CAPRIE, 1996     clopidogrelaspirinLow risk of bias -

stable angina  

ASCET    NCTclopidogrelaspirinRisk of bias negative

stent  

REAL-LATE, ZEST-LATE, 2010      NCTclopidogrel+aspirinaspirinnegative52%197%
GRAVITAS, 2011      NCThigh-dose clopidogrelnormal-dose clopidogrelRisk of bias negative-30%
Müller, 2000     clopidogrel + aspirinticlopidine + aspirinnegative
CLASSICS, 2000     clopidogrel + aspirinticlopidine + aspirinnegative
TOPPS, 2001     clopidogrel + aspirinticlopidine + aspirinnegative
Piamsomboon, 2001   clopidogrel + aspirinticlopidine + aspirinnegative