Dalteparin LMWH  

     

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathMajor bleeding

acute coronary syndrome  

FRISC (long term), 1996   dalteparinplacebo (on top of aspirin)Low risk of bias suggesting-15%
FRISC (short term), 1996   dalteparinplacebo (on top of aspirin)Low risk of bias -
FRIC prolonged treatment phase (LWMH vs PBO), 1997     dalteparinplacebo (on top of aspirin)Low risk of bias negative61%
FRIC (acute phase LMWH vs UFH), 1997     dalteparinUFH (on top of aspirin)Exploratory negative257%

acute myocardial infarction  

BIOMACS II, 1999     DalteparinplaceboLow risk of bias -
FRAMI, 1997     Dalteparinplacebo -
ASSENT Plus, 2003     DalteparinUFHnegative

percutaneous coronary intervention  

Natarajan (without antiGp2b3a), 2003   dalteparinUFH -
Natarajan (+ antiGp2b3a), 2003   dalteparinUFH + anti Gp2b3a -

pulmonary embolism  

Kuijer, 1995   Dalteparinunfractionated heparinnegative
Meyer, 1995   Dalteparinunfractionated heparinnegative

thrombosis prevention  

Lapidus, 2007     dalteparinplaceboLow risk of bias negative
Lapidus, 2007     dalteparinplaceboLow risk of bias negative
D-KAf (Selby), 2007      NCTdalteparinplacebonegative
Leizorovicz, 2004     dalteparinplacebomedical patientsLow risk of bias suggesting2%∞%
Jorgensen, 1989   dalteparinplacebohip surgeryLow risk of bias suggesting-100%
Torholm, 1991     dalteparinplacebohip surgeryLow risk of bias suggesting∞%
Ockelford , 1989   dalteparinplacebosuggesting-100%-7%
Matzsch , 1991   dalteparinDextranhip surgerysuggesting
Eriksson , 1988   dalteparinDextranhip surgerysuggesting
Matzsch , 1988   dalteparinDextranhip surgerynegative
Lassen, 1998     out of hospital Dalteparinstandard prophylaxisnegative-100%
Dahl, 1997   out of hospital Dalteparinstandard prophylaxissuggesting-2%
Hull, 2000     out of hospital Dalteparinstandard prophylaxissuggesting-100%
PROTECT, 2011    NCTdalteparinUFHmedical patientsLow risk of bias suggesting-10%-2%
Scala, 1990   dalteparinUFHRisk of bias negative-5%
Haas , 1985   dalteparinUnfractionated heparinhip surgerynegative
Binsack , 1986   dalteparinUnfractionated heparinhip surgerynegative
Barre , 1987   dalteparinUnfractionated heparinhip surgerynegative
Dechavanne , 1989   dalteparinUnfractionated heparinhip surgerynegative
Eriksson , 1989   dalteparinUnfractionated heparinhip surgerysuggesting-100%
Monreal , 1989   dalteparinUnfractionated heparinhip surgerynegative-36%
Creperio, 1990   dalteparinunfractionated heparingeneral surgerynegative
Hartl, 1990   dalteparinunfractionated heparinabdominal surgerysuggesting48%-34%
Borstad, 1992   dalteparinunfractionated heparingynaecological surgery -
Fricker, 1988   dalteparinunfractionated heparinabdominal surgerynegative100%
Koller, 1986   dalteparinunfractionated heparinabdominal surgerynegative∞%
Koller, 1986   dalteparinunfractionated heparinabdominal surgerynegative 161%
Onarheim, 1986   dalteparinunfractionated heparinabdominal surgerynegative8%
Bergqvist, 1988   dalteparinunfractionated heparinabdominal surgerynegative -2%
Bergqvist, 1986   dalteparinunfractionated heparinabdominal surgerynegative 236%
Caen, 1988   dalteparinunfractionated heparinabdominal surgerynegative-35%-100%
Borstad, 1988   dalteparinunfractionated heparingynaecological surgerynegative5%
Briel, 1988   dalteparinunfractionated heparinnon orthopedic surgerynegative
Kakkar, 1993   dalteparinunfractionated heparinabdominal surgery -

venous thrombosis  

CLOT (Lee), 2003     extended dalteparinstandard treatmentsuggesting-4%57%
Das, 1996     DalteparinwarfarinRisk of bias negative
Lee, 2003       DalteparinwarfarinRisk of bias suggesting
Holmström, 1992   once daily dalteparintwice daily dalteparinnegative
Partsch, 1996     once daily dalteparintwice daily dalteparinnegative153%
Holm et al , 1986   Dalteparinunfractionated heparinnegative
Bratt et al, 1990   Dalteparinunfractionated heparinnegative83%
Lindmarker et al , 1993   Dalteparinunfractionated heparinnegative-32%
Bratt et al , 1985   Dalteparinunfractionated heparinnegative