T-pa fibrinolysis
systematic review meta-analysis network meta-analysis
 

     

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Trial Studied trt Control trt patientstagsROB Trial resultCardiovascular deathshort term death

acute coronary syndrome  

TIMI 3A, 1993   t-PAplaceboLow risk of bias -
Topol, 1988   t-PAplaceboExploratory negative
Nicklas, 1989   t-PAplaceboLow risk of bias negative
Gold, 1987   t-PAplaceboExploratory -
Williams, 1990   t-PAplaceboLow risk of bias negative
Freeman, 1992   t-PAplaceboLow risk of bias negative
van der Brand, 1991     t-PAplaceboLow risk of bias negative
charbonnier, 1992   t-PAplaceboLow risk of bias -
Ardissino, 1990     t-PAplaceboLow risk of bias negative
TIMI 3B, 1995     t-PAplaceboLow risk of bias -

acute myocardial infarction  

ASSET, 1988   t-PAplaceboLow risk of bias suggesting -26%
LATE, 1993   t-PAplaceboLow risk of bias negative-9%
TAMI 6, 1992   t-PAplaceboLow risk of bias negative5%
COBALT, 1997     bolus t-PAaccelerated t-PALow risk of bias negative6%
TIMI 4, 1994   accelerated t-PAAPSACLow risk of bias -
TAPS, 1992   accelerated t-PAAPSACnegative-71%
GUSTO tPA Hiv, 1993   accelerated t-PAstreptokinasesuggesting-14%
GISSI II, 1990   t-PAstreptokinasesuggesting 4%
International Study Group, 1990   t-PAstreptokinaseLow risk of bias suggesting 5%
Centre Illinois, 1993   t-PAstreptokinase -
Cherng, 1992   t-PAstreptokinasenegative
ECSG, 1985   t-PAstreptokinasenegative
PAIMS, 1989   t-PAstreptokinase -
TIMI-1, 1987    NCTt-PAstreptokinaseLow risk of bias -
White, 1989   t-PAstreptokinaseLow risk of bias -
ISIS III (SK/tPA), 1992   t-PAstreptokinaseLow risk of bias suggesting2%
RAAMI, 1992   accelerated t-PAt-PA -
KAMIT, 1991   t-PA half doset-PAExploratory negative
TAMI 5 (t-PA vs uroK), 1991   t-PAurokinase -

cardiac arrest  

Abu-Laban, 2002     t-PAplaceboLow risk of bias negative

venous thrombosis  

Verhaeghe (low dose), 1989   tPAno fibrinolysisLow risk of bias -
Verhaeghe (high dose), 1989   tPAno fibrinolysisLow risk of bias -
Turpie, 1990     tPAno fibrinolysisLow risk of bias negative
Schweizer (local tPA), 2000     tPAno fibrinolysis -
Goldhaber (tPA alone), 1990   tPAno fibrinolysisnegative
Goldhaber (tPA+heparin), 1990   tPAno fibrinolysis -



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