Aspirin antiplatelets drug  

     

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathMajor bleeding

acute coronary syndrome  

ATACS-pilot, 1990   aspirincontrolnegative
Huddinge, 1988     aspirincontrolnegative
Frankfurt, 1976   aspirincontrolnegative
VA-pilot   aspirinplacebonegative
VA-main, 1983   aspirinplaceboLow risk of bias suggesting
RISC, 1990   aspirinplaceboLow risk of bias suggesting
ALDUSA-pilot   aspirinplacebonegative
Théroux, 1988   aspirinplaceboLow risk of bias suggesting
Dutch-aspirin, 1990     aspirinplaceboLow risk of bias negative
ISIS-pilot, 1987     aspirinplaceboLow risk of bias negative-2%
ISIS-2, 1988   aspirinplaceboLow risk of bias suggesting34%
APRICOT, 1993   aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin vs PBO), 1985   aspirinplaceboLow risk of bias -
Canadian (Aspirin + sulfinpyrazone), 1985   aspirin + sulfinpyrazoneplaceboLow risk of bias negative

acute myocardial infarction  

Huddinge, 1988     aspirincontrolnegative
Frankfurt, 1976   aspirincontrolnegative
Dutch-aspirin, 1990     aspirinplaceboLow risk of bias negative
ISIS-pilot, 1987     aspirinplaceboLow risk of bias negative-2%
ISIS-2, 1988   aspirinplaceboLow risk of bias suggesting34%
APRICOT, 1993   aspirinplaceboLow risk of bias suggesting

atrial fibrillation  

LASAF(aspirin vs no treatment), 1999     aspirincontrol -
AFASAK (aspirin vs placebo), 1989   aspirinplaceboLow risk of bias negative∞%
SPAF (aspirin,warfarin ineligible arm), 1991   aspirinplaceboineligible for VKALow risk of bias negative
EAFT, 1993   aspirinplaceboLow risk of bias negative
SPAF (aspirin , warfarin eligible arm), 1991   aspirinplaceboLow risk of bias suggesting
FFAACS , 2001     aspirinplacebo (on top fluidione)Low risk of bias negative
PATAF (vs coumadin low dose), 1999     aspirincoumadin low doseRisk of bias negative
PATAF (vs coumadin standard dose), 1999     aspirincoumadin standard doseRisk of bias negative
AFASAK II (aspirin vs warfarin low dose), 1998     aspirinwarfarin low doseRisk of bias negative131%65%
SPAF II (aspirin vs warfarin standard dose, age<75), 1994   aspirinwarfarin standard doseRisk of bias negative
AFASAK II (aspirin vs warfarin standard dose), 1998     aspirinwarfarin standard doseRisk of bias negative
SPAF II (aspirin vs warfarin standard dose, age>75), 1994   aspirinwarfarin standard doseRisk of bias negative
AFASAK (aspirin vs warfarin standard dose), 1989   aspirinwarfarin standard doseRisk of bias negative

CABG surgery  

McEnany, 1982   aspirinplaceboLow risk of bias negative
Lorenz, 1984   aspirinplaceboLow risk of bias negative
GESIC (aspirin), 1990   aspirinplaceboLow risk of bias negative
Sydney, 1991   aspirinplaceboLow risk of bias -
Hockings, 1993   aspirinplaceboLow risk of bias -

cardiovascular prevention  

British Doctor’s Trial, 1988   aspirinno treatmentprimary preventionRisk of bias negative-11%
Primary Prevention Project, 2001     aspirinno treatmentprimary preventionRisk of bias negative -19%
JPAD, 2008      NCTaspirinno treatmentRisk of bias suggesting
PPP (diabetics sub group), 2003   aspirinno treatmentExploratory negative23%
CDPA, 1976   aspirinplaceboLow risk of bias negative-30%
Cardiff I, 1974   aspirinplaceboLow risk of bias negative-26%
Cardiff II, 1979   aspirinplaceboLow risk of bias negative-17%
Vogel, 1979   aspirinplaceboLow risk of bias suggesting-32%
AMIS, 1980    NCTaspirinplaceboLow risk of bias suggesting11%
GAMIS, 1980   aspirinplaceboLow risk of bias negative-18%
PARIS, 1980   aspirinplaceboLow risk of bias negative-18%
JAMIS, 1999     aspirinplacebosuggesting18%
Schoop, 1983   aspirinplaceboLow risk of bias -
Hess, 1985   aspirinplacebo -
Munich A, 1975   aspirinplaceboLow risk of bias -
Munich B, 1975   aspirinplaceboLow risk of bias -
Physicians Health Study, 1989    NCTaspirinplaceboprimary preventionLow risk of bias suggesting -4%
Thrombosis Prevention Trial, 1998        NCTaspirinplaceboprimary preventionLow risk of bias suggesting3%
HOT, 1998     aspirinplaceboprimary preventionLow risk of bias suggesting -7%
Women’s Health Study, 2005       aspirinplaceboprimary preventionLow risk of bias suggesting -5%
SAPAT, 1992   aspirinplaceboLow risk of bias suggesting
POPADAD aspirin, 2008     aspirinplaceboLow risk of bias negative-7%
DAMAD, 1989   aspirinplaceboLow risk of bias negative -51%
ETDRS, 1992   aspirinplaceboLow risk of bias suggesting-7%
CLIPS, 2007     aspirinplaceboLow risk of bias suggesting71%
AAA, 2009     aspirinplacebosecondary preventionLow risk of bias negative-5%70%
PHS (diabetics sub group), 1989   aspirinplaceboLow risk of bias suggesting
WHS (diabetics sub group), 2005   aspirinplaceboLow risk of bias suggesting
ASPREE, 2018    NCTaspirinplacebo -
ASCEND, 2018      NCTaspirinplacebosuggesting 29%

