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Trial | Studied trt | Control trt | patients | tags | ROB | Trial result | All cause death | Major bleeding |
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ATACS-pilot, 1990 | aspirin | control | | | | negative | | |
Huddinge, 1988 | aspirin | control | | | | negative | | |
Frankfurt, 1976 | aspirin | control | | | | negative | | |
VA-pilot | aspirin | placebo | | | | negative | | |
VA-main, 1983 | aspirin | placebo | | | Low risk of bias | suggesting | | |
RISC, 1990 | aspirin | placebo | | | Low risk of bias | suggesting | | |
ALDUSA-pilot | aspirin | placebo | | | | negative | | |
Théroux, 1988 | aspirin | placebo | | | Low risk of bias | suggesting | | |
Dutch-aspirin, 1990 | aspirin | placebo | | | Low risk of bias | negative | | |
ISIS-pilot, 1987 | aspirin | placebo | | | Low risk of bias | negative | | |
ISIS-2, 1988 | aspirin | placebo | | | Low risk of bias | suggesting | | |
APRICOT, 1993 | aspirin | placebo | | | Low risk of bias | suggesting | | |
Canadian (Aspirin vs PBO), 1985 | aspirin | placebo | | | Low risk of bias | - | | |
Canadian (Aspirin + sulfinpyrazone), 1985 | aspirin + sulfinpyrazone | placebo | | | Low risk of bias | negative | | |
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Huddinge, 1988 | aspirin | control | | | | negative | | |
Frankfurt, 1976 | aspirin | control | | | | negative | | |
Dutch-aspirin, 1990 | aspirin | placebo | | | Low risk of bias | negative | | |
ISIS-pilot, 1987 | aspirin | placebo | | | Low risk of bias | negative | | |
ISIS-2, 1988 | aspirin | placebo | | | Low risk of bias | suggesting | | |
APRICOT, 1993 | aspirin | placebo | | | Low risk of bias | suggesting | | |
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LASAF(aspirin vs no treatment), 1999 | aspirin | control | | | | - | | |
AFASAK (aspirin vs placebo), 1989 | aspirin | placebo | | | Low risk of bias | negative | | |
SPAF (aspirin,warfarin ineligible arm), 1991 | aspirin | placebo | ineligible for VKA | | Low risk of bias | negative | | |
EAFT, 1993 | aspirin | placebo | | | Low risk of bias | negative | | |
SPAF (aspirin , warfarin eligible arm), 1991 | aspirin | placebo | | | Low risk of bias | suggesting | | |
FFAACS , 2001 | aspirin | placebo (on top fluidione) | | | Low risk of bias | negative | | |
PATAF (vs coumadin low dose), 1999 | aspirin | coumadin low dose | | | Risk of bias | negative | | |
PATAF (vs coumadin standard dose), 1999 | aspirin | coumadin standard dose | | | Risk of bias | negative | | |
AFASAK II (aspirin vs warfarin low dose), 1998 | aspirin | warfarin low dose | | | Risk of bias | negative | | |
SPAF II (aspirin vs warfarin standard dose, age<75), 1994 | aspirin | warfarin standard dose | | | Risk of bias | negative | | |
AFASAK II (aspirin vs warfarin standard dose), 1998 | aspirin | warfarin standard dose | | | Risk of bias | negative | | |
SPAF II (aspirin vs warfarin standard dose, age>75), 1994 | aspirin | warfarin standard dose | | | Risk of bias | negative | | |
AFASAK (aspirin vs warfarin standard dose), 1989 | aspirin | warfarin standard dose | | | Risk of bias | negative | | |
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McEnany, 1982 | aspirin | placebo | | | Low risk of bias | negative | | |
Lorenz, 1984 | aspirin | placebo | | | Low risk of bias | negative | | |
GESIC (aspirin), 1990 | aspirin | placebo | | | Low risk of bias | negative | | |
Sydney, 1991 | aspirin | placebo | | | Low risk of bias | - | | |
Hockings, 1993 | aspirin | placebo | | | Low risk of bias | - | | |
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British Doctor’s Trial, 1988 | aspirin | no treatment | primary prevention | | Risk of bias | negative | | |
Primary Prevention Project, 2001 | aspirin | no treatment | primary prevention | | Risk of bias | negative | | |
