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Trial | Studied trt | Control trt | patients | tags | ROB | Trial result | Major bleeding | All cause death |
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APPRAISE-1 (10mg od), 2009 NCT | apixaban | placebo | | | Low risk of bias | negative | | |
APPRAISE-1 (2.5 mg bid), 2009 NCT | apixaban | placebo | | | Low risk of bias | negative | | |
APPRAISE 2, 2011 NCT | apixaban | placebo | | | Low risk of bias | negative | | |
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ARGAMI-2, 1998 | Argatroban | heparin | | | | - | | |
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ATACS-pilot, 1990 | aspirin | control | | | | negative | | |
VA-pilot | aspirin | placebo | | | | negative | | |
VA-main, 1983 | aspirin | placebo | | | Low risk of bias | suggesting | | |
RISC, 1990 | aspirin | placebo | | | Low risk of bias | suggesting | | |
ALDUSA-pilot | aspirin | placebo | | | | negative | | |
Théroux, 1988 | aspirin | placebo | | | Low risk of bias | suggesting | | |
Canadian (Aspirin vs PBO), 1985 | aspirin | placebo | | | Low risk of bias | - | | |
Canadian (Aspirin + sulfinpyrazone), 1985 | aspirin + sulfinpyrazone | placebo | | | Low risk of bias | negative | | |
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LANCELOT ACS | atopaxar | placebo | | | Exploratory | - | | |
J-LANCELOT, 2010 | atopaxar | placebo | | | Exploratory | - | | |
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ACUITY (biva alone vs hep+aGP2b3a), 2006 NCT | bivalirudin | heparin + GP2b3a inhibitors | | | Low risk of bias | suggesting | | |
ACUITY (biva+aGP2b3a vs hep+aGP2b3a), 2006 NCT | bivalirudin + GP2b3a inhibitors | heparin + GP2b3a inhibitors | | | Low risk of bias | negative | | |
PROTECT-TIMI 30, 2006 NCT | bivalirudin | eptifibatide + heparin | | | Exploratory | - | | |
HERO, 1997 | bivalirudin | heparin | | | Low risk of bias | suggesting | | |
BAT (Bittl), 1995 | bivalirudin | heparin | | | Low risk of bias | suggesting | | |
ACUITY (sub groups PCI, bivalirudin alone) importé, 2007 | bivalirudin | heparin + GP2b3a inhibitors | | | | suggesting | | |
ACUITY (sub groups PCI, bivalirudin +aGP2b3a) importé, 2007 | bivalirudin + GP2b3a inhibitors | heparin + GP2b3a inhibitors | | | | negative | | |
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CURE (PCI sub study), 2001 | clopidogrel | placebo | | | Low risk of bias | - | | |
CURE, 2001 | clopidogrel + aspirin | aspirin | | | Low risk of bias | suggesting | | |
CURRENT OASIS 7 (clopidogrel), 2010 NCT | clopidogrel high-dose regimen | clopidogrel standard-dose | | | Low risk of bias | negative | | |
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ASPECT-2 (coumadin+asp vs asp), 2002 | coumadin | control (on top of aspirin) | | | | suggesting | | |
ASPECT-2 (coumadin vs aspirin), 2002 | coumadin | aspirin | | | | suggesting | | |
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FRISC (long term), 1996 | dalteparin | placebo (on top of aspirin) | | | Low risk of bias | suggesting | | |
FRIC prolonged treatment phase (LWMH vs PBO), 1997 | dalteparin | placebo (on top of aspirin) | | | Low risk of bias | negative | | |
FRISC (short term), 1996 | dalteparin | placebo (on top of aspirin) | | | Low risk of bias | - | | |
FRIC (acute phase LMWH vs UFH), 1997 | dalteparin | UFH (on top of aspirin) | | | Exploratory | negative | | |
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Prandoni, 1991 | aspirin + dipyridamol | placebo | | | Low risk of bias | negative | | |
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Klootwijk, 1999 | Efegatran | heparin | | | Exploratory | - | | |
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RESCUE NCT | enoxaparin | unfractionated heparin | | | | - | | |
EVET, 2005 | enoxaparin | tinzaparin | | | | suggesting | | |
ESSENCE, 1997 | enoxaparin | UFH (on top of aspirin) | | | Low risk of bias | suggesting | | |
