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acute coronary syndrome
acute myocardial infarction
percutaneous coronary intervention
pulmonary embolism
superficial thrombophlebitis
thrombosis prevention
venous thrombosis
fondaparinux
indirect anti-XA
pentasccharide
synthetic oligosaccharide
vs placebo or control
vs heparin/VKA
vs LMWH
vs Low molecular weight heparin
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Description
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Characteristics
Method
Risk of bias
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Global trial result
Main results
All results
All result tag
NCT results
Major bleeding (23)
All cause death (21)
Venous thromboembolism (18)
fatal pulmonary embolism (17)
Deep vein thrombosis (16)
Symptomatic deep-vein thrombosis (16)
Symptomatic pulmonary embolism (15)
Symptomatic venous thromboembolism (DVT, PE) (15)
non-fatal pulmonary embolism (15)
proximal DVT (13)
Minor bleeding (6)
myocardial infarction (fatal and non fatal) (4)
net benefit (3)
major or clinically relevant non-major bleeding (3)
myocardial infarction or death (2)
recurrent angina (2)
death, myocardial infarction, or recurrent at 14 days (2)
death, myocardial infarction, or recurrent at 30 days (2)
death at 30 days (2)
myocardial infarction at 30 days (2)
stroke (fatal and non fatal) (2)
Drop in platelet count of 50% (2)
Revascularization (2)
asymptomatic DVT (2)
pulmonary embolism (symptomatic and asymptomatic) (2)
proximal deep-vein thrombosis (2)
Venous thromboembolism or death (2)
Bleeding (2)
VTE (2)
death, MI, unplanned revascularization (2)
total VTE and all-cause mortality (2)
recurrent DVT (1)
major bleeding TIMI (1)
TIMI minor bleeding (1)
Cardiovascular death (1)
all cause death, MI, stroke (1)
Urgent target-vessel revascularization (1)
Stent thrombosis (any, end of follow up) (1)
Major or minor TIMI bleeding (1)
cardiovascular events (1)
any bleedings (1)
Fatal bleeding (1)
Venous thromboembolism end of treatment (1)
Extension and/or recurrence of SVT (1)
Heparin-induced thrombocytopenia (1)
Pain disappearance (1)
reinfarction (1)
In-hospital death (1)
reinfarction at 30 days (1)
death at 30 days (1)
Deaths or MI (1)
MACE (1)
ischemic events + bleeding (1)
Unplanned revascularisation for ischaemia (1)
recurrent VTE during treatment (1)
symptomatic pulmonary embolism (1)
Death related to venous thromboembolism (1)
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medians
Trial
Studied trt
Control trt
patients
tags
ROB
Trial result
Major bleeding
All cause death
acute coronary syndrome
PENTUA, 2004
fondaparinux
enoxaparin
-
OASIS 5, 2006
NCT
fondaparinux
enoxaparin
Low risk of bias
-
acute myocardial infarction
MICHELANGELO OASIS-6, 2006
NCT
fondaparinux
placebo
Low risk of bias
suggesting
-17%
pulmonary embolism
MATISSE PE, 2003
fondaparinux
heparin
Risk of bias
negative
-15%
19%
superficial thrombophlebitis
CALISTO, 2010
NCT
fondaparinux
placebo
Low risk of bias
suggesting
thrombosis prevention
ARTEMIS (Cohen), 2006
fondaparinux
placebo
medical patients
Low risk of bias
negative
-3%
-100%
DRI4757
fondaparinux
placebo
knee surgery
Low risk of bias
-
APOLLO (Turpie), 2007
fondaparinux
placebo (on top intermittent pneumatic comp.)
abdominal surgery
Low risk of bias
suggesting
924%
-49%
PENTAMAKS (Bauer), 2001
fondaparinux
enoxaparin
knee surgery
Low risk of bias
suggesting
1000%
-33%
PENTHIFRA (Eriksson), 2001
fondaparinux
enoxaparin
hip surgery
Low risk of bias
suggesting
-4%
-30%
PENTATHLON (Turpie), 2002
fondaparinux
enoxaparin
hip surgery
Low risk of bias
suggesting
82%
200%
EPHESUS (Lassen), 2002
fondaparinux
enoxaparin
hip surgery
Low risk of bias
suggesting
51%
-100%
Turpie, 2001
fondaparinux
enoxaparin
hip surgery
Low risk of bias
-
PEGASUS, 2005
fondaparinux
enoxaparin
abdominal surgery
Low risk of bias
negative
39%
-25%
BRiEF
NCT
fondaparinux
enoxaparin
medical patients
-
L8541
fondaparinux
enoxaparin
orthopaedic surgery
Low risk of bias
negative
-8%
L8635
fondaparinux
enoxaparin
knee surgery
Exploratory
negative
venous thrombosis
MATISSE, 2004
fondaparinux
enoxaparin
Low risk of bias
negative
9%
25%
MATISSE PE, 2003
fondaparinux
heparin
Risk of bias
negative
-15%
19%
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