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Streptokinase
fibrinolysis
systematic review
meta-analysis
network meta-analysis
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acute myocardial infarction
pulmonary embolism
venous thrombosis
fibrinolysis
fibrinolytic
local fibrinolysis
systemic fibrinolysis
thrombolysis-facilitated PCI
vs placebo or control
vs other fibrinolytic
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Description
Synopsis
Comparison
Treatments
Patients
Characteristics
Method
Risk of bias
References
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Indexation
Results
Global trial result
Main results
All results
All result tag
NCT results
Major bleeding (14)
stroke (fatal and non fatal) (9)
Long term death (9)
reinfarction (9)
Cardiovascular death (8)
short term death (8)
Haemmorhagic stroke (8)
Mortality (early) (7)
Pulmonary embolism (early) (7)
Bleeding (early) (7)
Any improvement in venous patency (early) (7)
Complete clot lysis (early) (7)
Stroke/intracerebral bleeding (early) (7)
Leg ulceration (late) (7)
Mortality (late) (7)
Post-thrombotic syndrome (late) (7)
Complete clot lysis (late) (7)
Normal venous function (late) (7)
All cause death (5)
recurrence of pulmonary embolism (3)
Minor bleeding (3)
Initial TIMI 3 flow (2)
Final TIMI 3 flow (2)
Non fatal MI (2)
urgent target vessel revascularisation (2)
In-hospital death (1)
Emergency CABG (1)
Reocclusion (1)
CABG (1)
recurrent angina (1)
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medians
Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
Major bleeding
stroke (fatal and non fatal)
acute myocardial infarction
ISAM, 1986
streptokinase
placebo
Low risk of bias
negative
303%
ISIS-2 (SK), 1988
streptokinase
placebo
Low risk of bias
suggesting
156%
-9%
Western Washington Intravenous Trial, 1988
NCT
streptokinase
placebo
negative
2217%
GISSI I, 1986
streptokinase
placebo
suggesting
EMERAS (all delay), 1993
streptokinase
placebo
Low risk of bias
negative
ISIS 2 pilot, 1987
streptokinase
placebo
Low risk of bias
-
EMERAS (7-12h), 1993
streptokinase
placebo
Low risk of bias
-
SAMI (O’Neill), 1992
streptokinase
primary intervention
negative
715%
PRAGUE (Widimisky), 2000
streptokinase
primary intervention
negative
∞%
GUSTO tPA-SK Hiv, 1993
t-PA + streptokinase
streptokinase
negative
pulmonary embolism
Tibbutt, 1974
streptokinase
no fibrinolysis
Exploratory
negative
31%
Ly, 1978
streptokinase
no fibrinolysis
Exploratory
negative
57%
Jerjes-Sanchez, 1995
streptokinase
no fibrinolysis
Exploratory
-
venous thrombosis
Arneson, 1978
streptokinase
no fibrinolysis
negative
Common, 1976
streptokinase
no fibrinolysis
negative
Elsharawy, 2002
streptokinase
no fibrinolysis
negative
Schulman, 1986
streptokinase
no fibrinolysis
negative
Tsapogas, 1973
streptokinase
no fibrinolysis
negative
Kakkar (streptokinase), 1969
streptokinase
no fibrinolysis
negative
Schweizer (systemic SK), 2000
streptokinase
no fibrinolysis
-
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