TIMI 11 B (short term), 1998 | enoxaparin | UFH (on top of aspirin) | | | Low risk of bias | suggesting | | |
SYNERGY, 2005 NCT | enoxaparin | UFH (on top of aspirin) | | | | negative | | |
INTERACT, 2006 | enoxaparin | UFH (on top of aspirin) | | | | suggesting | | |
TIMI 11 B (long term), 1998 | enoxaparin | UFH (on top of aspirin) | | | Low risk of bias | negative | | |
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PENTUA, 2004 | fondaparinux | enoxaparin | | | | - | | |
OASIS 5, 2006 NCT | fondaparinux | enoxaparin | | | Low risk of bias | - | | |
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HIT-4, 1999 | Hirudin | heparin | | | Low risk of bias | - | | |
TIMI 9B, 1996 | Hirudin | heparin | | | Risk of bias | - | | |
GUSTO IIB, 1996 | Hirudin | heparin | | | Risk of bias | - | | |
OASIS pilot, 1997 | Hirudin | heparin | | | Exploratory | - | | |
HELVETICA (Serruys), 1995 | Hirudin | heparin | | | Low risk of bias | - | | |
OASIS 2, 1999 | Hirudin | heparin | | | Low risk of bias | - | | |
OASIS, 1997 | Hirudin | heparin | | | Risk of bias | - | | |
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TRIM, 1997 | Inogatran | heparin | | | Low risk of bias | - | | |
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FRAXIS (6days), 1998 | nadroparin | UFH (on top of aspirin) | | | Low risk of bias | negative | | |
FRAXIS (14 days), 1998 | nadroparin | UFH (on top of aspirin) | | | Low risk of bias | negative | | |
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SEPIA-ACS1 TIMI 42, 2009 NCT | otamixaban | unfractionated heparin | | | Low risk of bias | suggesting | | |
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TRILOGY ACS (overall population), 2012 NCT | prasugrel | clopidogrel | | | Low risk of bias | negative | | |
TRITON-TIMI 38, 2007 NCT | prasugrel | clopidogrel | | | Low risk of bias | suggesting | | |
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ATLAS ACS 2 - TIMI 51 (2.5mg), 2011 NCT | rivaroxaban 2.5mg | placebo | | | Low risk of bias | suggesting | | |
ATLAS ACS 2 - TIMI 51 (5mg), 2011 NCT | rivaroxaban 5mg | placebo | | | | suggesting | | |
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Canadian (sulfinpyrazone alone), 1985 | sulfinpyrazone | placebo | | | Low risk of bias | - | | |
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PLATO, 2009 NCT | ticagrelor | clopidogrel | | | Low risk of bias | suggesting | | |
DISPERSE-2 (90mg), 2007 | ticagrelor | clopidogrel | | | Low risk of bias | negative | | |
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STAI, 1990 | ticlopidine | control | | | | suggesting | | |
Florida UA | ticlopidine | placebo | | | | negative | | |
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Modena | trapidil | placebo | | | | suggesting | | |
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TIM, 2000 | triflusal | aspirin | | | Low risk of bias | - | | |
Plaza, 1993 | triflusal | placebo | | | Low risk of bias | suggesting | | |
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Holdright, 1994 | UFH | control (on top of aspirin) | | | | negative | | |
RISC (heparin+aspirin vs ASP), 1990 | UFH | control (on top of aspirin) | | | | negative | | |
Theroux (heparin+ASP vs ASP), 1988 | UFH | control (on top of aspirin) | | | Low risk of bias | suggesting | | |
ATACS (Cohen), 1994 | UFH, warfarin | control (on top of aspirin) | | | | negative | | |
Cohen (ATACS pilot) (heparin+aspirin vs asp), 1990 | UFH, warfarin | control (on top of aspirin) | | | | negative | | |
Theroux (heparin vs PBO), 1988 | UFH | placebo | | | Low risk of bias | suggesting | | |
RISC (heparin vs PBO), 1990 | UFH | placebo | | | | negative | | |
Theroux (heparin+aspirin vs PBO), 1988 | UFH + aspirin | placebo | | | Low risk of bias | suggesting | | |
RISC (ASP+ heparin vs PBO), 1990 | UFH + aspirin | placebo | | | | suggesting | | |
Gurfinkel (UFH+aspririn vs aspirin), 1995 | UFH | placebo (on top of aspirin) | | | Low risk of bias | negative | | |
