Losartan angiotensin-receptor blockers  

Losartan Monopotassium Salt - Losartan Potassium - DuP753 - DuP 753 - DuP-753 - MK954 - MK 954 - MK-954 - Cozaar - Losartan      

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Trial Studied trt Control trt patientstagsROB Trial resultAdverse eventsAll cause death

acute myocardial infarction  

OPTIMAAL, 2002     LosartanCaptoprilLow risk of bias suggesting

atrial fibrillation  

LIFE (AF ancillary study), 2005     losartanatenololsuggesting

diabetes type 2  

RENAAL, 2001     losartanplaceboLow risk of bias suggesting2%
LIFE (diabetic subgroup), 2002       losartanatenololLow risk of bias suggesting-39%

diabetic kidney disease  

RENAAL, 2001     losartanplaceboLow risk of bias suggesting2%

heart failure  

HEAAL, 2009        NCTlosartan 150mglosartan 50mgLow risk of bias suggesting11%-6%
Losartan Phase III International, 1996       losartanplaceboLow risk of bias suggesting-83%
Losartan Phase III U.S., 1995     losartanplaceboLow risk of bias negative-52%
Hamroff et al., 1999     losartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
ELITE, 1997       losartancaptoprilLow risk of bias negative
ELITE II, 2000     losartancaptoprilLow risk of bias -
Dickstein et al., 1995     losartanenalaprilLow risk of bias -
Lang et al., 1997     losartanenalaprilLow risk of bias -
Losartan phase II S, 1996     losartanenalaprilLow risk of bias -
losartan phase II US, 1996     losartanenalaprilLow risk of bias -

hypertension  

RENAAL, 2001     losartanplaceboLow risk of bias suggesting2%
RENAAL, 2001     losartanplaceboLow risk of bias -
LIFE, 2002     losartanatenololLow risk of bias suggesting -11%
LIFE (diabetic subgroup), 2002       losartanatenololLow risk of bias suggesting-39%
ELITE, 1997     LosartanCaptoprilLow risk of bias suggesting-44%
ELITE-II, 2000     LosartanCaptoprilLow risk of bias negative12%
OPTIMAAL, 2001     LosartanCaptoprilRisk of bias negative 11%

miscellaneous  

RENAAL, 2001     losartanplaceboLow risk of bias -
LIFE, 2002     losartanatenololLow risk of bias suggesting -11%

patients at high risk for cardiovascular events  

RENAAL, 2001     losartanplaceboLow risk of bias -
LIFE, 2002     losartanatenololLow risk of bias suggesting -11%