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Ezetimibe
cholesterol lowering intervention
systematic review
meta-analysis
network meta-analysis
Ezetrol - Zetia
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acute coronary syndrome
cardiovascular prevention
diabetes type 2
familial hypercholesterolemia
post myocardial infarction
ezetimibe
strategy
vs placebo or control
vs active treatment
early initiation
type 2 diabetes
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NCT results
cardiovascular events (5)
Cancer (5)
Coronary event (5)
All cause death (5)
Fatal stroke (5)
Cardiovascular death (5)
Coronary death (5)
stroke (fatal and non fatal) (5)
carotide IMT (4)
End stage renal disease (4)
Death from cancer (1)
Non fatal MI (1)
Coronary death and non fatal MI (1)
MACE (1)
LDL (1)
HDL (at 1 y) (1)
total cholesterol (at 1 y) (1)
Myopathy (1)
Rhabdomyolysis (1)
Adverse events (1)
non cardiovascular death (1)
cardiac death (1)
Haemmorhagic stroke (1)
new-onset diabetes (1)
Venous thromboembolism (1)
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Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
cardiovascular events
Cancer
acute coronary syndrome
IMPROVE-IT, 2014
NCT
ezetimibe
placebo (on top statins)
early initiation
Low risk of bias
conclusive
-6%
cardiovascular prevention
SHARP, 2010
NCT
ezetimibe+simvastatin
placebo
Low risk of bias
suggesting
-13%
-1%
Enhance, 2008
ezetimibe
placebo (on top statins)
Low risk of bias
-
IMPROVE-IT, 2014
NCT
ezetimibe
placebo (on top statins)
early initiation
Low risk of bias
conclusive
-6%
SANDS, 2008
NCT
aggressive treatment
standard teatment
diabetic
type 2 diabetes
Exploratory
negative
35%
ARBITER-HALTS 6, 2010
ezetimibe
niacin
Exploratory
-
diabetes type 2
SANDS, 2008
NCT
aggressive treatment
standard teatment
diabetic
type 2 diabetes
Exploratory
negative
35%
familial hypercholesterolemia
Enhance, 2008
ezetimibe
placebo (on top statins)
Low risk of bias
-
post myocardial infarction
IMPROVE-IT, 2014
NCT
ezetimibe
placebo (on top statins)
early initiation
Low risk of bias
conclusive
-6%
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