JPAD, 2008 NCT | aspirin | no treatment | | | Risk of bias | suggesting | | |
PPP (diabetics sub group), 2003 | aspirin | no treatment | | | Exploratory | negative | | |
CDPA, 1976 | aspirin | placebo | | | Low risk of bias | negative | | |
Cardiff I, 1974 | aspirin | placebo | | | Low risk of bias | negative | | |
Cardiff II, 1979 | aspirin | placebo | | | Low risk of bias | negative | | |
Vogel, 1979 | aspirin | placebo | | | Low risk of bias | suggesting | | |
AMIS, 1980 NCT | aspirin | placebo | | | Low risk of bias | suggesting | | |
GAMIS, 1980 | aspirin | placebo | | | Low risk of bias | negative | | |
PARIS, 1980 | aspirin | placebo | | | Low risk of bias | negative | | |
JAMIS, 1999 | aspirin | placebo | | | | suggesting | | |
Schoop, 1983 | aspirin | placebo | | | Low risk of bias | - | | |
Hess, 1985 | aspirin | placebo | | | | - | | |
Munich A, 1975 | aspirin | placebo | | | Low risk of bias | - | | |
Munich B, 1975 | aspirin | placebo | | | Low risk of bias | - | | |
Physicians Health Study, 1989 NCT | aspirin | placebo | primary prevention | | Low risk of bias | suggesting | | |
Thrombosis Prevention Trial, 1998 NCT | aspirin | placebo | primary prevention | | Low risk of bias | suggesting | | |
HOT, 1998 | aspirin | placebo | primary prevention | | Low risk of bias | suggesting | | |
Women’s Health Study, 2005 | aspirin | placebo | primary prevention | | Low risk of bias | suggesting | | |
SAPAT, 1992 | aspirin | placebo | | | Low risk of bias | suggesting | | |
POPADAD aspirin, 2008 | aspirin | placebo | | | Low risk of bias | negative | | |
DAMAD, 1989 | aspirin | placebo | | | Low risk of bias | negative | | |
ETDRS, 1992 | aspirin | placebo | | | Low risk of bias | suggesting | | |
CLIPS, 2007 | aspirin | placebo | | | Low risk of bias | suggesting | | |
AAA, 2009 | aspirin | placebo | secondary prevention | | Low risk of bias | negative | | |
PHS (diabetics sub group), 1989 | aspirin | placebo | | | Low risk of bias | suggesting | | |
WHS (diabetics sub group), 2005 | aspirin | placebo | | | Low risk of bias | suggesting | | |
ASPREE, 2018 NCT | aspirin | placebo | | | | - | | |
ASCEND, 2018 NCT | aspirin | placebo | | | | suggesting | | |
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CDPA, 1976 | aspirin | placebo | | | Low risk of bias | negative | | |
Cardiff I, 1974 | aspirin | placebo | | | Low risk of bias | negative | | |
Cardiff II, 1979 | aspirin | placebo | | | Low risk of bias | negative | | |
Vogel, 1979 | aspirin | placebo | | | Low risk of bias | suggesting | | |
AMIS, 1980 NCT | aspirin | placebo | | | Low risk of bias | suggesting | | |
GAMIS, 1980 | aspirin | placebo | | | Low risk of bias | negative | | |
PARIS, 1980 | aspirin | placebo | | | Low risk of bias | negative | | |
JAMIS, 1999 | aspirin | placebo | | | | suggesting | | |
SAPAT, 1992 | aspirin | placebo | | | Low risk of bias | suggesting | | |
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JPAD, 2008 NCT | aspirin | no treatment | | | Risk of bias | suggesting | | |
PPP (diabetics sub group), 2003 | aspirin | no treatment | | | Exploratory | negative | | |
POPADAD aspirin, 2008 | aspirin | placebo | | | Low risk of bias | negative | | |
DAMAD, 1989 | aspirin | placebo | | | Low risk of bias | negative | | |
ETDRS, 1992 | aspirin | placebo | | | Low risk of bias | suggesting | | |
PHS (diabetics sub group), 1989 | aspirin | placebo | | | Low risk of bias | suggesting | | |
WHS (diabetics sub group), 2005 | aspirin | placebo | | | Low risk of bias | suggesting | | |
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WASH (aspirin), 2004 | aspirin | no treatment | | | | negative | | |
Barzizza (ASA), 1993 | aspirin | placebo | | | Exploratory | - | | |
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HOT, 1998 | aspirin | placebo | primary prevention | | Low risk of bias | suggesting | | |
