anti hypertensive agents

     

pathologytreatmentpatient Demonstrated benefit and harm k      
diabetes type 2amlodipinenot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2amlodipinenot classified

versus angiotensin-converting enzyme inhibitors

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2amlodipinenot classified

versus diuretics

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2candesartannot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2captoprilnot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2captoprilnot classified

versus beta-blockers

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2captoprilnot classified

versus diuretic and/or beta-blocker

No demonstrated result for efficacy

captopril inferior to diuretic and/or beta-blockers in terms of Fatal and nonfatal MI in CAPP (diabetic subgroup), 1999

1 trialmeta-analysis
diabetes type 2chlorthalidonenot classified

versus placebo or control

No demonstrated result for efficacy

chlorthalidone inferior to placebo in terms of Fatal and nonfatal MI in SHEP (diabetic subgroup), 1996

1 trialmeta-analysis
diabetes type 2intensive blood pressure lowering strategiesnot classified

versus standard target

No demonstrated result for efficacy

2 trialsmeta-analysis
diabetes type 2irbesartannot classified

versus placebo or control

No demonstrated result for efficacy

2 trialsmeta-analysis
diabetes type 2irbesartannot classified

versus calcium-channel blockers

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2lisinoprilnot classified

versus diuretics

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2losartannot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2losartannot classified

versus beta-blockers

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2metoprololnot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2nidrendipinenot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2nifedipinenot classified

versus diuretics

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2nisoldipinenot classified

versus angiotensin-converting enzyme inhibitors

No demonstrated result for efficacy

1 trialmeta-analysis
diabetes type 2olmesartannot classified

versus placebo or control

No demonstrated result for efficacy

olmesartan inferior to placebo in terms of CV death in ROADMAP, 2010

2 trialsmeta-analysis
diabetes type 2ramiprilnot classified

versus placebo or control

No demonstrated result for efficacy

2 trialsmeta-analysis
hypertensionaliskiren not classified

versus

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionaliskiren not classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionaliskiren not classified

versus angiotensin receptor blocker

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionaliskiren not classified

versus angiotensin-converting enzyme inhibitors

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionaliskiren not classified

versus diuretics

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionamlodipinenot classified

versus placebo or control

No demonstrated result for efficacy

3 trialsmeta-analysis
hypertensionamlodipinenot classified

versus angiotensin-converting enzyme inhibitors

No demonstrated result for efficacy

2 trialsmeta-analysis
hypertensionamlodipinenot classified

versus beta-blockers

No demonstrated result for efficacy

2 trialsmeta-analysis
hypertensionamlodipinenot classified

versus diuretics

No demonstrated result for efficacy

amlodipine inferior to chlorthalidone in terms of heart failure in ALLHAT (CCB vs diu), 2002

amlodipine inferior to chlorthalidone in terms of Coronary revascularization in ALLHAT (CCB vs diu), 2002

3 trialsmeta-analysis
hypertensionatenololnot classified

versus placebo or control

No demonstrated result for efficacy

6 trialsmeta-analysis
hypertensionatenololnot classified

versus diuretics

No demonstrated result for efficacy

atenolol inferior to bendroflumethiazide in terms of Myocardial infarction (fatal & non fatal) in MRC I (vs diuretics), 1985

atenolol inferior to hydrochlorothiazide+amiloride in terms of cardiovascular death in MRC old (vs diuretics), 1992

atenolol inferior to hydrochlorothiazide+amiloride in terms of Myocardial infarction (fatal & non fatal) in MRC old (vs diuretics), 1992

atenolol inferior to hydrochlorothiazide+amiloride in terms of cardiovascular events in MRC old (vs diuretics), 1992

2 trialsmeta-analysis
hypertensioncandesartannot classified

versus

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensioncandesartannot classified

versus placebo or control

No demonstrated result for efficacy

8 trialsmeta-analysis
hypertensioncandesartannot classified

versus calcium-channel blockers

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensioncandesartannot classified

versus diuretics

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensioncaptoprilnot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensioncaptoprilnot classified

versus beta-blockers

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensioncaptoprilnot classified

versus diuretic and/or beta-blocker

No demonstrated result for efficacy

captopril inferior to diuretic and/or beta-blockers in terms of Fatal and nonfatal MI in CAPP (diabetic subgroup), 1999

1 trialmeta-analysis
hypertensioncaptoprilnot classified

versus diuretic or beta-blocker

No demonstrated result for efficacy

captopril inferior to diuretic or beta-blocker in terms of stroke (fatal & non fatal) in CAPPP, 1999

2 trialsmeta-analysis
hypertensioncarvedilolnot classified

versus placebo or control

No demonstrated result for efficacy

2 trialsmeta-analysis
hypertensionchlorthalidonenot classified

versus placebo or control

No demonstrated result for efficacy

chlorthalidone inferior to placebo in terms of Coronary event in SHEP, 1991

chlorthalidone inferior to placebo in terms of Heart failure in SHEP, 1991

chlorthalidone inferior to placebo in terms of Stroke in SHEP, 1991

chlorthalidone inferior to placebo in terms of Fatal and nonfatal MI in SHEP (diabetic subgroup), 1996

