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Trial | Studied trt | Control trt | patients | tags | ROB | Trial result | Non fatal MI | cardiovascular events |
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FOLARDA (Liem), 2004 | folic acid | control | | | Exploratory | negative | | |
GOES (Liem), 2003 | folic acid | control | | | Risk of bias | negative | | |
NORVIT (folic acid + B12) (Bonaa), 2006 NCT | folic acid, B12 | control | | | Low risk of bias | negative | | |
NORVIT (folic acid, B12 and vit B6) (Bonaa), 2006 NCT | folic acid, vit B12 and vit B6 | control | | | Low risk of bias | negative | | |
CHAOS-2, 2002 | folic acid | placebo | | | Low risk of bias | negative | | |
CSPPT, 2015 NCT | folic acid | placebo | | | Low risk of bias | suggesting | | |
SEARCH, 2007 NCT | folic acid, B12 | placebo | | | Low risk of bias | negative | | |
WENBIT (folic ac,B12), 2008 NCT | folic acid, B12 | placebo | | | Low risk of bias | negative | | |
WAFACS, 2008 NCT | folic acid, vit B12 and vit B6 | placebo | | | Low risk of bias | negative | | |
HOPE-2 (Lonn), 2006 NCT | folic acid, vit B12 and vit B6 | placebo | | | Low risk of bias | suggesting | | |
VITATOPS, 2010 NCT | folic acid, vit B12 and vit B6 | placebo | | | Low risk of bias | suggesting | | |
SU.FOL.OM3 | folic acid, vit B12 and vit B6 | placebo | | | Low risk of bias | negative | | |
VISP (Toole), 2004 | high dose - folic acid, vit B12 and vit B6 | low dose - folic acid, vit B12 and vit B6 | | | Low risk of bias | negative | | |
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VITATOPS, 2010 NCT | folic acid, vit B12 and vit B6 | placebo | | | Low risk of bias | suggesting | | |
VISP (Toole), 2004 | high dose - folic acid, vit B12 and vit B6 | low dose - folic acid, vit B12 and vit B6 | | | Low risk of bias | negative | | |