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Trial | Studied trt | Control trt | patients | tags | ROB | Trial result | All cause death | reinfarction |
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ISIS-4, 1995 | captopril | placebo | | | Low risk of bias | - | | |
CCS-1, 1995 | captopril | placebo | | | Low risk of bias | - | | |
French, 1999 | captopril | placebo | | | Low risk of bias | - | | |
CATS, 1996 | captopril | placebo | | | Low risk of bias | - | | |
ECCE, 1997 | captopril | placebo | | | Low risk of bias | - | | |
Sharpe, 1991 | captopril | placebo | | | Low risk of bias | - | | |
Ray, 1993 | captopril | placebo | | | Low risk of bias | - | | |
Nabel, 1991 | captopril | placebo | | | Low risk of bias | - | | |
Bussmann, 1992 | captopril | placebo | | | Low risk of bias | - | | |
Di Pasquale, 1994 | captopril | placebo | | | Low risk of bias | - | | |
Di Pasquale, 1997 | captopril | placebo | | | Low risk of bias | - | | |
Galcera, 1993 | captopril | placebo | | | Low risk of bias | - | | |
Hargreaves, 1992 | captopril | placebo | | | Low risk of bias | - | | |
SAVE, 1992 | captopril | placebo | | | Low risk of bias | - | | |
Pfeffer, 1988 | captopril | placebo | | | Low risk of bias | - | | |
Sogaard, 1994 | captopril | placebo | | | Low risk of bias | - | | |
Sharpe, 1988 | captopril | placebo | | | Low risk of bias | - | | |
Mortarino, 1990 | captopril | placebo | | | Low risk of bias | - | | |
PRACTICAL (captopril), 1994 | captopril or enalapril | placebo | | | Low risk of bias | - | | |
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CONSENSUS 2, 1992 | enalapril | placebo | | | Low risk of bias | - | | |
Schulman, 1995 | enalapril | placebo | | | Low risk of bias | - | | |
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FAMIS, 1998 | fosinopril | placebo | | | Low risk of bias | - | | |
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GISSI 3, 1994 | lisinopril | placebo | | | Risk of bias | - | | |
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Wagner, 2002 | ramipril | placebo | | | Low risk of bias | - | | |
AIRE, 1993 | ramipril | placebo | | | Low risk of bias | - | | |
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TRACE, 1995 | trandolapril | placebo | | | Low risk of bias | - | | |
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SMILE, 1995 | zofenopril | placebo | | | Low risk of bias | suggesting | | |
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OPTIMAAL, 2002 | Losartan | Captopril | | | Low risk of bias | suggesting | | |
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VALIANT (valsartan+capropril), 2003 | Valsartan+ACE inhibitor | ACE inhibitor only | | | Low risk of bias | negative | | |
VALIANT (valsartan alone), 2003 | Valsartan | Captopril | | | Low risk of bias | negative | | |
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Koster and Dunning, 1985 | IM lidocaine (without infusion) | control | | | Risk of bias | negative | | |
Bennett, 1970 | IV lidocaine infusion | control | | | Risk of bias | negative | | |
Pitt, 1971 | IV lidocaine infusion | control | | | Risk of bias | negative | | |
Darby, 1972 | IV lidocaine infusion | control | | | Risk of bias | negative | | |
Sandlar | IM lidocaine (without infusion) | placebo | | | Low risk of bias | negative | | |
Singh and Kocot, 1976 | IM lidocaine (without infusion) | placebo | | | Low risk of bias | negative | | |
Lie (IM), 1978 | IM lidocaine (without infusion) | placebo | | | Low risk of bias | negative | | |
Dunn, 1985 | IM lidocaine (without infusion) | placebo | | | Low risk of bias | negative | | |
Kostuk and Beanlands | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
Baker, 1971 | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
Chopra, 1971 | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
O | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
Lie (IV), 1974 | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
Wyse, 1988 | IV lidocaine infusion | placebo | | | Low risk of bias | negative | | |
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DIAMOND MI, 1997 | dofetilide | placebo | | | Low risk of bias | - | | |
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ISIS-4, 1995 | magnesium | control | | | | suggesting | | |
