Ezetimibe cholesterol lowering intervention  

Ezetrol - Zetia      

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Trial Studied trt Control trt patientstagsROB Trial resultcardiovascular eventsCancer

acute coronary syndrome  

IMPROVE-IT, 2014      NCTezetimibeplacebo (on top statins) early initiation Low risk of bias conclusive-6%

cardiovascular prevention  

SHARP, 2010      NCTezetimibe+simvastatinplaceboLow risk of bias suggesting-13%-1%
Enhance, 2008   ezetimibeplacebo (on top statins)Low risk of bias -
IMPROVE-IT, 2014      NCTezetimibeplacebo (on top statins) early initiation Low risk of bias conclusive-6%
SANDS, 2008      NCTaggressive treatmentstandard teatmentdiabetic type 2 diabetes Exploratory negative35%
ARBITER-HALTS 6, 2010   ezetimibeniacinExploratory -

diabetes type 2  

SANDS, 2008      NCTaggressive treatmentstandard teatmentdiabetic type 2 diabetes Exploratory negative35%

familial hypercholesterolemia  

Enhance, 2008   ezetimibeplacebo (on top statins)Low risk of bias -

post myocardial infarction  

IMPROVE-IT, 2014      NCTezetimibeplacebo (on top statins) early initiation Low risk of bias conclusive-6%