Captopril angiotensin-Converting Enzyme Inhibitors  

Lopirin - Capoten - SQ14225 - SQ 14225 - SQ-14225 - SQ14534 - SQ 14534 - SQ-14534      

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathNYHA class improvement

acute myocardial infarction  

Hargreaves, 1992   captoprilplaceboLow risk of bias -
Galcera, 1993   captoprilplaceboLow risk of bias -
Di Pasquale, 1997   captoprilplaceboLow risk of bias -
Nabel, 1991   captoprilplaceboLow risk of bias -
Di Pasquale, 1994   captoprilplaceboLow risk of bias -
Bussmann, 1992   captoprilplaceboLow risk of bias -
Ray, 1993     captoprilplaceboLow risk of bias -
Sharpe, 1991     captoprilplaceboLow risk of bias -
ECCE, 1997   captoprilplaceboLow risk of bias -
ISIS-4, 1995   captoprilplaceboLow risk of bias - -6%
CCS-1, 1995   captoprilplaceboLow risk of bias -
SAVE, 1992   captoprilplaceboLow risk of bias -
CATS, 1996     captoprilplaceboLow risk of bias -
Sharpe, 1988     captoprilplaceboLow risk of bias -
French, 1999     captoprilplaceboLow risk of bias -
Mortarino, 1990   captoprilplaceboLow risk of bias -
Sogaard, 1994   captoprilplaceboLow risk of bias -
Pfeffer, 1988   captoprilplaceboLow risk of bias -
PRACTICAL (captopril), 1994   captopril or enalaprilplaceboLow risk of bias -

diabetes type 2  

UKPDS 38, 1998     captopril or atenololcontrolExploratory suggesting -17%
UKPDS 39, 1998     captoprilatenololExploratory negative 14%
CAPP (diabetic subgroup), 1999       captoprildiuretic and/or beta-blockersExploratory suggesting -46%

heart failure  

Pfeffer, 1988   captoprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group (capt vs pbo), 1995   captoprilplaceboLow risk of bias -
Sogaard, 1994   captoprilplaceboLow risk of bias -
Sharpe, 1988     captoprilplaceboLow risk of bias -
CMRG, 1983   captoprilplaceboLow risk of bias -
Mortarino, 1990   captoprilplaceboLow risk of bias -
Magnani, 1990   captoprilplaceboLow risk of bias -
SAVE, 1992   captoprilplaceboLow risk of bias -
Barabino, 1991   captoprilplaceboLow risk of bias suggesting
Captopril Digoxin Multicenter Research Group, 1988   captoprilplaceboLow risk of bias negative 88%
Bussmann, 1987   captoprilplaceboLow risk of bias negative-39%
Magnani, 1986   captoprilplaceboLow risk of bias -
Munich MHFT (Kleber), 1992   captoprilplaceboLow risk of bias negative5%
packer, 1986   captoprilenalaprilExploratory -

hypertension  

UKPDS 38, 1998     captopril or atenololcontrolExploratory suggesting -17%
UKPDS 39, 1998     captoprilatenololExploratory negative 14%
VALIANT/Val+Cap, 2003       Valsartan + captoprilCaptoprilLow risk of bias negative-1%
CAPP (diabetic subgroup), 1999       captoprildiuretic and/or beta-blockersExploratory suggesting -46%
CAPPP, 1999     captoprildiuretic or beta-blockerRisk of bias negative -3%
UKPDS-HDS, 1998       captoprildiuretic or beta-blockernegative14%