Cohen (ATACS pilot) (heparin vs asp), 1990 | UFH, warfarin | aspirin | | | | negative | | |
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TRACER, 2011 NCT | vorapaxar | placebo (on top standard therapy) | | | Low risk of bias | - | | |
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ATACS (pilot study) (warfarin vs control), 1990 | warfarin | control (on top of aspirin) | | | | negative | | |
ATACS, 1994 | warfarin | control (on top of aspirin) | | | | negative | | |
CARS, 1997 | warfarin | control (on top of aspirin) | | | | negative | | |
OASIS Pilot (phase 1), 1998 | warfarin | control (on top of aspirin) | | | | negative | | |
OASIS Pilot (phase 2), 1998 | warfarin | control (on top of aspirin) | | | | negative | | |
OASIS-2 Warfarin Substudy, 2001 | warfarin | control (on top of aspirin) | | | | negative | | |
APRICOT-2, 2002 | warfarin | control (on top of aspirin) | | | | negative | | |
CHAMP, 2002 | warfarin | control (on top of aspirin) | | | | negative | | |
WARIS, 2002 | warfarin | control (on top of aspirin) | | | | suggesting | | |
LoWASA, 2004 | warfarin | control (on top of aspirin) | | | | negative | | |
Zibaeenezhad, 2004 | warfarin | control (on top of aspirin) | | | | negative | | |
Williams, 1997 | warfarin | placebo (on top of aspirin) | | | Low risk of bias | negative | | |
Huyhn, 2001 | warfarin | placebo (on top of aspirin) | | | Low risk of bias | negative | | |
ATACS (pilot study) warfarin vs aspirin, 1990 | warfarin | aspirin | | | | negative | | |
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ESTEEM, 2003 | ximelagatran | placebo | | | Exploratory | - | | |
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ARGAMI-2, 1998 | Argatroban | heparin | | | | - | | |
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HERO, 1997 | bivalirudin | heparin | | | Low risk of bias | suggesting | | |
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ASPECT-2 (coumadin+ASA vs ASA), 2002 | coumadin | control (on top of aspirin) | | | | negative | | |
ASPECT, 1994 | coumadin | placebo | | | Low risk of bias | suggesting | | |
ASPECT-2 (coumadin alone), 2002 | coumadin | aspirin | | | | suggesting | | |
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FRAMI, 1997 | Dalteparin | placebo | | | | - | | |
BIOMACS II, 1999 | Dalteparin | placebo | | | Low risk of bias | - | | |
ASSENT Plus, 2003 | Dalteparin | UFH | | | | negative | | |
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AMI-SK, 2002 | Enoxaparin | placebo | | | Low risk of bias | - | | |
ASSENT 3, 2001 | Enoxaparin | UFH | | | | suggesting | | |
HART II, 2001 | Enoxaparin | UFH | | | | negative | | |
Baird, 2002 | Enoxaparin | UFH | | | | negative | | |
ENTIRE-TIMI 2, 2002 | Enoxaparin | UFH | | | | suggesting | | |
ASSENT 3 Plus, 2003 | Enoxaparin | UFH | | | | negative | | |
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MICHELANGELO OASIS-6, 2006 NCT | fondaparinux | placebo | | | Low risk of bias | suggesting | | |
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HIT-4, 1999 | Hirudin | heparin | | | Low risk of bias | - | | |
TIMI 9B, 1996 | Hirudin | heparin | | | Risk of bias | - | | |
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CREATE, 2005 | Reviparin | placebo | | | Low risk of bias | - | | |
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ISIS-2 Pilot, 1987 | UFH | no heparin | | | | negative | | |
DUCCS, 1994 | UFH | no heparin | | | | negative | | |
ECSG, 1992 | UFH | placebo | | | Low risk of bias | negative | | |
OSIRIS, 1992 | UFH | placebo | | | Low risk of bias | negative | | |
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APRICOT-2, 2002 | warfarin | control (on top of aspirin) | | | | suggesting | | |
Zibaeenezhad, 2004 | warfarin | control (on top of aspirin) | | | | negative | | |
WARIS, 1999 | warfarin | control (on top of aspirin) | | | Low risk of bias | - | | |
CHAMP, 2002 | warfarin | control (on top of aspirin) | | | | negative |