Ribociclib CDK (cyclin-dependent kinase) inhibitor  

LEE011 - ribociclib      

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Trial Studied trt Control trt patientstagsROB Trial resultprogression or death (progression free survival PFS) death (overall survival)

advanced breast cancer (metastatic)  

MONALEESA-2, 2016        NCTribociclib (LEE011) + letrozoleletrozole alonefirst line 1st line HER-2 negative HR positive postmenopausal Low risk of bias conclusive-44%