Crizotinib ALK inhibitors  

PF 02341066 - PF02341066 - PF-02341066 - Xalkori      

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Trial Studied trt Control trt patientstagsROB Trial resultprogression or death (progression free survival PFS) death (overall survival)

lung cancer (metastatic)  

Shaw, 2013      NCTcrizotinibchemotherapy2L 2nd line Risk of bias suggesting-51%2%
PROFILE 1014, 2014        NCTcrizotinibchemotherapy1L 1st line nonsquamous NSCLC Risk of bias suggesting-55%-18%