Ivabradine HR-slowing agents
systematic review meta-analysis network meta-analysis
 

S-16257 - S 16257 - S 16260-2 - S-16260-2 - S-16257-2 - S 16257-2 - Procorolan - Corlanor - ivabradine      

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathCV death, MI hospitalization for HF

heart failure  

SHIFT, 2010       ivabradineplaceboLow risk of bias suggesting-10%-18%
BEAUTIFUL, 2008    NCTivabradine 15mgplaceboLow risk of bias negative4%1%

stable angina  

Borer (CL2-009) 10mg, 2003     ivabradine 10mgplaceboLow risk of bias -
BEAUTIFUL, 2008    NCTivabradine 15mgplaceboLow risk of bias negative4%1%
Borer (CL2-009) 20mg, 2003   ivabradine 20mgplaceboLow risk of bias -
SIGNIFY, 2014     ivabradine 20mgplaceboLow risk of bias negative6%
Borer (CL2-009) 5mg, 2003     ivabradine 5mgplaceboLow risk of bias -
BEAUTIFUL (angina subgroup)   ivabradine 15mgplacebo (on top standard treatment)Low risk of bias suggesting-12%-23%
CL3-018 10mg   ivabradine 10mgplacebo on top of amlodipine -
CL3-018 15mg   ivabradine 15mgplacebo on top of amlodipine -
ASSOCIATE (Tardif), 2009    NCTivabradine 15mgplacebo on top of atenololLow risk of bias -
CL3-023 (15mg)   ivabradineamlodipineLow risk of bias -
CL3-023 (20mg)   ivabradineamlodipineLow risk of bias -
Ruzyllo (CL3-023) 15mg, 2007     ivabradine 15mgamlodipineLow risk of bias -
Ruzyllo (CL3-023) 20mg, 2007     ivabradine 20mgamlodipineLow risk of bias -
INITIATIVE (CL3-017, Tardif) 15mg, 2005   ivabradine 15mgatenololLow risk of bias -
INITIATIVE (CL3-017, Tardif) 20mg, 2005   ivabradine 20mgatenololLow risk of bias -



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