6 trialsmeta-analysis
hypertensiondiltiazemnot classified

versus diuretic or beta-blocker

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionenalaprilnot classified

versus calcium-channel blockers

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionenalaprilnot classified

versus diuretics

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionfosinoprilnot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionhydrochlorothiazide not classified

versus placebo or control

No demonstrated result for efficacy

3 trialsmeta-analysis
hypertensionindapamidenot classified

versus

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionindapamidenot classified

versus placebo or control

No demonstrated result for efficacy

indapamide inferior to placebo in terms of Stroke in PATS, 1995

indapamide inferior to placebo in terms of cardiovascular event in PATS, 1995

indapamide inferior to placebo in terms of All-cause death in HYVET, 2008

indapamide inferior to placebo in terms of Heart failure in HYVET, 2008

2 trialsmeta-analysis
hypertensionindapamidenot classified

versus beta-blockers

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionintensive blood pressure lowering strategiesnot classified

versus standard target

No demonstrated result for efficacy

2 trialsmeta-analysis
hypertensionirbesartannot classified

versus placebo or control

No demonstrated result for efficacy

4 trialsmeta-analysis
hypertensionirbesartannot classified

versus calcium-channel blockers

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionisradipinenot classified

versus diuretics

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionlacidipinenot classified

versus beta-blockers

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionlacidipinenot classified

versus diuretics

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionlisinoprilnot classified

versus calcium-channel blockers

No demonstrated result for efficacy

lisinopril inferior to amlodipine in terms of stroke (fatal & non fatal) in ALLHAT (ACEI vs amlodipine), 2002

1 trialmeta-analysis
hypertensionlisinoprilnot classified

versus diuretics

No demonstrated result for efficacy

lisinopril inferior to diuretics in terms of heart failure in ALLHAT (ACEI vs chlorthalidone), 2002

lisinopril inferior to diuretics in terms of stroke (fatal & non fatal) in ALLHAT (ACEI vs chlorthalidone), 2002

lisinopril inferior to diuretics in terms of Major cardiovascular events in ALLHAT (ACEI vs chlorthalidone), 2002

2 trialsmeta-analysis
hypertensionlosartannot classified

versus placebo or control

No demonstrated result for efficacy

2 trialsmeta-analysis
hypertensionlosartannot classified

versus beta-blockers

No demonstrated result for efficacy

losartan inferior to atenolol in terms of PAD inférieure à 90 in LIFE, 2002

losartan inferior to atenolol in terms of lung cancer in LIFE, 2002

2 trialsmeta-analysis
hypertensionnicardipinenot classified

versus diuretics

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionnidrendipinenot classified

versus placebo or control

No demonstrated result for efficacy

3 trialsmeta-analysis
hypertensionnifedipinenot classified

versus diuretic + beta-blocker

No demonstrated result for efficacy

nifedipine inferior to atenolol+chlorthalidone in terms of all cause death in Castel, 1994

nifedipine inferior to atenolol+chlorthalidone in terms of heart failure in Castel, 1994

nifedipine inferior to atenolol+chlorthalidone in terms of Major cardiovascular events in Castel, 1994

1 trialmeta-analysis
hypertensionnifedipinenot classified

versus diuretics

No demonstrated result for efficacy

nifedipine inferior to hydrochlorothiazide+amiloride in terms of fatal MI in INSIGHT, 2000

2 trialsmeta-analysis
hypertensionnisoldipinenot classified

versus angiotensin-converting enzyme inhibitors

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionoxprenololnot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionpropranololnot classified

versus diuretics

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionramiprilnot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionramiprilnot classified

versus beta-blockers

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionramiprilnot classified

versus calcium-channel blockers

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensiontelmisartannot classified

versus placebo or control

No demonstrated result for efficacy

2 trialsmeta-analysis
hypertensionthiazid diureticnot classified

versus placebo or control

No demonstrated result for efficacy

thiazide diuretics inferior to control in terms of Stroke in ANBPS (Australian ), 1980

thiazide diuretics inferior to placebo in terms of Stroke in MCR 35-64 (diuretics vs pbo), 1985

thiazide diuretics inferior to control in terms of Stroke in Carter, 1970

4 trialsmeta-analysis
hypertensionvarious ACEInot classified

versus calcium-channel blockers

No demonstrated result for efficacy

2 trialsmeta-analysis
hypertensionvarious ACEInot classified

versus diuretic or beta-blocker

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionvarious beta blockersnot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionvarious beta blockersnot classified

versus diuretics

No demonstrated result for efficacy

2 trialsmeta-analysis
hypertensionvarious diureticsnot classified

versus placebo or control

No demonstrated result for efficacy

High-dose diuretics inferior to placebo in terms of Cardiovascular death in VA II, 1970

High-dose diuretics inferior to placebo in terms of Stroke in VA II, 1970

4 trialsmeta-analysis
hypertensionvarious diureticsnot classified

versus beta-blockers

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionverapamilnot classified

versus beta-blockers

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionverapamilnot classified

versus diuretic or beta-blocker

No demonstrated result for efficacy

1 trialmeta-analysis
hypertensionverapamilnot classified

versus diuretics

No demonstrated result for efficacy

1 trialmeta-analysis
post stroketelmisartannot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis