cardiovascular prevention | versus placebo or control No demonstrated result for efficacy | 5 trials | meta-analysis | | Trial | control | p<0.05 | harm | NS |
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UCS (Dorr), 1978 | colestipol vs placebo | | | all cause deaths 0.76 [0.50; 1.15] coronary deaths 0.60 [0.34; 1.06] décès par cancer 0.98 [0.14; 6.96] cardiac death 0.60 [0.34; 1.06] non cardiovascular death 1.05 [0.52; 2.11] | Gross, 1973 | colestipol vs placebo | | | | Ryan, 1974 | colestipol vs placebo | | | | Gundersen, 1976 | colestipol vs placebo | | | | Ruoff, 1978 | colestipol vs placebo | | | all cause deaths 0.00 [0.00; NaN] coronary deaths 0.00 [0.00; NaN] cardiac death 0.00 [0.00; NaN] non cardiovascular death NaN [NaN; NaN] |
Trial | Treatments | Patients | Method |
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UCS (Dorr), 1978 | colestipol hydrochloride 32 mg/dl (n=1149) vs. placebo (n=1129)
| Hommes et femmes, > 18 ans
| double blind Parallel groups Sample size: 1149/1129 Primary endpoint: death FU duration: 1.9 years
| Gross, 1973 | colestipol (n=23) vs. placebo (n=29)
|
| Parallel groups Sample size: 23/29 Primary endpoint: FU duration: 1.0 years
| Ryan, 1974 | colestipol15 g/day (n=44) vs. placebo (n=48)
| patients with hypercholesterolemia
| Parallel groups Sample size: 44/48 Primary endpoint: FU duration: 3.0 years
| Gundersen, 1976 | colestipol 10g twice daily (n=36) vs. placebo (n=30)
| hypercholesterolemic patients
| double-blind Parallel groups Sample size: 36/30 Primary endpoint: FU duration: 0.8 years
| Ruoff, 1978 | colestipol (n=21) vs. placebo (n=19)
| hypercholesterolemic patients
| Parallel groups Sample size: 21/19 Primary endpoint: FU duration: 3.2 years
|
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