Ticagrelor antiplatelets drug  

AZD-6140 - AZD6140 - AZD 6140 - Brilinta - Brilique      

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Trial Studied trt Control trt patientstagsROB Trial resultMajor bleedingNon fatal MI

acute coronary syndrome  

PLATO, 2009      NCTticagrelorclopidogrelLow risk of bias suggesting3%
DISPERSE-2 (90mg), 2007       ticagrelorclopidogrelLow risk of bias negative-2%

cardiovascular prevention  

EUCLID, 2016        NCTticagrelorclopidogrelLow risk of bias -
PEGASUS 60mg, 2015        NCTticagrelorplacebo (on top aspirin)secondary preventionLow risk of bias suggesting 116%
PEGASUS 90mg, 2015        NCTticagrelorplacebo (on top aspirin)secondary preventionLow risk of bias suggesting 136%

peripheral vascular diseases  

EUCLID, 2016        NCTticagrelorclopidogrelLow risk of bias -

post myocardial infarction  

PEGASUS 60mg, 2015        NCTticagrelorplacebo (on top aspirin)secondary preventionLow risk of bias suggesting 116%
PEGASUS 90mg, 2015        NCTticagrelorplacebo (on top aspirin)secondary preventionLow risk of bias suggesting 136%