antiarrythmic drugs

Amiodarone - Dronedarone - Flecainide - Lidocaine - Propafenone      

pathologytreatmentpatient Demonstrated benefit and harm k      
acute myocardial infarctiondofetilidenot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
acute myocardial infarctionmagnesiumnot classified

versus placebo or control

No demonstrated result for efficacy

magnesium inferior to control in terms of Heart failure in ISIS-4, 1995

magnesium inferior to control in terms of Profound hypotension in ISIS-4, 1995

magnesium inferior to control in terms of II-III heart block in ISIS-4, 1995

magnesium inferior to control in terms of Cardiogenic shock in ISIS-4, 1995

magnesium inferior to control in terms of Bradycardia in ISIS-4, 1995

magnesium inferior to placebo in terms of Heart failure in Morton, 1984

magnesium inferior to placebo in terms of II-III heart block in Morton, 1984

magnesium inferior to placebo in terms of Bradycardia in Woods, 1992

25 trialsmeta-analysis
acute myocardial infarctionmoricizinenot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
atrial fibrillationamiodaronenot classified

versus placebo or control

No demonstrated result for efficacy

4 trialsmeta-analysis
atrial fibrillationamiodaronenot classified

versus Class I

No demonstrated result for efficacy

2 trialsmeta-analysis
atrial fibrillationamiodaronenot classified

versus Class Ia

No demonstrated result for efficacy

2 trialsmeta-analysis
atrial fibrillationamiodaronenot classified

versus Class Ic

No demonstrated result for efficacy

amiodarone inferior to propafenone in terms of Withdrawals due to adverse effects in Kochiadakis a, 2004

1 trialmeta-analysis
atrial fibrillationamiodaronenot classified

versus Class III

No demonstrated result for efficacy

3 trialsmeta-analysis
atrial fibrillationAzimilidenot classified

versus placebo or control

No demonstrated result for efficacy

Azimilide inferior to placebo in terms of Withdrawals due to adverse effects in ASAP, 2003

1 trialmeta-analysis
atrial fibrillationdisopyramidenot classified

versus placebo or control

No demonstrated result for efficacy

2 trialsmeta-analysis
atrial fibrillationdisopyramidenot classified

versus Class Ia

No demonstrated result for efficacy

1 trialmeta-analysis
atrial fibrillationdisopyramidenot classified

versus Class Ic

No demonstrated result for efficacy

1 trialmeta-analysis
atrial fibrillationdofetilidenot classified

versus placebo or control

No demonstrated result for efficacy

2 trialsmeta-analysis
atrial fibrillationdronedaronenot classified

versus placebo or control

No demonstrated result for efficacy

dronedarone inferior to placebo in terms of Withdrawals due to adverse effects in ATHENA, 2009

dronedarone inferior to placebo in terms of Stroke in PALLAS, 2011

dronedarone inferior to placebo in terms of HF hospitalization in PALLAS, 2011

dronedarone inferior to placebo in terms of Cardiovascular events in PALLAS, 2011

dronedarone inferior to placebo in terms of Death, unplanned CV hospitalization in PALLAS, 2011

7 trialsmeta-analysis
atrial fibrillationdronedaronenot classified

versus amiodarone

No demonstrated result for efficacy

dronedarone inferior to amiodarone in terms of Atrial fibrillation recurrence in DIONISOS, 2007

1 trialmeta-analysis
atrial fibrillationflecainidenot classified

versus placebo or control

No demonstrated result for efficacy

2 trialsmeta-analysis
atrial fibrillationflecainidenot classified

versus Class Ia

No demonstrated result for efficacy

flecainide inferior to quinidine in terms of Withdrawals due to adverse effects in Naccarelli, 1996

1 trialmeta-analysis
atrial fibrillationflecainidenot classified

versus Class Ic

No demonstrated result for efficacy

1 trialmeta-analysis
atrial fibrillationflecainidenot classified

versus digoxin

No demonstrated result for efficacy

1 trialmeta-analysis
atrial fibrillationmetoprololnot classified

versus placebo or control

No demonstrated result for efficacy

metoprolol inferior to placebo in terms of Withdrawals due to adverse effects in Kuhlkamp, 2000

1 trialmeta-analysis
atrial fibrillationpropafenonenot classified

versus placebo or control

No demonstrated result for efficacy

5 trialsmeta-analysis
atrial fibrillationpropafenonenot classified

versus Class Ia

No demonstrated result for efficacy

propafenone inferior to quinidine in terms of Withdrawals due to adverse effects in Richiardi, 1992

1 trialmeta-analysis
atrial fibrillationpropafenonenot classified

versus Class Ic

No demonstrated result for efficacy

1 trialmeta-analysis
atrial fibrillationpropafenonenot classified

versus Class III

No demonstrated result for efficacy

1 trialmeta-analysis
atrial fibrillationquinidinenot classified

versus placebo or control

No demonstrated result for efficacy

quinidine inferior to no treatment in terms of Withdrawals due to adverse effects in Sodermark, 1975

6 trialsmeta-analysis
atrial fibrillationquinidinenot classified

versus Class Ia

No demonstrated result for efficacy

1 trialmeta-analysis
atrial fibrillationquinidinenot classified

versus Class Ic

No demonstrated result for efficacy

1 trialmeta-analysis
atrial fibrillationquinidinenot classified

versus Class III

No demonstrated result for efficacy

quinidine inferior to sotalol in terms of Withdrawals due to adverse effects in Hohnloser, 1995

quinidine inferior to sotalol in terms of Withdrawals due to adverse effects in Juul-Moller, 1990

6 trialsmeta-analysis
atrial fibrillationquinidinenot classified

versus digoxin

No demonstrated result for efficacy

1 trialmeta-analysis
atrial fibrillationsotalolnot classified

versus placebo or control

No demonstrated result for efficacy

sotalol inferior to placebo in terms of Withdrawals due to adverse effects in Benditt, 1999

9 trialsmeta-analysis
atrial fibrillationsotalolnot classified

versus Class Ic

No demonstrated result for efficacy

2 trialsmeta-analysis
atrial fibrillationsotalolnot classified

versus Class II

No demonstrated result for efficacy

1 trialmeta-analysis
cardiac arrestamiodaronenot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
cardiac arrestamiodaronenot classified

versus lidocaine

No demonstrated result for efficacy

1 trialmeta-analysis
heart failureamiodaronenot classified

versus placebo or control

No demonstrated result for efficacy

5 trialsmeta-analysis
heart failureamiodaronenot classified

versus

No demonstrated result for efficacy

1 trialmeta-analysis
heart failuredronedaronenot classified

versus placebo or control

No demonstrated result for efficacy

dronedarone inferior to placebo in terms of All cause death in ANDROMEDA, 2008

1 trialmeta-analysis
post myocardial infarctionamiodaronenot classified

versus placebo or control

No demonstrated result for efficacy

5 trialsmeta-analysis
post myocardial infarctionAzimilidenot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
post myocardial infarctiondofetilidenot classified

versus placebo or control

No demonstrated result for efficacy

1 trialmeta-analysis
post myocardial infarctionmoricizinenot classified

versus placebo or control

No demonstrated result for efficacy

2 trialsmeta-analysis