Nadroparin LMWH  

LMF CY216 - LMF CY 216 - LMF CY-216 - CY216 - CY-216 - CY 216 - Fraxiparine - Fraxiparin - Nadroparine      

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathMajor bleeding

acute coronary syndrome  

FRAXIS (6days), 1998     nadroparinUFH (on top of aspirin)Low risk of bias negative6%
FRAXIS (14 days), 1998     nadroparinUFH (on top of aspirin)Low risk of bias negative26%

pulmonary embolism  

European multicentre study, 1991   Nadroparinunfractionated heparinRisk of bias negative
Prandoni sub-group, 1992       Nadroparinunfractionated heparinExploratory negative
Thery, 1992   Nadroparinunfractionated heparinExploratory negative

superficial thrombophlebitis  

Vesalio, 2005     nadroparin fixed-dosenadroparin weight-adjusted -
Titon (nadroparin 0.6ml vs naproxen), 1994   nadroparinnaproxene -
Titon (nadroparin 61.5 IU anti-Xa/kg vs naproxen), 1994   nadroparinnaproxene -

thrombosis prevention  

KANT (7 days), 2008   nadroparincontrolRisk of bias suggesting
Kujath, 1993   nadroparincontrolRisk of bias suggesting
KANT (14 days), 2008   nadroparin 14dcontrolRisk of bias suggesting
Yoo, 1997     nadroparinno treatmenthip surgerynegative
Marassi [41]   nadroparinno treatmentnegative
Sourmelis, 1995   nadroparinplacebohip surgeryLow risk of bias suggesting
Fraisse, 2000     Nadroparinplacebomedical patientsLow risk of bias negative5%109%
Mahe, 2005   Nadroparinplacebomedical patientsLow risk of bias negative-2%-66%
Balas [40]   nadroparinplacebonegative
Nurmohamed, 1996   nadroparinplacebonegative
Bergmann, 1996   nadroparinplacebomedical patientsnegative-2%
NPHDO, 1998   out of hospital Nadroparinstandard prophylaxisnegative
Kakkar and Murray, 1985   nadroparinunfractionated heparingeneral surgerysuggesting-17%
EFS, 1988   nadroparinunfractionated heparinabdominal surgerysuggesting-11%
Dahan, 1989   nadroparinunfractionated heparinthoracic surgerynegative
Barbui, 1990   nadroparinunfractionated heparingeneral surgery -
Eurin, 1994   nadroparinunfractionated heparinabdominal surgery -

venous thrombosis  

Lopaciuk, 1999     NadroparinacenocoumarolRisk of bias negative
Lopez-Beret, 2001     NadroparinacenocoumarolRisk of bias negative
Lopez Beret, 2001     extended nadroparinstandard treatmentnegative24%
Charbonnier, 1998     once daily nadroparintwice daily nadroparinLow risk of bias negative-27%
Collaborative European Multicentre, 1991   Nadroparinunfractionated heparinnegative89%
Prandoni et al , 1992   Nadroparinunfractionated heparinsuggesting-50%
Lopaciuk et al , 1992   Nadroparinunfractionated heparinnegative-100%