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Taylor (Perth), 1991 | aspirin | placebo | | | Low risk of bias | negative | | |
M-HEART II (aspirin), 1995 | aspirin | placebo | | | Low risk of bias | negative | | |
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Lassila R, 1991 | aspirin | contrôle | | | | - | | |
Schoop, 1983 | aspirin | placebo | | | Low risk of bias | - | | |
Hess, 1985 | aspirin | placebo | | | | - | | |
Munich A, 1975 | aspirin | placebo | | | Low risk of bias | - | | |
Munich B, 1975 | aspirin | placebo | | | Low risk of bias | - | | |
CLIPS, 2007 | aspirin | placebo | | | Low risk of bias | suggesting | | |
BOA, 2000 | aspirin | | | | | - | | |
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CDPA, 1976 | aspirin | placebo | | | Low risk of bias | negative | | |
Cardiff I, 1974 | aspirin | placebo | | | Low risk of bias | negative | | |
Cardiff II, 1979 | aspirin | placebo | | | Low risk of bias | negative | | |
Vogel, 1979 | aspirin | placebo | | | Low risk of bias | suggesting | | |
AMIS, 1980 NCT | aspirin | placebo | | | Low risk of bias | suggesting | | |
GAMIS, 1980 | aspirin | placebo | | | Low risk of bias | negative | | |
PARIS, 1980 | aspirin | placebo | | | Low risk of bias | negative | | |
JAMIS, 1999 | aspirin | placebo | | | | suggesting | | |
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Canadian study (CCSG), 1978 | aspirin | placebo | | | Low risk of bias | negative | | |
Swedish study , 1987 | aspirin | placebo | | | | negative | | |
UK-TIA low dose , 1988 | aspirin | placebo | | | | negative | | |
UK-TIA high dose , 1988 | aspirin | placebo | | | | suggesting | | |
SALT , 1991 | aspirin | placebo | | | | negative | | |
Reuther , 1976 | aspirin | placebo | | | | negative | | |
AITA, 1975 | aspirin | placebo | | | | negative | | |
DCS, 1980 | aspirin | placebo | | | | negative | | |
AICLA, 1981 | aspirin | placebo | | | | negative | | |
Lindblad , 1991 | aspirin | placebo | | | | suggesting | | |
Danish low-dose, 1986 | aspirin | placebo | | | | negative | | |
ESPS 2 , 1996 | aspirin | placebo | | | | suggesting | | |
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SAPAT, 1992 | aspirin | placebo | | | Low risk of bias | suggesting | | |
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Lieberman (A), 1994 | IPC + aspirin | aspirin | | | | negative | | |
Hull (+asp), 1979 | IPC + aspirin | aspirin | | | | negative | | |
Hull 2 (+asp), 1979 | IPC + aspirin | aspirin | | | | - | | |
Clagett, 1975 | aspirin | control | | | Risk of bias | - | | |
Zekert VI, 1982 | aspirin | control | | | Risk of bias | - | | |
Gelfer, 2006 | CECT + aspirin | LMWH | | | | - | | |
Pasteyer, 1977 | Aspirin | no treatment | | | Exploratory | negative | | |
Rocha, 1986 | Aspirin | no treatment | | | Exploratory | suggesting | | |
PEP hip-fracture, 2000 | aspirin | placebo | | | Low risk of bias | suggesting | | |
MRC, 1972 | aspirin | placebo | | | Low risk of bias | negative | | |
Loew DVT, 1974 | aspirin | placebo | | | Low risk of bias | - | | |
Erfurt-A, 1979 | aspirin | placebo | | | Low risk of bias | - | | |
Zekert V, 1980 | aspirin | placebo | | | Low risk of bias | - | | |
Vinazzer I, 1980 | aspirin | placebo | | | Low risk of bias | - | | |
Vinazzer II, 1977 | aspirin | placebo | | | Low risk of bias | - | | |
PEP elective arthroplasty, 2000 | aspirin | placebo | | | Low risk of bias | - | | |
Stockholm-I, 1975 | Aspirin | placebo | | | Exploratory | negative | | |
Harris-I, 1977 | Aspirin | placebo | | | Low risk of bias | suggesting | | |
McKenna-I, 1980 | Aspirin | placebo | | | Exploratory | suggesting | | |
Sautter, 1983 | Aspirin | placebo | | | Exploratory | suggesting | | |
McBride, 1983 | Aspirin | placebo | | | Exploratory | negative | | |
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