abdominal aortic aneurysm clinical trials results

doxycycline versus placebo
Mosorin, 2001
Doxycycline 150 mg/d
versus
Placebo
double blind
Follow-up duration: 18 mo
endovascular repair versus open repair
OVER, 2009
NCT00094575
endovascular repair
versus
open repair
men (aged >=49 years) with abdominal aortic aneurysms candidate for both both elective endovascular repair and open repairopen
Follow-up duration: 1.8y
USA
DREAM, 2005
NCT00421330
elective endovascular repair
versus
conventional open repair
abdominal aortic aneurysm of at least 5 cm in diameter and who were considered suitable candidates for both techniques.open
Follow-up duration: 2 y (6 y)
The Netherlands
EVAR trial 1, 2005
ISRCTN55703451
endovascular aneurysm repair
versus
open repair
aneurysms of at least 5·5 cm in diameteropen
Follow-up duration: 2.9 y (median)
UK
endovascular repair versus surveillance
PIVOTAL (Ouriel), 2010
early endovascular repair
versus
ultrasound surveillance
patients (13.3% women; mean age, 71 +/- 8 years) with 4 to 5 cm abdominal aortic aneurysms open
Follow-up duration: 20 months
USA
EVAR trial 2, 2005
ISRCTN55703451
Endovascular aneurysm repair
versus
No intervention
patients aged 60 years or older who had aneurysms of at least5·5 cm in diameter and of poor health status considered unfit for major surgery.open
Follow-up duration: 2.4 y (median)
UK
roxithromycin versus placebo
Vammen, 2001
Roxithromycin 300 mg/d
versus
Placebo
double blind
Follow-up duration: 18 mo