Atezolizumab immune checkpoint inhibition  

RG-7446 - RG7446 - Tecentriq - MPDL3280A      

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Trial Studied trt Control trt patientstagsROB Trial resultdeath (overall survival) progression or death (progression free survival PFS)

lung cancer (metastatic)  

IMpower150 (WT), 2018      NCTatezolizumab + bevacizumabbevacizumab (on top platinum-based CT)1L 1st line nonsquamous NSCLC Risk of bias suggesting-38%
IMpower150 (Teff), 2018        NCTatezolizumab + bevacizumabbevacizumab (on top platinum-based CT)1L, Teff 1st line nonsquamous NSCLC Risk of bias suggesting-49%
POPLAR Phase 2 atezolizumab, 2016    NCTatezolizumabdocetaxel2L 2nd+ line platinum failure Risk of bias negative-27%
OAK, 2016      NCTatezolizumabdocetaxel2L 2nd+ line platinum failure Risk of bias suggesting-27%-5%

urothelial carcinoma (advanced)  

IMvigor211 (IC2/3)      NCTatezolizumabchemotherapy2nd line, IC2/3 2nd line Risk of bias suggesting-13%
IMVIGOR-130 (monotherapy)    NCTatezolizumabcontrolfirst line 1st line Risk of bias remark
IMvigor210 single-arm      NCTatezolizumabnil1st and 2nd line 1st line 2nd line Exploratory -