Wu, 1992 | magnesium | control | | | Low risk of bias | suggesting | | |
Zhu, 2002 | magnesium | control | | | | suggesting | | |
Abraham, 1987 | magnesium | placebo | | | Low risk of bias | negative | | |
MAGIC, 2000 NCT | magnesium | placebo | | | Low risk of bias | negative | | |
Bhargava, 1995 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Ceremuzynski, 1989 | magnesium | placebo | | | | suggesting | | |
Chen, 1991 | magnesium | placebo | | | | suggesting | | |
Feldstedt, 1991 | magnesium | placebo | | | Low risk of bias | negative | | |
Gyamlani, 2000 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Ising, 1990 | magnesium | placebo | | | | - | | |
Morton, 1984 | magnesium | placebo | | | Low risk of bias | negative | | |
Nakashima, 2004 | magnesium | placebo | | | Low risk of bias | negative | | |
Parikka, 1990 | magnesium | placebo | | | Low risk of bias | negative | | |
Raghu, 1999 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Rasmussen, 1986 | magnesium | placebo | | | Low risk of bias | negative | | |
Santoro, 2000 | magnesium | placebo | | | Low risk of bias | negative | | |
Shechter, 1990 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Shechter, 1991 | magnesium | placebo | | | Low risk of bias | negative | | |
Shechter, 1995 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Singh, 1990 | magnesium | placebo | | | Low risk of bias | suggesting | | |
Smith, 1986 | magnesium | placebo | | | Low risk of bias | negative | | |
Thogersen, 1995 | magnesium | placebo | | | Low risk of bias | negative | | |
Urek, 1996 | magnesium | placebo | | | Low risk of bias | negative | | |
Woods, 1992 | magnesium | placebo | | | Low risk of bias | suggesting | | |
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CAST II (early treatment), 1992 | moricizine | placebo | | | Low risk of bias | - | | |
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Sixty Plus reinfarction Study, 1980 | any anticoagulant | placebo | | | Low risk of bias | - | | |
German-Austrian Study Group (oac vs pbo), 1980 | phenprocoumon | placebo | | | Low risk of bias | negative | | |
EPSIM, 1982 | any anticoagulant | aspirin | | | | negative | | |
German-Austrian Study Group (oac vs asp), 1980 | phenprocoumon | aspirin | | | Low risk of bias | negative | | |
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ASPECT-2 (coumadin+ASA vs ASA), 2002 | coumadin | control (on top of aspirin) | | | | negative | | |
ASPECT, 1994 | coumadin | placebo | | | Low risk of bias | suggesting | | |
ASPECT-2 (coumadin alone), 2002 | coumadin | aspirin | | | | suggesting | | |
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APRICOT-2, 2002 | warfarin | control (on top of aspirin) | | | | suggesting | | |
Zibaeenezhad, 2004 | warfarin | control (on top of aspirin) | | | | negative | | |
WARIS, 1999 | warfarin | control (on top of aspirin) | | | Low risk of bias | - | | |
CHAMP, 2002 | warfarin | control (on top of aspirin) | | | | negative | | |
CARS (warafrin 3mg), 1997 | warfarin | control (on top of aspirin) | | | Low risk of bias | suggesting | | |
LoWASA, 2004 | warfarin | control (on top of aspirin) | | | Risk of bias | suggesting | | |
CARS (warfarin 1mg), 1997 | warfarin | control (on top of aspirin) | | | Low risk of bias | negative | | |
WARIS II (warfarin+ASA), 2002 | warfarin | control (on top of aspirin) | | | | suggesting | | |
Williams, 1997 | warfarin | placebo (on top of aspirin) | | | Low risk of bias | suggesting | | |
WARIS II (warfarin alone), 2002 | warfarin | aspirin | | | | suggesting | | |
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Jones, 1987 | dazoxiben | control | | | | negative | | |
GRAND, 1987 | GR3219B | control | | | | negative | | |
Gent-AMI, 1968 | misc. | control | | | | negative | | |
Johannessen, 1989 | misc. | control | | | | negative | | |
French, 1993 | flurbiprofen | placebo | | | Low risk of bias | suggesting | | |
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Huddinge, 1988 | aspirin | control | | | | negative | | |
Frankfurt, 1976 | aspirin | control | | | | negative | | |
Dutch-aspirin, 1990 | aspirin | placebo | | | Low risk of bias | negative | | |
ISIS-pilot, 1987 | aspirin | placebo | | | Low risk of bias | negative | | |
ISIS-2, 1988 | aspirin | placebo | | | Low risk of bias | suggesting | | |
APRICOT, 1993 | aspirin | placebo | | | Low risk of bias | suggesting | | |
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COMMIT, 2005 NCT | clopidogrel | placebo | | | Low risk of bias | suggesting | | |
CLARITY-TIMI 28, 2005 | clopidogrel | placebo | | | Low risk of bias | - | | |
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ERASE-MI, 2009 | elinogrel | placebo | | | Low risk of bias | negative | | |
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Dutch sulphinpyrazone, 1986 | sulfinpyrazone | control | | | | negative | | |
Wilcox, 1980 | sulfinpyrazone | placebo | | | | negative | | |
Louvain sulphinpyrazone, 1983 | sulfinpyrazone | placebo | | | Low risk of bias | negative | | |
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Knudsen-A, 1985 | ticlopidine | control | | | | negative | | |
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Sixty Plus reinfarction Study, 1980 | any anticoagulant | placebo | | | Low risk of bias | - | | |
German-Austrian Study Group (oac vs pbo), 1980 | phenprocoumon | placebo | | | Low risk of bias | negative | | |
EPSIM, 1982 | any anticoagulant | aspirin | | | | negative | | |
German-Austrian Study Group (oac vs asp), 1980 | phenprocoumon | aspirin | | | Low risk of bias | negative | | |
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ARGAMI-2, 1998 | Argatroban | heparin | | | | - | | |
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HERO, 1997 | bivalirudin | heparin | | | Low risk of bias | suggesting | | |
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ASPECT-2 (coumadin+ASA vs ASA), 2002 | coumadin | control (on top of aspirin) | | | | negative | | |
ASPECT, 1994 | coumadin | placebo | | | Low risk of bias | suggesting | | |
ASPECT-2 (coumadin alone), 2002 | coumadin | aspirin | | | | suggesting | | |
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FRAMI, 1997 | Dalteparin | placebo | | | | - | | |
BIOMACS II, 1999 | Dalteparin | placebo | | | Low risk of bias | - | | |
ASSENT Plus, 2003 | Dalteparin | UFH | | | | negative | | |
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AMI-SK, 2002 | Enoxaparin | placebo | | | Low risk of bias | - | | |
ASSENT 3, 2001 | Enoxaparin | UFH | | | | suggesting | | |
HART II, 2001 | Enoxaparin | UFH | | | | negative | | |
Baird, 2002 | Enoxaparin | UFH | | | | negative | | |
ENTIRE-TIMI 2, 2002 | Enoxaparin | UFH | | | | suggesting | | |
ASSENT 3 Plus, 2003 | Enoxaparin | UFH | | | | negative | | |
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MICHELANGELO OASIS-6, 2006 NCT | fondaparinux | placebo | | | Low risk of bias | suggesting | | |
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HIT-4, 1999 | Hirudin | heparin | | | Low risk of bias | - | | |
TIMI 9B, 1996 | Hirudin | heparin | | | Risk of bias | - | | |
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CREATE, 2005 | Reviparin | placebo | | | Low risk of bias | - | | |
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ISIS-2 Pilot, 1987 | UFH | no heparin | | | | negative | | |
DUCCS, 1994 | UFH | no heparin | | | | negative | | |
ECSG, 1992 | UFH | placebo | | | Low risk of bias | negative | | |
OSIRIS, 1992 | UFH | placebo | | | Low risk of bias | negative | | |
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APRICOT-2, 2002 | warfarin | control (on top of aspirin) | | | | suggesting | | |
Zibaeenezhad, 2004 | warfarin | control (on top of aspirin) | | | | negative | | |
WARIS, 1999 | warfarin | control (on top of aspirin) | | | Low risk of bias | - | | |
CHAMP, 2002 | warfarin | control (on top of aspirin) | | | | negative | | |
CARS (warafrin 3mg), 1997 | warfarin | control (on top of aspirin) | | | Low risk of bias | suggesting | | |
LoWASA, 2004 | warfarin | control (on top of aspirin) | | | Risk of bias | suggesting | | |
CARS (warfarin 1mg), 1997 | warfarin | control (on top of aspirin) | | | Low risk of bias | negative | | |
WARIS II (warfarin+ASA), 2002 | warfarin | control (on top of aspirin) | | | | suggesting | | |
Williams, 1997 | warfarin | placebo (on top of aspirin) | | | Low risk of bias | suggesting | | |
WARIS II (warfarin alone), 2002 | warfarin | aspirin | | | | suggesting | | |
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Julian , 1982 | Sotalol | placebo | | | Low risk of bias | |