coronary artery disease  

CDPA, 1976   aspirinplaceboLow risk of bias negative-30%
Cardiff I, 1974   aspirinplaceboLow risk of bias negative-26%
Cardiff II, 1979   aspirinplaceboLow risk of bias negative-17%
Vogel, 1979   aspirinplaceboLow risk of bias suggesting-32%
AMIS, 1980    NCTaspirinplaceboLow risk of bias suggesting11%
GAMIS, 1980   aspirinplaceboLow risk of bias negative-18%
PARIS, 1980   aspirinplaceboLow risk of bias negative-18%
JAMIS, 1999     aspirinplacebosuggesting18%
SAPAT, 1992   aspirinplaceboLow risk of bias suggesting

diabetes type 2  

JPAD, 2008      NCTaspirinno treatmentRisk of bias suggesting
PPP (diabetics sub group), 2003   aspirinno treatmentExploratory negative23%
POPADAD aspirin, 2008     aspirinplaceboLow risk of bias negative-7%
DAMAD, 1989   aspirinplaceboLow risk of bias negative -51%
ETDRS, 1992   aspirinplaceboLow risk of bias suggesting-7%
PHS (diabetics sub group), 1989   aspirinplaceboLow risk of bias suggesting
WHS (diabetics sub group), 2005   aspirinplaceboLow risk of bias suggesting

heart failure  

WASH (aspirin), 2004     aspirinno treatmentnegative 40%∞%
Barzizza (ASA), 1993   aspirinplaceboExploratory -

hypertension  

HOT, 1998     aspirinplaceboprimary preventionLow risk of bias suggesting -7%

percutaneous coronary intervention  

Taylor (Perth), 1991     aspirinplaceboLow risk of bias negative
M-HEART II (aspirin), 1995     aspirinplaceboLow risk of bias negative

peripheral vascular diseases  

Lassila R, 1991   aspirincontrôle -
Schoop, 1983   aspirinplaceboLow risk of bias -
Hess, 1985   aspirinplacebo -
Munich A, 1975   aspirinplaceboLow risk of bias -
Munich B, 1975   aspirinplaceboLow risk of bias -
CLIPS, 2007     aspirinplaceboLow risk of bias suggesting71%
BOA, 2000   aspirin -

post myocardial infarction  

CDPA, 1976   aspirinplaceboLow risk of bias negative-30%
Cardiff I, 1974   aspirinplaceboLow risk of bias negative-26%
Cardiff II, 1979   aspirinplaceboLow risk of bias negative-17%
Vogel, 1979   aspirinplaceboLow risk of bias suggesting-32%
AMIS, 1980    NCTaspirinplaceboLow risk of bias suggesting11%
GAMIS, 1980   aspirinplaceboLow risk of bias negative-18%
PARIS, 1980   aspirinplaceboLow risk of bias negative-18%
JAMIS, 1999     aspirinplacebosuggesting18%

post stroke  

Canadian study (CCSG), 1978   aspirinplaceboLow risk of bias negative-21%
Swedish study , 1987   aspirinplacebonegative-8%
UK-TIA low dose , 1988   aspirinplacebonegative-10%
UK-TIA high dose , 1988   aspirinplacebosuggesting-8%
SALT , 1991   aspirinplacebonegative-11%
Reuther , 1976   aspirinplacebonegative-100%
AITA, 1975   aspirinplacebonegative-39%
DCS, 1980   aspirinplacebonegative11%
AICLA, 1981   aspirinplacebonegative9%
Lindblad , 1991   aspirinplacebosuggesting-61%
Danish low-dose, 1986   aspirinplacebonegative41%
ESPS 2 , 1996   aspirinplacebosuggesting-10%

stable angina  

SAPAT, 1992   aspirinplaceboLow risk of bias suggesting

thrombosis prevention  

Lieberman (A), 1994   IPC + aspirinaspirinnegative
Hull (+asp), 1979   IPC + aspirinaspirinnegative
Hull 2 (+asp), 1979   IPC + aspirinaspirin -
Clagett, 1975   aspirincontrolRisk of bias -
Zekert VI, 1982   aspirincontrolRisk of bias -
Gelfer, 2006   CECT + aspirinLMWH -
Pasteyer, 1977   Aspirinno treatmentExploratory negative
Rocha, 1986   Aspirinno treatmentExploratory suggesting
PEP hip-fracture, 2000     aspirinplaceboLow risk of bias suggesting 25%
MRC, 1972   aspirinplaceboLow risk of bias negative
Loew DVT, 1974   aspirinplaceboLow risk of bias -
Erfurt-A, 1979   aspirinplaceboLow risk of bias -
Zekert V, 1980   aspirinplaceboLow risk of bias -
Vinazzer I, 1980   aspirinplaceboLow risk of bias -
Vinazzer II, 1977   aspirinplaceboLow risk of bias -
PEP elective arthroplasty, 2000   aspirinplaceboLow risk of bias -
Stockholm-I, 1975   AspirinplaceboExploratory negative
Harris-I, 1977   AspirinplaceboLow risk of bias suggesting
McKenna-I, 1980   AspirinplaceboExploratory suggesting
Sautter, 1983   AspirinplaceboExploratory suggesting
McBride, 1983   AspirinplaceboExploratory negative