Clinical trials in acute myocardial infarction

Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death
Group by... in first in second in third	Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Global trial result Main results All results All result tag NCT results	Numeric bar chart forest plot medians
angiotensin-Converting Enzyme Inhibitors
captopril
ISIS-4, 1995	captopril	placebo			Low risk of bias	-
CCS-1, 1995	captopril	placebo			Low risk of bias	-
French, 1999	captopril	placebo			Low risk of bias	-
CATS, 1996	captopril	placebo			Low risk of bias	-
ECCE, 1997	captopril	placebo			Low risk of bias	-
Sharpe, 1991	captopril	placebo			Low risk of bias	-
Ray, 1993	captopril	placebo			Low risk of bias	-
Nabel, 1991	captopril	placebo			Low risk of bias	-
Bussmann, 1992	captopril	placebo			Low risk of bias	-
Di Pasquale, 1994	captopril	placebo			Low risk of bias	-
Di Pasquale, 1997	captopril	placebo			Low risk of bias	-
Galcera, 1993	captopril	placebo			Low risk of bias	-
Hargreaves, 1992	captopril	placebo			Low risk of bias	-
SAVE, 1992	captopril	placebo			Low risk of bias	-
Pfeffer, 1988	captopril	placebo			Low risk of bias	-
Sogaard, 1994	captopril	placebo			Low risk of bias	-
Sharpe, 1988	captopril	placebo			Low risk of bias	-
Mortarino, 1990	captopril	placebo			Low risk of bias	-
PRACTICAL (captopril), 1994	captopril or enalapril	placebo			Low risk of bias	-
enalapril
CONSENSUS 2, 1992	enalapril	placebo			Low risk of bias	-
Schulman, 1995	enalapril	placebo			Low risk of bias	-
fosinopril
FAMIS, 1998	fosinopril	placebo			Low risk of bias	-
lisinopril
GISSI 3, 1994	lisinopril	placebo			Risk of bias	-
ramipril
Wagner, 2002	ramipril	placebo			Low risk of bias	-
AIRE, 1993	ramipril	placebo			Low risk of bias	-
trandolapril
TRACE, 1995	trandolapril	placebo			Low risk of bias	-
zofenopril
SMILE, 1995	zofenopril	placebo			Low risk of bias	suggesting
angiotensin-receptor blockers
losartan
OPTIMAAL, 2002	Losartan	Captopril			Low risk of bias	suggesting
valsartan
VALIANT (valsartan+capropril), 2003	Valsartan+ACE inhibitor	ACE inhibitor only			Low risk of bias	negative
VALIANT (valsartan alone), 2003	Valsartan	Captopril			Low risk of bias	negative
antiarrythmic drugs
not classified
Koster and Dunning, 1985	IM lidocaine (without infusion)	control			Risk of bias	negative
Bennett, 1970	IV lidocaine infusion	control			Risk of bias	negative
Pitt, 1971	IV lidocaine infusion	control			Risk of bias	negative
Darby, 1972	IV lidocaine infusion	control			Risk of bias	negative
Sandlar	IM lidocaine (without infusion)	placebo			Low risk of bias	negative
Singh and Kocot, 1976	IM lidocaine (without infusion)	placebo			Low risk of bias	negative
Lie (IM), 1978	IM lidocaine (without infusion)	placebo			Low risk of bias	negative
Dunn, 1985	IM lidocaine (without infusion)	placebo			Low risk of bias	negative
Kostuk and Beanlands	IV lidocaine infusion	placebo			Low risk of bias	negative
Baker, 1971	IV lidocaine infusion	placebo			Low risk of bias	negative
Chopra, 1971	IV lidocaine infusion	placebo			Low risk of bias	negative
O	IV lidocaine infusion	placebo			Low risk of bias	negative
Lie (IV), 1974	IV lidocaine infusion	placebo			Low risk of bias	negative
Wyse, 1988	IV lidocaine infusion	placebo			Low risk of bias	negative
dofetilide
DIAMOND MI, 1997	dofetilide	placebo			Low risk of bias	-
magnesium
ISIS-4, 1995	magnesium	control				suggesting
Wu, 1992	magnesium	control			Low risk of bias	suggesting
Zhu, 2002	magnesium	control				suggesting
Abraham, 1987	magnesium	placebo			Low risk of bias	negative
MAGIC, 2000 NCT	magnesium	placebo			Low risk of bias	negative
Bhargava, 1995	magnesium	placebo			Low risk of bias	suggesting
Ceremuzynski, 1989	magnesium	placebo				suggesting
Chen, 1991	magnesium	placebo				suggesting
Feldstedt, 1991	magnesium	placebo			Low risk of bias	negative
Gyamlani, 2000	magnesium	placebo			Low risk of bias	suggesting
Ising, 1990	magnesium	placebo				-
Morton, 1984	magnesium	placebo			Low risk of bias	negative
Nakashima, 2004	magnesium	placebo			Low risk of bias	negative
Parikka, 1990	magnesium	placebo			Low risk of bias	negative
Raghu, 1999	magnesium	placebo			Low risk of bias	suggesting
Rasmussen, 1986	magnesium	placebo			Low risk of bias	negative
Santoro, 2000	magnesium	placebo			Low risk of bias	negative
Shechter, 1990	magnesium	placebo			Low risk of bias	suggesting
Shechter, 1991	magnesium	placebo			Low risk of bias	negative
Shechter, 1995	magnesium	placebo			Low risk of bias	suggesting
Singh, 1990	magnesium	placebo			Low risk of bias	suggesting
Smith, 1986	magnesium	placebo			Low risk of bias	negative
Thogersen, 1995	magnesium	placebo			Low risk of bias	negative
Urek, 1996	magnesium	placebo			Low risk of bias	negative
Woods, 1992	magnesium	placebo			Low risk of bias	suggesting
moricizine
CAST II (early treatment), 1992	moricizine	placebo			Low risk of bias	-
anticoagulant
not classified
Sixty Plus reinfarction Study, 1980	any anticoagulant	placebo			Low risk of bias	-
German-Austrian Study Group (oac vs pbo), 1980	phenprocoumon	placebo			Low risk of bias	negative
EPSIM, 1982	any anticoagulant	aspirin				negative
German-Austrian Study Group (oac vs asp), 1980	phenprocoumon	aspirin			Low risk of bias	negative
coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002	coumadin	control (on top of aspirin)				negative
ASPECT, 1994	coumadin	placebo			Low risk of bias	suggesting
ASPECT-2 (coumadin alone), 2002	coumadin	aspirin				suggesting
warfarin
APRICOT-2, 2002	warfarin	control (on top of aspirin)				suggesting
Zibaeenezhad, 2004	warfarin	control (on top of aspirin)				negative
WARIS, 1999	warfarin	control (on top of aspirin)			Low risk of bias	-
CHAMP, 2002	warfarin	control (on top of aspirin)				negative
CARS (warafrin 3mg), 1997	warfarin	control (on top of aspirin)			Low risk of bias	suggesting
LoWASA, 2004	warfarin	control (on top of aspirin)			Risk of bias	suggesting
CARS (warfarin 1mg), 1997	warfarin	control (on top of aspirin)			Low risk of bias	negative
WARIS II (warfarin+ASA), 2002	warfarin	control (on top of aspirin)				suggesting
Williams, 1997	warfarin	placebo (on top of aspirin)			Low risk of bias	suggesting
WARIS II (warfarin alone), 2002	warfarin	aspirin				suggesting
antiplatelets drug
not classified
Jones, 1987	dazoxiben	control				negative
GRAND, 1987	GR3219B	control				negative
Gent-AMI, 1968	misc.	control				negative
Johannessen, 1989	misc.	control				negative
French, 1993	flurbiprofen	placebo			Low risk of bias	suggesting
aspirin
Huddinge, 1988	aspirin	control				negative
Frankfurt, 1976	aspirin	control				negative
Dutch-aspirin, 1990	aspirin	placebo			Low risk of bias	negative
ISIS-pilot, 1987	aspirin	placebo			Low risk of bias	negative
ISIS-2, 1988	aspirin	placebo			Low risk of bias	suggesting
APRICOT, 1993	aspirin	placebo			Low risk of bias	suggesting
clopidogrel
COMMIT, 2005 NCT	clopidogrel	placebo			Low risk of bias	suggesting
CLARITY-TIMI 28, 2005	clopidogrel	placebo			Low risk of bias	-
elinogrel
ERASE-MI, 2009	elinogrel	placebo			Low risk of bias	negative
sulfinpyrazone
Dutch sulphinpyrazone, 1986	sulfinpyrazone	control				negative
Wilcox, 1980	sulfinpyrazone	placebo				negative
Louvain sulphinpyrazone, 1983	sulfinpyrazone	placebo			Low risk of bias	negative
ticlopidine
Knudsen-A, 1985	ticlopidine	control				negative
antithrombotics
not classified
Sixty Plus reinfarction Study, 1980	any anticoagulant	placebo			Low risk of bias	-
German-Austrian Study Group (oac vs pbo), 1980	phenprocoumon	placebo			Low risk of bias	negative
EPSIM, 1982	any anticoagulant	aspirin				negative
German-Austrian Study Group (oac vs asp), 1980	phenprocoumon	aspirin			Low risk of bias	negative
argatroban
ARGAMI-2, 1998	Argatroban	heparin				-
bivalirudin
HERO, 1997	bivalirudin	heparin			Low risk of bias	suggesting
coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002	coumadin	control (on top of aspirin)				negative
ASPECT, 1994	coumadin	placebo			Low risk of bias	suggesting
ASPECT-2 (coumadin alone), 2002	coumadin	aspirin				suggesting
dalteparin
FRAMI, 1997	Dalteparin	placebo				-
BIOMACS II, 1999	Dalteparin	placebo			Low risk of bias	-
ASSENT Plus, 2003	Dalteparin	UFH				negative
enoxaparin
AMI-SK, 2002	Enoxaparin	placebo			Low risk of bias	-
ASSENT 3, 2001	Enoxaparin	UFH				suggesting
HART II, 2001	Enoxaparin	UFH				negative
Baird, 2002	Enoxaparin	UFH				negative
ENTIRE-TIMI 2, 2002	Enoxaparin	UFH				suggesting
ASSENT 3 Plus, 2003	Enoxaparin	UFH				negative
fondaparinux
MICHELANGELO OASIS-6, 2006 NCT	fondaparinux	placebo			Low risk of bias	suggesting
hirudin
HIT-4, 1999	Hirudin	heparin			Low risk of bias	-
TIMI 9B, 1996	Hirudin	heparin			Risk of bias	-
reviparin
CREATE, 2005	Reviparin	placebo			Low risk of bias	-
UFH
ISIS-2 Pilot, 1987	UFH	no heparin				negative
DUCCS, 1994	UFH	no heparin				negative
ECSG, 1992	UFH	placebo			Low risk of bias	negative
OSIRIS, 1992	UFH	placebo			Low risk of bias	negative
warfarin
APRICOT-2, 2002	warfarin	control (on top of aspirin)				suggesting
Zibaeenezhad, 2004	warfarin	control (on top of aspirin)				negative
WARIS, 1999	warfarin	control (on top of aspirin)			Low risk of bias	-
CHAMP, 2002	warfarin	control (on top of aspirin)				negative
CARS (warafrin 3mg), 1997	warfarin	control (on top of aspirin)			Low risk of bias	suggesting
LoWASA, 2004	warfarin	control (on top of aspirin)			Risk of bias	suggesting
CARS (warfarin 1mg), 1997	warfarin	control (on top of aspirin)			Low risk of bias	negative
WARIS II (warfarin+ASA), 2002	warfarin	control (on top of aspirin)				suggesting
Williams, 1997	warfarin	placebo (on top of aspirin)			Low risk of bias	suggesting
WARIS II (warfarin alone), 2002	warfarin	aspirin				suggesting
beta-blockers
not classified
Julian , 1982	Sotalol	placebo			Low risk of bias	negative
acebutolol
Azancot, 1982	Acebutolol	placebo				negative
APSI, 1990	Acebutolol	placebo			Low risk of bias	suggesting
alprenolol
Andersen , 1979	Alprenolol	placebo			Low risk of bias	negative
Wilhelmsson , 1974	Alprenolol	placebo			Low risk of bias	negative
atenolol
ISIS1 Collaborative Group , 1986	Atenolol	placebo				negative
Van de Werf , 1993	Atenolol	placebo				negative
Yusuf , 1980	Atenolol	placebo				negative
betaxolol
Yang , 1987	Betaxolol	placebo				negative
carvedilol
Basu , 1997	Carvedilol	placebo			Low risk of bias	suggesting
labetalol
Heber , 1987	Labetalol	placebo				negative
metoprolol
MIAMI Trial Research Group , 1985		placebo				negative
Von Essen , 1982		placebo				negative
TIMI IIB, 1989		placebo				negative
Hjalmarson , 1981	Metoprolol	placebo			Low risk of bias	suggesting
LIT Research Group , 1987	Metoprolol	placebo			Low risk of bias	negative
Manger Cats , 1983	Metoprolol	placebo			Low risk of bias	negative
Rehnqvist , 1983	Metoprolol	placebo			Low risk of bias	suggesting
Salathia , 1985	Metoprolol	placebo			Low risk of bias	suggesting
Waagstein , 1975	Practololormetoprolol	placebo				negative
oxprenolol
CPRG , 1981	Oxprenolol	placebo				negative
Fuccella , 1968	Oxprenolol	placebo				negative
Lombardo , 1979	Oxprenolol	placebo				negative
Wilcox , 1980	Oxprenolol	placebo				negative
EIS , 1984	Oxprenolol	placebo			Low risk of bias	negative
Schwartz (high risk and low risk) , 1992	Oxprenolol	placebo			Low risk of bias	suggesting
Taylor , 1982	Oxprenolol	placebo			Low risk of bias	negative
pindolol
Owensby , 1984	Pindolol	placebo				negative
Australian and Swedish study, 1983	Pindolol	placebo			Low risk of bias	negative
practolol
Evemy , 1978	Practolol	placebo				negative
Johansson , 1980	Practolol	placebo				negative
Macleod , 1980	Practolol	placebo				negative
Snow , 1980	Practolol	placebo				negative
Thompson , 1979	Practolol	placebo				negative
Multicentre international , 1975	Practolol	placebo			Low risk of bias	suggesting
propranolol
Aronow , 1997	Propranolol	control				suggesting
Balcon , 1966	Propranolol	placebo				negative
Barber , 1976	Propranolol	placebo				negative
Clausen , 1966	Propranolol	placebo				negative
Curtis , 1991	Propranolol	placebo				negative
Dotremont , 1968	Propranolol	placebo				negative
Gupta , 1982	Propranolol	placebo				negative
Gupta , 1984	Propranolol	placebo				negative
Hutton , 1979	Propranolol	placebo				negative
Kahler , 1968	Propranolol	placebo				negative
Ledwich , 1968	Propranolol	placebo				negative
Mueller , 1980	Propranolol	placebo				negative
Multicentre , 1966	Propranolol	placebo				negative
Nigam , 1983	Propranolol	placebo				negative
Norris , 1968	Propranolol	placebo				negative
Norris , 1978	Propranolol	placebo				negative
Norris , 1984	Propranolol	placebo				negative
Peter , 1978	Propranolol	placebo				negative
Pitt , 1976	Propranolol	placebo				negative
Roberts , 1984	Propranolol	placebo				negative
Singh , 1985	Propranolol	placebo				negative
Sloman , 1967	Propranolol	placebo				negative
Baber , 1980	Propranolol	placebo			Low risk of bias	negative
BHAT , 1982 NCT	Propranolol	placebo			Low risk of bias	suggesting
Hansteen , 1982	Propranolol	placebo			Low risk of bias	suggesting
Wilcox , 1980	Propranolol or atenolol	placebo			Low risk of bias	suggesting
sotalol
Lloyd , 1988	Sotalol	placebo				negative
timolol
Campbell , 1984	Timolol	placebo				negative
Federman , 1984	Timolol	placebo				negative
ICSG , 1984	Timolol	placebo				negative
Ranganathan , 1988	Timolol	placebo				negative
Tonkin , 1981	Timolol	placebo				negative
UKCSG , 1983	Timolol	placebo				negative
Norwegian Multicentre Study Group , 1981	Timolol	placebo			Low risk of bias	suggesting
xamoterol
McMurray , 1991	Xamoterol	placebo				negative
calcium channel blockers
not classified
Eichler, 1985	Tiapamil	control			Low risk of bias	negative
diltiazem
Machecourt, 1986	diltiazem					negative
Gibson, 1986	diltiazem	placebo			Low risk of bias	negative
MDPIT, 1988	diltiazem	placebo			Low risk of bias	negative
Zannad, 1988	diltiazem	placebo			Low risk of bias	negative
nifedipine
Muller, 1984	nifedipine				Low risk of bias	negative
Gordon, 1984	nifedipine					negative
MI study group, 1979	nifedipine					-
Eisenberg, 1985	nifedipine	placebo			Low risk of bias	negative
Bradagan, 1986	nifedipine	placebo			Low risk of bias	negative
Jaffe, 1987	nifedipine	placebo				negative
Gottlieb, 1988	nifedipine	placebo			Low risk of bias	negative
Erbel, 1988	nifedipine	placebo			Low risk of bias	negative
SPRINT I, 1988	nifedipine	placebo			Low risk of bias	negative
SPRINT II, 1993	nifedipine	placebo			Low risk of bias	negative
Loogna, 1985	nifedipine	placebo			Low risk of bias	negative
TRENT (Wilcox), 1986	nifedipine	placebo			Low risk of bias	negative
Walker, 1988	nifedipine	placebo			Low risk of bias	negative
Sirnes, 1984	nifedipine	placebo			Low risk of bias	negative
verapamil
Bussman, 1984	verapamil	control				negative
DAVIT I, 1984	verapamil	placebo			Low risk of bias	-
Crea, 1985	verapamil	placebo				negative
DAVIT II, 1990	verapamil	placebo			Low risk of bias	negative
CRIS, 1996	verapamil	placebo			Low risk of bias	negative
Danish study, 1984	verapamil	placebo			Low risk of bias	negative
cell-based therapies
not classified
MAGIC (cell infusion ), 2004	autologous bone marrow stem cells	control				-
Suarez de Lezo (cell), 2007	autologous bone marrow stem cells	control				-
TCT-STAMI (Ge), 2006	autologous bone marrow stem cells	control				negative
Huang, 2006	autologous bone marrow stem cells	control				-
MAGIC Cell-3-DES (Kang), 2006	autologous bone marrow stem cells	control				negative
Karpov, 2005	autologous bone marrow stem cells	control				-
Li, 2007	autologous bone marrow stem cells	control				-
ASTAMi (Lunde), 2006	autologous bone marrow stem cells	control				negative
Meluzin LD, 2006	autologous bone marrow stem cells	control				negative
Meluzin HD, 2006	autologous bone marrow stem cells	control				negative
BOOSt (Meyer), 2004	autologous bone marrow stem cells	control				negative
Penicka, 2007	autologous bone marrow stem cells	control				negative
Ruan, 2005	autologous bone marrow stem cells	control				-
Chen, 2004	autologous bone marrow stem cells	control				-
Suzuki, 2006	G-CSF	control				-
Deng, 2006	G-CSF	control				negative
FIRSTLINE-AMI (Ince), 2005	G-CSF	control				negative
MAGIC Cell-3-DES (Kang), 2006	G-CSF	control				negative
MAGIC (G-CSF) (Kang), 2004	G-CSF	control				negative
MAGIC 1 (Kang), 2007	G-CSF	control				negative
Takano, 2007	G-CSF	control				negative
RIGENERA (Leone), 2007	G-CSF	control				negative
Suarez de Lezo (G-CSF), 2007	G-CSF	control				negative
Janssens, 2006	autologous bone marrow stem cells	placebo			Low risk of bias	negative
REPAIR-AMI (Schachinger), 2006 NCT	autologous bone marrow stem cells	placebo			Low risk of bias	negative
REVIVAL-2 (Zohlnhöfer ), 2006 NCT	G-CSF	placebo			Low risk of bias	negative
STEMMI (Ripa), 2006	G-CSF	placebo			Low risk of bias	negative
G-CSF-STEMI (Engelmann), 2006	G-CSF	placebo			Low risk of bias	negative
Valgimigli, 2005	G-CSF	placebo			Low risk of bias	negative
Ellis, 2006 NCT	G-CSF	placebo			Low risk of bias	negative
cholesterol lowering intervention
atorvastatin
PROVE-IT, 2004	atorvastatin high dose	pravastatin	diabetic	early initiation	Low risk of bias	suggesting
complement inhibition
pexelizumab
APEX-AMI, 2007 NCT	pexelizumab	placebo			Low risk of bias	negative
COMMA, 2003	pexelizumab	placebo			Low risk of bias	negative
COMPLY, 2003	pexelizumab	placebo			Low risk of bias	negative
fibrinolysis
not classified
STAR, 1995	recombinant staphylokinase	t-PA				negative
TAMI 5 (t-PA+uroK vs tPA), 1991	t-PA + urokinase	t-PA				-
anistreplase
TEAM 2, 1991	anistreplase	streptokinase			Low risk of bias	-
APSAC
APSIM, 1989	APSAC	control				negative
AIMS, 1988	APSAC	placebo			Low risk of bias	suggesting
German Multicenter Trial, 1988	APSAC	placebo				suggesting
ISIS III (SK/APSAC), 1992	APSAC	streptokinase			Low risk of bias	negative
TEAM 3, 1992	APSAC	t-PA			Low risk of bias	-
lanoteplase
InTIME-II, 2000	lanoteplase	accelerated t-PA			Low risk of bias	negative
reteplase
GUSTO III, 1997	reteplase	accelerated t-PA				negative
RAPID-2, 1996	reteplase	accelerated t-PA			Exploratory	suggesting
INJECT, 1995	reteplase	streptokinase			Low risk of bias	negative
saruplase
COMPASS, 1998	saruplase	streptokinase			Low risk of bias	negative
PRIMI (vs SK), 1989	saruplase	streptokinase			Low risk of bias	-
SESAM, 1997	saruplase	t-PA			Exploratory	negative
PRIMI (vs UK), 1989	saruplase	urokinase			Low risk of bias	-
streptokinase
ISAM, 1986	streptokinase	placebo			Low risk of bias	negative
ISIS-2 (SK), 1988	streptokinase	placebo			Low risk of bias	suggesting
Western Washington Intravenous Trial, 1988 NCT	streptokinase	placebo				negative
GISSI I, 1986	streptokinase	placebo				suggesting
EMERAS (all delay), 1993	streptokinase	placebo			Low risk of bias	negative
ISIS 2 pilot, 1987	streptokinase	placebo			Low risk of bias	-
EMERAS (7-12h), 1993	streptokinase	placebo			Low risk of bias	-
GUSTO tPA-SK Hiv, 1993	t-PA + streptokinase	streptokinase				negative
t-pa
ASSET, 1988	t-PA	placebo			Low risk of bias	suggesting
LATE, 1993	t-PA	placebo			Low risk of bias	negative
TAMI 6, 1992	t-PA	placebo			Low risk of bias	negative
COBALT, 1997	bolus t-PA	accelerated t-PA			Low risk of bias	negative
TAPS, 1992	accelerated t-PA	APSAC				negative
TIMI 4, 1994	accelerated t-PA	APSAC			Low risk of bias	-
GUSTO tPA Hiv, 1993	accelerated t-PA	streptokinase				suggesting
GISSI II, 1990	t-PA	streptokinase				suggesting
International Study Group, 1990	t-PA	streptokinase			Low risk of bias	suggesting
ISIS III (SK/tPA), 1992	t-PA	streptokinase			Low risk of bias	suggesting
Centre Illinois, 1993	t-PA	streptokinase				-
Cherng, 1992	t-PA	streptokinase				negative
ECSG, 1985	t-PA	streptokinase				negative
PAIMS, 1989	t-PA	streptokinase				-
TIMI-1, 1987 NCT	t-PA	streptokinase			Low risk of bias	-
White, 1989	t-PA	streptokinase			Low risk of bias	-
RAAMI, 1992	accelerated t-PA	t-PA				-
KAMIT, 1991	t-PA half dose	t-PA			Exploratory	negative
TAMI 5 (t-PA vs uroK), 1991	t-PA	urokinase				-
tenecteplase
ASSENT-2, 1999	tenecteplase	accelerated t-PA			Low risk of bias	suggesting
urokinase
USIM, 1991	urokinase	control				-
glucose insulin potassium
not classified
OASIS 6, 2007 NCT	GIK infusion	control				-
CREATE-ECLA , 2006	GIK infusion	control				-
Glucose-insulin-potassium study II, 2007	GIK infusion	control				-
Krljanac, 2005	GIK infusion	control				-
Bucciarelli-Ducci , 2006	GIK infusion	placebo				-
heparin (UFH or LMWH)
enoxaparin
HART II, 2001	Enoxaparin	UFH				negative
Baird, 2002	Enoxaparin	UFH				negative
UFH
DUCCS, 1994	UFH	no heparin				negative
ECSG, 1992	UFH	placebo			Low risk of bias	negative
ICD
not classified
IRIS, 2009 NCT	early implantation of ICD after MI	control			Risk of bias	suggesting
MADIT-II, 2002	ICD	no ICD				suggesting
DINAMIT, 2004	ICD	no ICD				negative
increasing hemoglobin concentration
not classified
REVEAL NCT	erythropoietin	placebo			Low risk of bias	-
REVIVAL-3 NCT	recombinant human erythropoietin beta	placebo			Low risk of bias	-
taspoglutide
HEBE III, 2010	epoetin alfa	placebo			Exploratory	negative
Late revascularisation
PTCA
TOMIIS, 1994	late PTCA	no PTCA				negative
Horie et al, 1998	late PTCA	no PTCA				suggesting
TOAT, 2002	late PTCA	no PTCA				negative
DECOPI, 2004	late PTCA	no PTCA				negative
Silva et al, 2005	late PTCA	no PTCA				negative
OAT, 2006	late PTCA	no PTCA				negative
TOSCA-2, 2006 NCT	late PTCA	no PTCA				-
streptokinase
EMERAS (7-12h), 1993	streptokinase	placebo			Low risk of bias	-
t-pa
LATE, 1993	t-PA	placebo			Low risk of bias	negative
TAMI 6, 1992	t-PA	placebo			Low risk of bias	negative
myocardial revascularization
not classified
DANAMI, 1997	invasive strategy	concervative strategy				-
CARESS, 2008	thrombolysis + angioplasty	immediate thrombolysis				-
CAPITAL AMI, 2005	thrombolysis + angioplasty	immediate thrombolysis				suggesting
PRAGUE-1 (thrombolysis+PTCA), 2000	thrombolysis + angioplasty	immediate thrombolysis				-
NORDISTEMI, 2009 NCT	thrombolysis + angioplasty	immediate thrombolysis				suggesting
REACT (repeat fibrinolysis), 2005	repeat fibrinolysis	no repeat fibrinolysis				negative
Sarullo, 2000	repeat fibrinolysis	no repeat fibrinolysis			Low risk of bias	negative
Mounsey, 1995	repeat fibrinolysis	no repeat fibrinolysis				-
STOPAMI 1, 2000	facilitated stenting	alteplase				-
TEAHAT, 1990	Prehospital thrombolysis	at hospital thrombolysis				-
MITI, 1993 NCT	Prehospital thrombolysis	at hospital thrombolysis				negative
GREAT, 1994	Prehospital thrombolysis	at hospital thrombolysis				negative
EMIP, 1993	Prehospital thrombolysis	at hospital thrombolysis				negative
Castaigne , 1989	Prehospital thrombolysis	at hospital thrombolysis				negative
Roth, 1990	Prehospital thrombolysis	at hospital thrombolysis				negative
Schofer, 1990	Prehospital thrombolysis	at hospital thrombolysis				negative
Barbash, 1990	Prehospital thrombolysis	at hospital thrombolysis				-
Castaigne, 1987	Prehospital thrombolysis	at hospital thrombolysis				-
Mcneill, 1989	Prehospital thrombolysis	at hospital thrombolysis				-
STOPAMI 4, 2004		balloon angioplasty				negative
AIR-PAMI , 2002	transfer for primary angioplasty	immediate thrombolysis				negative
DANAMI-2 , 2003	transfer for primary angioplasty	immediate thrombolysis				negative
PRAGUE-2 , 2003	transfer for primary angioplasty	immediate thrombolysis				-
STAR, 1995	recombinant staphylokinase	t-PA				negative
TAMI 5 (t-PA+uroK vs tPA), 1991	t-PA + urokinase	t-PA				-
abciximab
BRAVE (Kastrati), 2004	Abciximab + reteplase	primary intervention				-
ERAMI (Mesquita Gabriel), 2003	Abciximab	primary intervention				negative
REOMOBILE (Arntz), 2003	Abciximab	primary intervention				negative
Zorman, 2002	Abciximab	primary intervention				negative
ReoPro-BRIDGING (Gyongyosi), 2004	Abciximab	primary intervention				negative
Bellandi, 2006	Abciximab	primary intervention				negative
FINESSE (abciximab-facilitated PCI), 2008 NCT	Abciximab	primary intervention				negative
FINESSE (combination-facilitated PCI), 2008 NCT	Abciximab + reteplase	primary intervention				negative
alteplase
LIMI (Vermeer), 1999	alteplase	primary intervention				negative
PACT (Ross,), 1999	alteplase	primary intervention				negative
anistreplase
TEAM 2, 1991	anistreplase	streptokinase			Low risk of bias	-
APSAC
APSIM, 1989	APSAC	control				negative
AIMS, 1988	APSAC	placebo			Low risk of bias	suggesting
German Multicenter Trial, 1988	APSAC	placebo				suggesting
ISIS III (SK/APSAC), 1992	APSAC	streptokinase			Low risk of bias	negative
TEAM 3, 1992	APSAC	t-PA			Low risk of bias	-
drug-eluting stents
DEDICATION, 2008 NCT	drug-eluting stents	bare-metal stent			Risk of bias	suggesting
PASEO, 2009	drug-eluting stents	bare-metal stent				-
eptifibatide
INTAMI (Zeymer), 2005	Eptifibatide	primary intervention				negative
lanoteplase
InTIME-II, 2000	lanoteplase	accelerated t-PA			Low risk of bias	negative
paclitaxel
PASSION, 2006	paclitaxel eluting stent	bare-metal stent			Risk of bias	negative
HAAMU-STENT, 2006	paclitaxel eluting stent	bare-metal stent			Exploratory	negative
HORIZONS-AMI Stent, 2008	paclitaxel eluting stent	bare-metal stent				suggesting
PCI
WEST, 2006	systematic PCI (+stent)	no systematic PCI				negative
CAPITAL AMI, 2005	systematic PCI (+stent)	no systematic PCI				negative
GRACIA-1, 2004	systematic PCI (+stent)	no systematic PCI			Risk of bias	negative
SIAM III, 2002	systematic PCI (+stent)	no systematic PCI				negative
PRAGUE, 2000	systematic PCI (+stent)	no systematic PCI				negative
C-PORT, 2002	primary PCI	accelerated t-PA				-
STAT, 2001	primary stenting	accelerated t-PA				-
Jaksch, 1998	primary stenting	balloon angioplasty				suggesting
GRAMI (Rodriguez), 1998	primary stenting	balloon angioplasty				negative
Zwolle 5 (Suryapranata), 1998	primary stenting	balloon angioplasty				suggesting
stent-PAMI (Grines), 1999	primary stenting	balloon angioplasty				suggesting
PASTA (Saito), 1999	primary stenting	balloon angioplasty				suggesting
PRISAM (Kawashima), 1999	primary stenting	balloon angioplasty				negative
STENTIM-2 (Maillard), 2000	primary stenting	balloon angioplasty				negative
PSSAAMI (Scheller), 2001	primary stenting	balloon angioplasty				suggesting
FRESCO, 1998	primary stenting	balloon angioplasty				-
CADILLAC abciximab., 2002	primary stenting	balloon angioplasty				-
CADILLAC (no abciximab), 2002	primary stenting	balloon angioplasty				-
ZWOLLE 6, 2005	primary stenting	balloon angioplasty				-
STOPAMI 3, 2004	primary stenting	balloon angioplasty				-
STOPAMI 2, 2002	primary stenting	immediate thrombolysis				-
senior PAMI, 2005 NCT	primary PCI	Thrombolysis			Risk of bias	suggesting
primary angioplasty
Ribichini, 1996	primary ballon angioplasty	accelerated t-PA				-
Garcia, 1997	primary ballon angioplasty	accelerated t-PA				-
GUSTO 2B, 1997	primary ballon angioplasty	accelerated t-PA				-
DANAMI-2, 1997	primary ballon angioplasty	accelerated t-PA				-
DeWood, 1989	primary ballon angioplasty	duteplase				-
Gibbons, 1993	primary ballon angioplasty	duteplase				-
O'Neill, 1986	primary ballon angioplasty	intracoronary streptokinase				-
Zwolle, 1994	primary ballon angioplasty	streptokinase				negative
Ribeiro, 1993	primary ballon angioplasty	streptokinase				-
Grinfeld, 1996	primary ballon angioplasty	streptokinase				-
Zijlstra, 1997	primary ballon angioplasty	streptokinase				-
Zijlstra , 1993	primary ballon angioplasty	streptokinase				-
Akhras, 1997	primary ballon angioplasty	streptokinase				-
PAMI, 1993	primary ballon angioplasty	t-PA				-
TRIANA, 2009 NCT	primary ballon angioplasty	tenecteplase			Risk of bias	negative
PTCA
MAASTRICHT (Vermeer), 1999	primary angioplasty	immediate thrombolysis				negative
PRAGUE-1, 2000	primary angioplasty	immediate thrombolysis				suggesting
AIR-PAMI, 2002	primary angioplasty	immediate thrombolysis				negative
CAPTIM, 2002	primary angioplasty	immediate thrombolysis				negative
DANAMI-2, 2003	primary angioplasty	immediate thrombolysis				suggesting
PRAGUE-2, 2003	primary angioplasty	immediate thrombolysis				suggesting
TAMI 1 pilot, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	suggesting
ECSG, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	negative
TAMI-5 (Califf), 1991	immediate systematic ballon angioplastyte	no immediate angioplasty				-
SHOCK (Hochman), 1999 NCT	immediate systematic ballon angioplastyte	no immediate angioplasty			Risk of bias	suggesting
Ellis, 1994	immediate systematic ballon angioplastyte	no immediate angioplasty				-
Erbel, 1989	immediate systematic ballon angioplastyte	no immediate angioplasty				-
MERLIN (Sutton), 2004	immediate systematic ballon angioplastyte	no immediate angioplasty				-
SWISS-SMASH, 1999	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	negative
TIMI 2A, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
Belenkie, 1991	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
Topol, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
TOMIIS, 1994	late PTCA	no PTCA				negative
Horie et al, 1998	late PTCA	no PTCA				suggesting
TOAT, 2002	late PTCA	no PTCA				negative
DECOPI, 2004	late PTCA	no PTCA				negative
Silva et al, 2005	late PTCA	no PTCA				negative
OAT, 2006	late PTCA	no PTCA				negative
TOSCA-2, 2006 NCT	late PTCA	no PTCA				-
REACT (rescue PCI), 2005	rescue PTCA	no rescue PTCA				suggesting
MERLIN, 2004	rescue PTCA	no rescue PTCA				negative
RESCUE II, 2000	rescue PTCA	no rescue PTCA				negative
RESCUE, 1994	rescue PTCA	no rescue PTCA				negative
Belenkie, 1992	rescue PTCA	no rescue PTCA			Risk of bias	negative
SWIFT, 1991	systematic ballon angioplasty	no systematic angioplasty			Risk of bias	negative
SIAM, 1992	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
TIMI 2, 1989	systematic ballon angioplasty	no systematic angioplasty			Risk of bias	negative
Guerci, 1987	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
Van den Brand, 1991	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
TOPS, 1992	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
TIMI II-A (defered)	systematic ballon angioplasty	no systematic angioplasty				-
Vermeer, 1999	systematic ballon angioplasty	no systematic angioplasty				-
TAMI 6, 1992	systematic ballon angioplasty	no systematic angioplasty				-
Barbash, 1990	systematic ballon angioplasty	no systematic angioplasty				-
reteplase
GUSTO III, 1997	reteplase	accelerated t-PA				negative
RAPID-2, 1996	reteplase	accelerated t-PA			Exploratory	suggesting
INJECT, 1995	reteplase	streptokinase			Low risk of bias	negative
saruplase
COMPASS, 1998	saruplase	streptokinase			Low risk of bias	negative
PRIMI (vs SK), 1989	saruplase	streptokinase			Low risk of bias	-
SESAM, 1997	saruplase	t-PA			Exploratory	negative
PRIMI (vs UK), 1989	saruplase	urokinase			Low risk of bias	-
sirolimus eluting stent
TYPHOON, 2006 NCT	sirolimus eluting stent	bare-metal stent				suggesting
SESAMI, 2007 NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
MISSION, 2008	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
Díaz de la Llera, 2007	sirolimus eluting stent	bare-metal stent				-
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
Juwana, 2009	sirolimus eluting stent	paclitaxel eluting stent				negative
streptokinase
ISAM, 1986	streptokinase	placebo			Low risk of bias	negative
ISIS-2 (SK), 1988	streptokinase	placebo			Low risk of bias	suggesting
Western Washington Intravenous Trial, 1988 NCT	streptokinase	placebo				negative
GISSI I, 1986	streptokinase	placebo				suggesting
EMERAS (all delay), 1993	streptokinase	placebo			Low risk of bias	negative
ISIS 2 pilot, 1987	streptokinase	placebo			Low risk of bias	-
EMERAS (7-12h), 1993	streptokinase	placebo			Low risk of bias	-
SAMI (O’Neill), 1992	streptokinase	primary intervention				negative
PRAGUE (Widimisky), 2000	streptokinase	primary intervention				negative
GUSTO tPA-SK Hiv, 1993	t-PA + streptokinase	streptokinase				negative
t-pa
ASSET, 1988	t-PA	placebo			Low risk of bias	suggesting
LATE, 1993	t-PA	placebo			Low risk of bias	negative
TAMI 6, 1992	t-PA	placebo			Low risk of bias	negative
COBALT, 1997	bolus t-PA	accelerated t-PA			Low risk of bias	negative
TAPS, 1992	accelerated t-PA	APSAC				negative
TIMI 4, 1994	accelerated t-PA	APSAC			Low risk of bias	-
GUSTO tPA Hiv, 1993	accelerated t-PA	streptokinase				suggesting
GISSI II, 1990	t-PA	streptokinase				suggesting
International Study Group, 1990	t-PA	streptokinase			Low risk of bias	suggesting
ISIS III (SK/tPA), 1992	t-PA	streptokinase			Low risk of bias	suggesting
Centre Illinois, 1993	t-PA	streptokinase				-
Cherng, 1992	t-PA	streptokinase				negative
ECSG, 1985	t-PA	streptokinase				negative
PAIMS, 1989	t-PA	streptokinase				-
TIMI-1, 1987 NCT	t-PA	streptokinase			Low risk of bias	-
White, 1989	t-PA	streptokinase			Low risk of bias	-
RAAMI, 1992	accelerated t-PA	t-PA				-
KAMIT, 1991	t-PA half dose	t-PA			Exploratory	negative
TAMI 5 (t-PA vs uroK), 1991	t-PA	urokinase				-
tenecteplase
ADVANCE-MI, 2005	Eptifibatide + tenecteplase	primary intervention				-
ASSENT-2, 1999	tenecteplase	accelerated t-PA			Low risk of bias	suggesting
ASSENT-4 PCI (Van de Werf), 2006 NCT		primary intervention				negative
GRACIA (Fernandez-Aviles,), 2004	tenecteplase	primary intervention				negative
tirofiban
On-Time (van’t Hof), 2004	Tirofiban	primary intervention				negative
TIGER-PA (Lee), 2003	Tirofiban	primary intervention				negative
Cutlip, 2003	Tirofiban	primary intervention				negative
urokinase
USIM, 1991	urokinase	control				-
zotarolimus eluting stent
ZEST AMI (vs PES), 2009 NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ZEST AMI (vs SES), 2009 NCT	zotarolimus eluting stent	sirolimus eluting stent				negative
nitrates
not classified
Hockings, 1981	nitroprusside	control			Exploratory	negative
Zharov, 1991	error	error			Exploratory	-
Durrer, 1982	nitroprusside	placebo			Risk of bias	suggesting
Cohn, 1982	nitroprusside	placebo			Low risk of bias	negative
isosorbide dinitrate
Hildebrandt, 1992	isosorbide dinitrate	placebo			Low risk of bias	negative
ISIS-4, 1995	isosorbide mononitrate	placebo			Low risk of bias	suggesting
Hargreaves, 1992	isosorbide mononitrate	placebo			Low risk of bias	negative
Fitzgerald, 1990	isosorbide mononitrate	placebo			Low risk of bias	negative
molsidomine
ESPRIM, 1994	molsidomine	placebo			Low risk of bias	negative
Beaufils, 1988	molsidomine	placebo			Low risk of bias	negative
nitroglycerin
Chiche, 1979	nitroglycerin	control			Risk of bias	negative
Bussman, 1981	nitroglycerin	control			Exploratory	suggesting
Nelson, 1983	nitroglycerin	control			Risk of bias	negative
Jugdutt, 1983	nitroglycerin	control			Exploratory	suggesting
GISSI-3, 1994	nitroglycerin	control			Risk of bias	suggesting
Jugdutt, 1988	nitroglycerin	control			Exploratory	suggesting
Flaherty, 1983	nitroglycerin	placebo			Risk of bias	negative
Jaffe, 1983	nitroglycerin	placebo			Low risk of bias	negative
Lis, 1984	nitroglycerin	placebo			Low risk of bias	negative
Charvat, 1990	nitroglycerin	placebo			Low risk of bias	negative
oxygen therapy
not classified
Dekleva, 2004	error	control				negative
Sharifi, 2004	hyperbaric oxygen	control				suggesting
Swift, 1992	hyperbaric oxygen	control				-
Thurston, 1973	hyperbaric oxygen	control				suggesting
Hot MI, 1997	hyperbaric oxygen	control				negative
HOT MI pilot, 1997	Hyperbaric oxygen	control				-
Rawles, 1976	oxygen therapy	control				negative
Wilson, 1997	oxygen therapy	control				negative
Ukholkina, 2005	oxygen therapy	control				negative
AMIHOT, 2007	supersaturated oxygen	control				-
AMIHOT II , 2000 NCT	supersaturated oxygen	control				-
Kerr, 1975	Entonox	placebo			Low risk of bias	-
PCI
not classified
DANAMI, 1997	invasive strategy	concervative strategy				-
CARESS, 2008	thrombolysis + angioplasty	immediate thrombolysis				-
CAPITAL AMI, 2005	thrombolysis + angioplasty	immediate thrombolysis				suggesting
PRAGUE-1 (thrombolysis+PTCA), 2000	thrombolysis + angioplasty	immediate thrombolysis				-
NORDISTEMI, 2009 NCT	thrombolysis + angioplasty	immediate thrombolysis				suggesting
REACT (repeat fibrinolysis), 2005	repeat fibrinolysis	no repeat fibrinolysis				negative
Sarullo, 2000	repeat fibrinolysis	no repeat fibrinolysis			Low risk of bias	negative
Mounsey, 1995	repeat fibrinolysis	no repeat fibrinolysis				-
STOPAMI 1, 2000	facilitated stenting	alteplase				-
STOPAMI 4, 2004		balloon angioplasty				negative
AIR-PAMI , 2002	transfer for primary angioplasty	immediate thrombolysis				negative
DANAMI-2 , 2003	transfer for primary angioplasty	immediate thrombolysis				negative
PRAGUE-2 , 2003	transfer for primary angioplasty	immediate thrombolysis				-
drug-eluting stents
DEDICATION, 2008 NCT	drug-eluting stents	bare-metal stent			Risk of bias	suggesting
PASEO, 2009	drug-eluting stents	bare-metal stent				-
paclitaxel
PASSION, 2006	paclitaxel eluting stent	bare-metal stent			Risk of bias	negative
HAAMU-STENT, 2006	paclitaxel eluting stent	bare-metal stent			Exploratory	negative
HORIZONS-AMI Stent, 2008	paclitaxel eluting stent	bare-metal stent				suggesting
PCI
WEST, 2006	systematic PCI (+stent)	no systematic PCI				negative
CAPITAL AMI, 2005	systematic PCI (+stent)	no systematic PCI				negative
GRACIA-1, 2004	systematic PCI (+stent)	no systematic PCI			Risk of bias	negative
SIAM III, 2002	systematic PCI (+stent)	no systematic PCI				negative
PRAGUE, 2000	systematic PCI (+stent)	no systematic PCI				negative
C-PORT, 2002	primary PCI	accelerated t-PA				-
STAT, 2001	primary stenting	accelerated t-PA				-
Jaksch, 1998	primary stenting	balloon angioplasty				suggesting
GRAMI (Rodriguez), 1998	primary stenting	balloon angioplasty				negative
Zwolle 5 (Suryapranata), 1998	primary stenting	balloon angioplasty				suggesting
stent-PAMI (Grines), 1999	primary stenting	balloon angioplasty				suggesting
PASTA (Saito), 1999	primary stenting	balloon angioplasty				suggesting
PRISAM (Kawashima), 1999	primary stenting	balloon angioplasty				negative
STENTIM-2 (Maillard), 2000	primary stenting	balloon angioplasty				negative
PSSAAMI (Scheller), 2001	primary stenting	balloon angioplasty				suggesting
FRESCO, 1998	primary stenting	balloon angioplasty				-
CADILLAC abciximab., 2002	primary stenting	balloon angioplasty				-
CADILLAC (no abciximab), 2002	primary stenting	balloon angioplasty				-
ZWOLLE 6, 2005	primary stenting	balloon angioplasty				-
STOPAMI 3, 2004	primary stenting	balloon angioplasty				-
STOPAMI 2, 2002	primary stenting	immediate thrombolysis				-
senior PAMI, 2005 NCT	primary PCI	Thrombolysis			Risk of bias	suggesting
primary angioplasty
Ribichini, 1996	primary ballon angioplasty	accelerated t-PA				-
Garcia, 1997	primary ballon angioplasty	accelerated t-PA				-
GUSTO 2B, 1997	primary ballon angioplasty	accelerated t-PA				-
DANAMI-2, 1997	primary ballon angioplasty	accelerated t-PA				-
DeWood, 1989	primary ballon angioplasty	duteplase				-
Gibbons, 1993	primary ballon angioplasty	duteplase				-
O'Neill, 1986	primary ballon angioplasty	intracoronary streptokinase				-
Zwolle, 1994	primary ballon angioplasty	streptokinase				negative
Ribeiro, 1993	primary ballon angioplasty	streptokinase				-
Grinfeld, 1996	primary ballon angioplasty	streptokinase				-
Zijlstra, 1997	primary ballon angioplasty	streptokinase				-
Zijlstra , 1993	primary ballon angioplasty	streptokinase				-
Akhras, 1997	primary ballon angioplasty	streptokinase				-
PAMI, 1993	primary ballon angioplasty	t-PA				-
TRIANA, 2009 NCT	primary ballon angioplasty	tenecteplase			Risk of bias	negative
PTCA
MAASTRICHT (Vermeer), 1999	primary angioplasty	immediate thrombolysis				negative
PRAGUE-1, 2000	primary angioplasty	immediate thrombolysis				suggesting
AIR-PAMI, 2002	primary angioplasty	immediate thrombolysis				negative
CAPTIM, 2002	primary angioplasty	immediate thrombolysis				negative
DANAMI-2, 2003	primary angioplasty	immediate thrombolysis				suggesting
PRAGUE-2, 2003	primary angioplasty	immediate thrombolysis				suggesting
TAMI 1 pilot, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	suggesting
ECSG, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	negative
TAMI-5 (Califf), 1991	immediate systematic ballon angioplastyte	no immediate angioplasty				-
Ellis, 1994	immediate systematic ballon angioplastyte	no immediate angioplasty				-
Erbel, 1989	immediate systematic ballon angioplastyte	no immediate angioplasty				-
MERLIN (Sutton), 2004	immediate systematic ballon angioplastyte	no immediate angioplasty				-
SWISS-SMASH, 1999	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	negative
TIMI 2A, 1988	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
Belenkie, 1991	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
Topol, 1987	immediate systematic ballon angioplastyte	no immediate angioplasty			Exploratory	-
REACT (rescue PCI), 2005	rescue PTCA	no rescue PTCA				suggesting
MERLIN, 2004	rescue PTCA	no rescue PTCA				negative
RESCUE II, 2000	rescue PTCA	no rescue PTCA				negative
RESCUE, 1994	rescue PTCA	no rescue PTCA				negative
Belenkie, 1992	rescue PTCA	no rescue PTCA			Risk of bias	negative
SWIFT, 1991	systematic ballon angioplasty	no systematic angioplasty			Risk of bias	negative
SIAM, 1992	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
TIMI 2, 1989	systematic ballon angioplasty	no systematic angioplasty			Risk of bias	negative
Guerci, 1987	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
Van den Brand, 1991	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
TOPS, 1992	systematic ballon angioplasty	no systematic angioplasty			Exploratory	negative
TIMI II-A (defered)	systematic ballon angioplasty	no systematic angioplasty				-
Vermeer, 1999	systematic ballon angioplasty	no systematic angioplasty				-
TAMI 6, 1992	systematic ballon angioplasty	no systematic angioplasty				-
Barbash, 1990	systematic ballon angioplasty	no systematic angioplasty				-
sirolimus eluting stent
TYPHOON, 2006 NCT	sirolimus eluting stent	bare-metal stent				suggesting
SESAMI, 2007 NCT	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
MISSION, 2008	sirolimus eluting stent	bare-metal stent			Risk of bias	suggesting
Díaz de la Llera, 2007	sirolimus eluting stent	bare-metal stent				-
DEBATER (SES vs BMS), 2009	sirolimus eluting stent	bare-metal stent				suggesting
PROSIT, 2006	sirolimus eluting stent	paclitaxel eluting stent				negative
Di Lorenzo et al., 2005	sirolimus eluting stent	paclitaxel eluting stent				negative
Juwana, 2009	sirolimus eluting stent	paclitaxel eluting stent				negative
zotarolimus eluting stent
ZEST AMI (vs PES), 2009 NCT	zotarolimus eluting stent	paclitaxel eluting stent			Risk of bias	negative
ZEST AMI (vs SES), 2009 NCT	zotarolimus eluting stent	sirolimus eluting stent				negative
percutaneous left ventricular assist device
not classified
Arias, 2005	IABP	non-IABP			Exploratory	negative
IABP SHOCK II, 2012 NCT	IABP	non-IABP			Risk of bias	negative
TACTICS, 2005	IABP	non-IABP			Risk of bias	negative
IABP SHOCK (Prondzinsky), 2010 NCT	IABP	non-IABP			Risk of bias	negative
Burkhoff, 2006	IABP	other LVAD			Exploratory	negative
Seyfarth, 2008	IABP	other LVAD			Exploratory	negative
Thiele, 2005	IABP	other LVAD			Exploratory	negative
percutaneous left ventricular assist devices
not classified
Seyfarth, 2008	Impella LP2.5	intra-aortic balloon pump				negative
Burkhoff, 2006	TandemHeart	intra-aortic balloon pump				negative
Thiele, 2005	TandemHeart	intra-aortic balloon pump				negative
thrombectomy
not classified
Wang, 2003	Angioguard	conventional PCI				-
DIPLOMATE, 2004	Angioguard	conventional PCI				negative
AiMI, 2006	AngioJet	conventional PCI				negative
Florence, 2004	AngioJet	conventional PCI				negative
JETSTENT, 2010	AnjioJet	conventional PCI			Exploratory	negative
Export (Chevalier), 2008	Export	conventional PCI				suggesting
EXPIRA, 2005	Export	conventional PCI				negative
Noel, 2005	Export	conventional PCI				negative
TAPAS, 2008	Export	conventional PCI				suggesting
Lipiecki, 2009	Export	conventional PCI				-
PROMISE, 2005	FilterWire	conventional PCI				-
UpFlow MI, 2007	FilterWire	conventional PCI				negative
DEDICATION, 2008	FilterWireg	conventional PCI				negative
ASPARAGUS, 2008	Guardwire	conventional PCI				negative
Nanasato, 2004	Guardwire	conventional PCI				-
EMERALD, 2005	GuardWire	conventional PCI				negative
Ochala, 2007	GuardWire	conventional PCI				negative
MICADO, 2007	GuardWire	conventional PCI				negative
Tahk, 2008	GuardWire	conventional PCI				suggesting
DEAR-MI, 2006 NCT	Pronto	conventional PCI				suggesting
NONSTOP, 2004	Rescue	conventional PCI				-
Dudek, 2004	Rescue	conventional PCI				suggesting
Kaltoft, 2006	Rescue	conventional PCI				negative
PREMIAR, 2007	SpideRX	conventional PCI				negative
Ciszewski, 2011	thrombectomy	conventional PCI				-
TROPHI	thrombectomy	conventional PCI				-
Chao, 2008	thrombectomy	conventional PCI				-
INFUSE AMI, 2013	thrombectomy	conventional PCI				-
Liistro, 2009	thrombectomy	conventional PCI				-
VAMPIRE, 2004	TVAC	conventional PCI				suggesting
Napodano, 2003	X-sizer	conventional PCI				suggesting
X AMINE ST, 2005	X-sizer	conventional PCI				suggesting
Beran, 2002	X-sizer	conventional PCI				suggesting
TASTE (Fröbert), 2013 NCT	thrombectomy	PCI only				-
TOTAL, 2015 NCT	thrombectomy	PCI only	aaa			negative
divers
PIHRATE, 2004	Diver	conventional PCI				negative
REMEDIA, 2005	Diver	conventional PCI				suggesting
De Luca, 2006	Diver	conventional PCI				suggesting
Sardella, 2005	Diver	conventional PCI				-

acute myocardial infarction systematic review meta-analysis network meta-analysis

Group by...

acute myocardial infarction
systematic review meta-analysis network meta-analysis